Sugi Variant

Sugi Variant/FMO3

FMO3 — 300 ClinVar variants

All ClinVar germline FMO3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 87 flagged for review →

33 Pathogenic · 18 Pathogenic/Likely pathogenic · 39 Likely pathogenic · 26 Conflicting · 7 Benign · 13 Benign/Likely benign · 91 Likely benign · 73 Uncertain significance

Full FMO3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 87

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 3

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 11

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 50

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 23

The independent predictors disagree with each other — read with care.

All FMO3 variants

Pathogenic 33

Pathogenic/Likely pathogenic 18

Likely pathogenic 39

Conflicting classifications of pathogenicity 26

Benign 7

Benign/Likely benign 13

Likely benign 91

Uncertain significance 73