FLT1 — 155 ClinVar variants
All ClinVar germline FLT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 118 flagged for review →
10 Benign · 20 Likely benign · 125 Uncertain significance
Full FLT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 118
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 79
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FLT1 p.Ala1188Asp Uncertain significance Single submitter
- FLT1 p.Ala1200Val Uncertain significance Single submitter
- FLT1 p.Ala1267Gly Uncertain significance Single submitter
- FLT1 p.Ala1312Thr Uncertain significance Single submitter
- FLT1 p.Ala1319Val Uncertain significance Single submitter
- FLT1 p.Ala381Pro Uncertain significance Single submitter
- FLT1 p.Ala434Thr Uncertain significance Single submitter
- FLT1 p.Ala494Thr Uncertain significance Single submitter
- FLT1 p.Ala610Ser Uncertain significance Single submitter
- FLT1 p.Arg1257His Uncertain significance Single submitter
- FLT1 p.Arg244Thr Uncertain significance Single submitter
- FLT1 p.Arg501Lys Uncertain significance Single submitter
- FLT1 p.Arg639Thr Uncertain significance Single submitter
- FLT1 p.Asn1050Lys Uncertain significance Single submitter
- FLT1 p.Asn1173Ser Uncertain significance Single submitter
- FLT1 p.Asn1328Lys Uncertain significance Single submitter
- FLT1 p.Asn685Ser Uncertain significance Single submitter
- FLT1 p.Asn931Lys Uncertain significance Single submitter
- FLT1 p.Asp1058Tyr Uncertain significance Single submitter
- FLT1 p.Asp1108Glu Uncertain significance Single submitter
- FLT1 p.Asp1165Asn Uncertain significance Single submitter
- FLT1 p.Asp495Gly Uncertain significance Single submitter
- FLT1 p.Asp572Glu Uncertain significance Single submitter
- FLT1 p.Asp933Asn Uncertain significance Single submitter
- FLT1 p.Asp987Glu Uncertain significance Single submitter
- FLT1 p.Gln341Arg Uncertain significance Single submitter
- FLT1 p.Glu153Lys Uncertain significance Single submitter
- FLT1 p.Glu689Lys Uncertain significance Single submitter
- FLT1 p.Glu70Gly Uncertain significance Single submitter
- FLT1 p.Glu943Val Uncertain significance Single submitter
- FLT1 p.Glu946Asp Uncertain significance Single submitter
- FLT1 p.Glu946Lys Uncertain significance Single submitter
- FLT1 p.Gly1096Asp Uncertain significance Single submitter
- FLT1 p.Gly1097Arg Uncertain significance Single submitter
- FLT1 p.Gly1155Asp Uncertain significance Single submitter
- FLT1 p.Gly1303Asp Uncertain significance Single submitter
- FLT1 p.Gly132Asp Uncertain significance Single submitter
- FLT1 p.Gly866Arg Uncertain significance Single submitter
- FLT1 p.Gly988Ser Uncertain significance Single submitter
- FLT1 p.His288Leu Uncertain significance Single submitter
- FLT1 p.His50Arg Uncertain significance Single submitter
- FLT1 p.His683Gln Uncertain significance Single submitter
- FLT1 p.His887Asn Uncertain significance Single submitter
- FLT1 p.Ile165Val Uncertain significance Single submitter
- FLT1 p.Ile229Val Uncertain significance Single submitter
- FLT1 p.Ile405Thr Uncertain significance Single submitter
- FLT1 p.Ile536Val Uncertain significance Single submitter
- FLT1 p.Leu443Val Uncertain significance Single submitter
- FLT1 p.Leu663Phe Uncertain significance Single submitter
- FLT1 p.Leu813Phe Uncertain significance Single submitter
- FLT1 p.Leu827Ile Uncertain significance Single submitter
- FLT1 p.Leu889Val Uncertain significance Single submitter
- FLT1 p.Lys1074Gln Uncertain significance Single submitter
- FLT1 p.Lys1266Glu Uncertain significance Single submitter
- FLT1 p.Lys1280Glu Uncertain significance Single submitter
- FLT1 p.Lys465Arg Uncertain significance Single submitter
- FLT1 p.Lys565Glu Uncertain significance Single submitter
- FLT1 p.Lys608Asn Uncertain significance Single submitter
- FLT1 p.Met1066Thr Uncertain significance Single submitter
- FLT1 p.Met600Ile Uncertain significance Single submitter
- FLT1 p.Met624Thr Uncertain significance Single submitter
- FLT1 p.Met945Thr Uncertain significance Single submitter
- FLT1 p.Pro556Ala Uncertain significance Single submitter
- FLT1 p.Pro688Ala Uncertain significance Single submitter
- FLT1 p.Pro853Ser Uncertain significance Single submitter
- FLT1 p.Pro940Thr Uncertain significance Single submitter
- FLT1 p.Ser1014Phe Uncertain significance Single submitter
- FLT1 p.Ser356Thr Uncertain significance Single submitter
- FLT1 p.Ser364Leu Uncertain significance Single submitter
- FLT1 p.Ser870Arg Uncertain significance Single submitter
- FLT1 p.Thr222Ile Uncertain significance Single submitter
- FLT1 p.Thr421Ser Uncertain significance Single submitter
- FLT1 p.Thr654Ser Uncertain significance Single submitter
- FLT1 p.Thr761Ala Uncertain significance Single submitter
- FLT1 p.Tyr1309Cys Uncertain significance Single submitter
- FLT1 p.Val1103Leu Uncertain significance Single submitter
- FLT1 p.Val1331Ile Uncertain significance Single submitter
- FLT1 p.Val211Ile Uncertain significance Single submitter
- FLT1 p.Val2Ile Uncertain significance Single submitter
Predictors split 39
The independent predictors disagree with each other — read with care.
- FLT1 p.Ile548Met Likely benign Multiple submitters
- FLT1 p.Ala80Asp Uncertain significance Single submitter
- FLT1 p.Arg159Gln Uncertain significance Single submitter
- FLT1 p.Arg183Cys Uncertain significance Single submitter
- FLT1 p.Arg354Trp Uncertain significance Single submitter
- FLT1 p.Arg386His Likely benign Single submitter
- FLT1 p.Arg508Cys Uncertain significance Single submitter
- FLT1 p.Arg528Gly Uncertain significance Single submitter
- FLT1 p.Asn196Lys Uncertain significance Single submitter
- FLT1 p.Asn323Lys Uncertain significance Single submitter
- FLT1 p.Asp1140His Uncertain significance Single submitter
- FLT1 p.Cys471Tyr Uncertain significance Single submitter
- FLT1 p.Glu1032Asp Uncertain significance Single submitter
- FLT1 p.Glu1123Gly Uncertain significance Single submitter
- FLT1 p.Glu1143Ala Uncertain significance Single submitter
- FLT1 p.Glu121Asp Uncertain significance Single submitter
- FLT1 p.Glu345Gly Uncertain significance Single submitter
- FLT1 p.Gly632Ser Uncertain significance Single submitter
- FLT1 p.Ile1019Val Uncertain significance Single submitter
- FLT1 p.Ile1028Val Uncertain significance Single submitter
- FLT1 p.Ile502Thr Uncertain significance Single submitter
- FLT1 p.Ile505Thr Uncertain significance Single submitter
- FLT1 p.Ile718Phe Uncertain significance Single submitter
- FLT1 p.Leu1157Phe Uncertain significance Single submitter
- FLT1 p.Leu1269Phe Uncertain significance Single submitter
- FLT1 p.Leu248Phe Uncertain significance Single submitter
- FLT1 p.Leu51Phe Uncertain significance Single submitter
- FLT1 p.Leu813Ile Uncertain significance Single submitter
- FLT1 p.Lys873Glu Uncertain significance Single submitter
- FLT1 p.Phe88Leu Uncertain significance Single submitter
- FLT1 p.Pro237Thr Uncertain significance Single submitter
- FLT1 p.Pro365Leu Uncertain significance Single submitter
- FLT1 p.Pro814Ser Uncertain significance Single submitter
- FLT1 p.Ser1252Tyr Uncertain significance Single submitter
- FLT1 p.Ser90Asn Uncertain significance Single submitter
- FLT1 p.Thr1078Ala Uncertain significance Single submitter
- FLT1 p.Thr1126Ala Uncertain significance Single submitter
- FLT1 p.Thr506Ala Uncertain significance Single submitter
- FLT1 p.Thr594Ile Uncertain significance Single submitter
All FLT1 variants
Benign 10
- p.Asp6Asn Multiple submitters
- p.Leu492= Multiple submitters
- p.Pro1068= Multiple submitters colon carcinoma
- p.Thr260= Multiple submitters
- p.Val687= Multiple submitters
- c.3175-10C>T Single submitter
- c.3815+159A>G Single submitter squamous cell carcinoma
- p.Ala434= Single submitter
- p.Phe135= Single submitter
- p.Tyr794= Single submitter
Likely benign 20
- p.Cys107= Multiple submitters
- p.Ile548Met Multiple submitters ⚠
- p.Met938Val Multiple submitters
- p.Pro1201Leu Multiple submitters
- p.Tyr1184= Multiple submitters
- c.2117-10929ATC[4] Single submitter
- p.Arg280Gln Single submitter
- p.Arg386His Single submitter ⚠
- p.Arg54= Single submitter
- p.Cys1018= Single submitter
- p.Ile291Val Single submitter
- p.Ile552Val Single submitter
- p.Pro1323= Single submitter
- p.Pro428= Single submitter
- p.Pro567= Single submitter
- p.Ser285Arg Single submitter
- p.Thr1186= Single submitter
- p.Val249Ile Single submitter
- p.Val587Ile Single submitter
- p.Arg54Ser No assertion criteria FLT1-related disorder
Uncertain significance 125
- c.1106+219G>T Single submitter lung adenocarcinoma
- c.2594-52G>A Single submitter lung adenocarcinoma
- c.2708-190C>T Single submitter lung adenocarcinoma
- c.2708-195G>T Single submitter lung adenocarcinoma
- c.3174+225T>G Single submitter lung adenocarcinoma
- c.3721-78C>A Single submitter lung adenocarcinoma
- c.513+216C>T Single submitter squamous cell carcinoma
- c.64+22G>T Single submitter squamous cell carcinoma
- p.Ala1188Asp Single submitter ⚠
- p.Ala1200Val Single submitter ⚠
- p.Ala1267Gly Single submitter ⚠
- p.Ala1312Thr Single submitter ⚠
- p.Ala1319Val Single submitter ⚠
- p.Ala381Pro Single submitter ⚠
- p.Ala434Thr Single submitter ⚠
- p.Ala494Thr Single submitter ⚠
- p.Ala610Ser Single submitter ⚠
- p.Ala80Asp Single submitter ⚠
- p.Arg1257His Single submitter ⚠
- p.Arg159Gln Single submitter ⚠
- p.Arg183Cys Single submitter ⚠
- p.Arg244Thr Single submitter ⚠
- p.Arg354Trp Single submitter ⚠
- p.Arg501Lys Single submitter ⚠
- p.Arg508Cys Single submitter ⚠
- p.Arg528Gly Single submitter ⚠
- p.Arg639Thr Single submitter ⚠
- p.Asn1050Lys Single submitter ⚠
- p.Asn1173Ser Single submitter ⚠
- p.Asn1328Lys Single submitter ⚠
- p.Asn196Lys Single submitter ⚠
- p.Asn323Lys Single submitter ⚠
- p.Asn685Ser Single submitter ⚠
- p.Asn931Lys Single submitter ⚠
- p.Asp1058Tyr Single submitter ⚠
- p.Asp1108Glu Single submitter ⚠
- p.Asp1140His Single submitter ⚠
- p.Asp1165Asn Single submitter ⚠
- p.Asp495Gly Single submitter ⚠
- p.Asp572Glu Single submitter ⚠
- p.Asp933Asn Single submitter ⚠
- p.Asp987Glu Single submitter ⚠
- p.Cys471Tyr Single submitter ⚠
- p.Gln341Arg Single submitter ⚠
- p.Glu1032Asp Single submitter ⚠
- p.Glu1123Gly Single submitter ⚠
- p.Glu1143Ala Single submitter ⚠
- p.Glu121Asp Single submitter ⚠
- p.Glu153Lys Single submitter ⚠
- p.Glu345Gly Single submitter ⚠
- p.Glu689Lys Single submitter ⚠
- p.Glu70Gly Single submitter ⚠
- p.Glu943Val Single submitter ⚠
- p.Glu946Asp Single submitter ⚠
- p.Glu946Lys Single submitter ⚠
- p.Gly1096Asp Single submitter ⚠
- p.Gly1097Arg Single submitter ⚠
- p.Gly1155Asp Single submitter ⚠
- p.Gly1303Asp Single submitter ⚠
- p.Gly132Asp Single submitter ⚠
- p.Gly632Ser Single submitter ⚠
- p.Gly866Arg Single submitter ⚠
- p.Gly988Ser Single submitter ⚠
- p.His288Leu Single submitter ⚠
- p.His50Arg Single submitter ⚠
- p.His683Gln Single submitter ⚠
- p.His887Asn Single submitter ⚠
- p.Ile1019Val Single submitter ⚠
- p.Ile1028Val Single submitter ⚠
- p.Ile165Val Single submitter ⚠
- p.Ile229Val Single submitter ⚠
- p.Ile405Thr Single submitter ⚠
- p.Ile502Thr Single submitter ⚠
- p.Ile505Thr Single submitter ⚠
- p.Ile536Val Single submitter ⚠
- p.Ile718Phe Single submitter ⚠
- p.Leu1157Phe Single submitter ⚠
- p.Leu1269Phe Single submitter ⚠
- p.Leu248Phe Single submitter ⚠
- p.Leu443Val Single submitter ⚠
- p.Leu51Phe Single submitter ⚠
- p.Leu663Phe Single submitter ⚠
- p.Leu813Ile Single submitter ⚠
- p.Leu813Phe Single submitter ⚠
- p.Leu827Ile Single submitter ⚠
- p.Leu889Val Single submitter ⚠
- p.Lys1074Gln Single submitter ⚠
- p.Lys1266Glu Single submitter ⚠
- p.Lys1280Glu Single submitter ⚠
- p.Lys465Arg Single submitter ⚠
- p.Lys565Glu Single submitter ⚠
- p.Lys608Asn Single submitter ⚠
- p.Lys873Glu Single submitter ⚠
- p.Met1066Thr Single submitter ⚠
- p.Met600Ile Single submitter ⚠
- p.Met624Thr Single submitter ⚠
- p.Met945Thr Single submitter ⚠
- p.Phe88Leu Single submitter ⚠
- p.Pro237Thr Single submitter ⚠
- p.Pro365Leu Single submitter ⚠
- p.Pro556Ala Single submitter ⚠
- p.Pro688Ala Single submitter ⚠
- p.Pro814Ser Single submitter ⚠
- p.Pro853Ser Single submitter ⚠
- p.Pro940Thr Single submitter ⚠
- p.Ser1014Phe Single submitter ⚠
- p.Ser1252Tyr Single submitter ⚠
- p.Ser356Thr Single submitter ⚠
- p.Ser364Leu Single submitter ⚠
- p.Ser870Arg Single submitter ⚠
- p.Ser90Asn Single submitter ⚠
- p.Thr1078Ala Single submitter ⚠
- p.Thr1126Ala Single submitter ⚠
- p.Thr222Ile Single submitter ⚠
- p.Thr421Ser Single submitter ⚠
- p.Thr506Ala Single submitter ⚠
- p.Thr594Ile Single submitter ⚠
- p.Thr654Ser Single submitter ⚠
- p.Thr761Ala Single submitter ⚠
- p.Tyr1309Cys Single submitter ⚠
- p.Val1103Leu Single submitter ⚠
- p.Val1331Ile Single submitter ⚠
- p.Val211Ile Single submitter ⚠
- p.Val2Ile Single submitter ⚠
- p.Tyr815fs No assertion criteria colon carcinoma