Sugi Variant

Sugi Variant/FLRT3

FLRT3 — 121 ClinVar variants

All ClinVar germline FLRT3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 82 flagged for review →

1 Pathogenic · 1 Conflicting · 5 Benign · 5 Benign/Likely benign · 22 Likely benign · 87 Uncertain significance

Full FLRT3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 82

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 64

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 16

The independent predictors disagree with each other — read with care.

All FLRT3 variants

Pathogenic 1

  • p.Lys339Arg No assertion criteria hypogonadotropic hypogonadism 21 with or without anosmia ⚠

Conflicting classifications of pathogenicity 1

Benign 5

Benign/Likely benign 5

Likely benign 22

Uncertain significance 87