Sugi Variant

Sugi Variant/FLNB

FLNB — 2800 ClinVar variants

All ClinVar germline FLNB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 1333 flagged for review →

78 Pathogenic · 6 Pathogenic/Likely pathogenic · 69 Likely pathogenic · 262 Conflicting · 166 Benign · 67 Benign/Likely benign · 959 Likely benign · 1193 Uncertain significance

Full FLNB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 1333

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 102

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 598

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 598

Predictors split 632

The independent predictors disagree with each other — read with care. · showing the 150 best-reviewed of 632

All FLNB variants

Pathogenic 78

Pathogenic/Likely pathogenic 6

Likely pathogenic 69

Conflicting classifications of pathogenicity 262

Benign 166

Benign/Likely benign 67

Likely benign 959

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 1193

Showing the top 300 by review status; the full set is in the sitemap.