FMNL1 — 163 ClinVar variants

All ClinVar germline FMNL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 151 flagged for review →

1 Benign · 5 Likely benign · 157 Uncertain significance

Full FMNL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 151

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 106

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 45

The independent predictors disagree with each other — read with care.

All FMNL1 variants

Benign 1

c.895-3C>T Multiple submitters

Likely benign 5

p.Ala738= Single submitter
p.Gly984Ser Single submitter
p.Phe640= Single submitter
p.Pro1021Leu Single submitter
p.Pro18Ser Single submitter

Uncertain significance 157

c.1885+2T>A Single submitter
p.Ala1012Thr Single submitter ⚠
p.Ala157Gly Single submitter
p.Ala16Val Single submitter ⚠
p.Ala31Glu Single submitter ⚠
p.Ala386Val Single submitter ⚠
p.Ala409Val Single submitter ⚠
p.Ala516Thr Single submitter ⚠
p.Ala557Val Single submitter ⚠
p.Ala632Thr Single submitter ⚠
p.Ala703Pro Single submitter ⚠
p.Ala743Val Single submitter ⚠
p.Ala917Val Single submitter ⚠
p.Arg1036Trp Single submitter ⚠
p.Arg1080Pro Single submitter ⚠
p.Arg1087Gln Single submitter ⚠
p.Arg1087Trp Single submitter ⚠
p.Arg122Trp Single submitter ⚠
p.Arg145Cys Single submitter ⚠
p.Arg200Cys Single submitter ⚠
p.Arg200His Single submitter ⚠
p.Arg235His Single submitter ⚠
p.Arg283Trp Single submitter ⚠
p.Arg314Trp Single submitter ⚠
p.Arg416Trp Single submitter ⚠
p.Arg723Trp Single submitter ⚠
p.Arg762Cys Single submitter ⚠
p.Arg767Cys Single submitter ⚠
p.Arg767His Single submitter ⚠
p.Arg770Trp Single submitter ⚠
p.Arg773Gln Single submitter ⚠
p.Arg773Trp Single submitter ⚠
p.Arg783His Single submitter ⚠
p.Arg783Leu Single submitter ⚠
p.Arg790His Single submitter ⚠
p.Arg797Cys Single submitter ⚠
p.Arg797His Single submitter ⚠
p.Arg835Cys Single submitter ⚠
p.Arg835His Single submitter ⚠
p.Arg875His Single submitter ⚠
p.Arg935Trp Single submitter ⚠
p.Arg992His Single submitter ⚠
p.Asn107Lys Single submitter ⚠
p.Asn107Thr Single submitter ⚠
p.Asn141Ser Single submitter ⚠
p.Asn178Ile Single submitter ⚠
p.Asn420Lys Single submitter ⚠
p.Asn61Ser Single submitter ⚠
p.Asp169Asn Single submitter ⚠
p.Asp169Gly Single submitter ⚠
p.Asp356Gly Single submitter ⚠
p.Asp497Tyr Single submitter ⚠
p.Asp529Val Single submitter ⚠
p.Asp583His Single submitter ⚠
p.Asp913Asn Single submitter ⚠
p.Gln1006Pro Single submitter ⚠
p.Gln1014His Single submitter ⚠
p.Gln21His Single submitter ⚠
p.Gln21Pro Single submitter ⚠
p.Gln223Arg Single submitter ⚠
p.Gln303Pro Single submitter ⚠
p.Gln680Arg Single submitter ⚠
p.Gln817Glu Single submitter ⚠
p.Glu1025Gln Single submitter ⚠
p.Glu349Ala Single submitter ⚠
p.Glu62Lys Single submitter ⚠
p.Glu730Lys Single submitter ⚠
p.Glu839Ter Single submitter
p.Glu927Gln Single submitter ⚠
p.Gly1063Arg Single submitter ⚠
p.Gly109Val Single submitter ⚠
p.Gly301Ala Single submitter ⚠
p.Gly496Val Single submitter ⚠
p.Gly513Asp Single submitter ⚠
p.Gly550Cys Single submitter ⚠
p.Gly582Glu Single submitter ⚠
p.Gly596Val Single submitter ⚠
p.Gly599Arg Single submitter ⚠
p.Gly620Arg Single submitter ⚠
p.His286Tyr Single submitter ⚠
p.Ile237Val Single submitter ⚠
p.Ile426Thr Single submitter ⚠
p.Ile828Ser Single submitter ⚠
p.Ile994Phe Single submitter ⚠
p.Leu1094Arg Single submitter ⚠
p.Leu121Val Single submitter ⚠
p.Leu378Gln Single submitter ⚠
p.Leu692Phe Single submitter ⚠
p.Leu764Phe Single submitter ⚠
p.Lys198Arg Single submitter ⚠
p.Lys20Arg Single submitter ⚠
p.Lys682Arg Single submitter ⚠
p.Lys706Arg Single submitter ⚠
p.Lys876Glu Single submitter
p.Lys890Asn Single submitter ⚠
p.Lys943Arg Single submitter ⚠
p.Lys961Met Single submitter ⚠
p.Lys979Arg Single submitter ⚠
p.Met105Ile Single submitter
p.Met423Val Single submitter ⚠
p.Met453Thr Single submitter ⚠
p.Met674Leu Single submitter ⚠
p.Met775Val Single submitter ⚠
p.Met826Ile Single submitter ⚠
p.Met848Ile Single submitter ⚠
p.Met953Val Single submitter ⚠
p.Phe322Tyr Single submitter
p.Phe788Leu Single submitter ⚠
p.Phe933Leu Single submitter ⚠
p.Pro1026Ser Single submitter ⚠
p.Pro1033Leu Single submitter ⚠
p.Pro1033Ser Single submitter ⚠
p.Pro197Ser Single submitter ⚠
p.Pro28Leu Single submitter ⚠
p.Pro460Ala Single submitter ⚠
p.Pro519Leu Single submitter ⚠
p.Pro526Ser Single submitter ⚠
p.Pro547Gln Single submitter ⚠
p.Pro552Leu Single submitter ⚠
p.Pro554Ser Single submitter ⚠
p.Pro567Leu Single submitter ⚠
p.Pro575Arg Single submitter ⚠
p.Pro578Leu Single submitter ⚠
p.Pro585Leu Single submitter ⚠
p.Pro589Leu Single submitter ⚠
p.Pro590Ser Single submitter ⚠
p.Pro593Leu Single submitter ⚠
p.Pro595Leu Single submitter ⚠
p.Pro602Leu Single submitter ⚠
p.Pro602Ser Single submitter ⚠
p.Pro612Leu Single submitter ⚠
p.Pro615Arg Single submitter ⚠
p.Pro792Leu Single submitter ⚠
p.Pro795Leu Single submitter ⚠
p.Pro808Leu Single submitter ⚠
p.Pro978Ala Single submitter ⚠
p.Pro978Leu Single submitter ⚠
p.Pro978Thr Single submitter ⚠
p.Ser117Thr Single submitter ⚠
p.Ser260Gly Single submitter ⚠
p.Ser448Asn Single submitter ⚠
p.Ser512Gly Single submitter ⚠
p.Ser685Phe Single submitter ⚠
p.Ser689Gly Single submitter ⚠
p.Ser693Arg Single submitter ⚠
p.Ser988Phe Single submitter ⚠
p.Thr1078Arg Single submitter ⚠
p.Thr168Ile Single submitter ⚠
p.Thr351Ala Single submitter ⚠
p.Thr523Ile Single submitter ⚠
p.Thr523Pro Single submitter ⚠
p.Thr952Ile Single submitter ⚠
p.Tyr739Cys Single submitter ⚠
p.Val221Ile Single submitter ⚠
p.Val337Met Single submitter ⚠
p.Val499Leu Single submitter ⚠
p.Val601Leu Single submitter ⚠