FMO4 — 80 ClinVar variants
All ClinVar germline FMO4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
3 Benign · 4 Likely benign · 73 Uncertain significance
Full FMO4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 54
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FMO4 p.Ala159Asp Uncertain significance Single submitter
- FMO4 p.Arg116Ser Uncertain significance Single submitter
- FMO4 p.Arg205Gln Uncertain significance Single submitter
- FMO4 p.Arg237Thr Uncertain significance Single submitter
- FMO4 p.Arg492Gly Uncertain significance Single submitter
- FMO4 p.Asn359Tyr Uncertain significance Single submitter
- FMO4 p.Asp23Glu Uncertain significance Single submitter
- FMO4 p.Asp285Asn Uncertain significance Single submitter
- FMO4 p.Cys111Trp Uncertain significance Single submitter
- FMO4 p.Cys21Arg Uncertain significance Single submitter
- FMO4 p.Cys345Tyr Uncertain significance Single submitter
- FMO4 p.Gln135Arg Uncertain significance Single submitter
- FMO4 p.Gln245Arg Uncertain significance Single submitter
- FMO4 p.Glu24Asp Uncertain significance Single submitter
- FMO4 p.Glu27Lys Uncertain significance Single submitter
- FMO4 p.Glu304Gln Uncertain significance Single submitter
- FMO4 p.Glu319Lys Uncertain significance Single submitter
- FMO4 p.Glu460Ala Uncertain significance Single submitter
- FMO4 p.Glu76Lys Uncertain significance Single submitter
- FMO4 p.Gly222Ala Uncertain significance Single submitter
- FMO4 p.Gly228Ser Uncertain significance Single submitter
- FMO4 p.Gly369Arg Uncertain significance Single submitter
- FMO4 p.Gly380Ser Uncertain significance Single submitter
- FMO4 p.Gly38Arg Uncertain significance Single submitter
- FMO4 p.His154Tyr Uncertain significance Single submitter
- FMO4 p.His513Arg Uncertain significance Single submitter
- FMO4 p.His84Arg Uncertain significance Single submitter
- FMO4 p.Ile296Asn Uncertain significance Single submitter
- FMO4 p.Leu473Phe Uncertain significance Single submitter
- FMO4 p.Lys280Ile Uncertain significance Single submitter
- FMO4 p.Lys347Glu Uncertain significance Single submitter
- FMO4 p.Met298Val Uncertain significance Single submitter
- FMO4 p.Met434Thr Uncertain significance Single submitter
- FMO4 p.Met82Leu Uncertain significance Single submitter
- FMO4 p.Phe281Leu Uncertain significance Single submitter
- FMO4 p.Phe350Leu Uncertain significance Single submitter
- FMO4 p.Phe392Cys Uncertain significance Single submitter
- FMO4 p.Phe451Ser Uncertain significance Single submitter
- FMO4 p.Phe463Ser Uncertain significance Single submitter
-
FMO4 p.Pro28His
Uncertain significance
Single submitter
trimethylaminuria
- FMO4 p.Ser225Leu Uncertain significance Single submitter
- FMO4 p.Ser301Arg Uncertain significance Single submitter
- FMO4 p.Thr114Met Uncertain significance Single submitter
- FMO4 p.Thr131Lys Uncertain significance Single submitter
- FMO4 p.Thr274Ser Uncertain significance Single submitter
- FMO4 p.Thr493Ala Uncertain significance Single submitter
- FMO4 p.Thr493Ile Uncertain significance Single submitter
- FMO4 p.Val235Phe Uncertain significance Single submitter
- FMO4 p.Val317Ala Uncertain significance Single submitter
- FMO4 p.Val323Ile Uncertain significance Single submitter
- FMO4 p.Val522Leu Uncertain significance Single submitter
- FMO4 p.Val54Ile Uncertain significance Single submitter
- FMO4 p.Val553Gly Uncertain significance Single submitter
- FMO4 p.Val62Ile Uncertain significance Single submitter
Predictors split 15
The independent predictors disagree with each other — read with care.
- FMO4 p.Arg186Cys Uncertain significance Single submitter
- FMO4 p.Arg456Gly Uncertain significance Single submitter
- FMO4 p.Asp118Gly Uncertain significance Single submitter
- FMO4 p.Cys63Phe Uncertain significance Single submitter
- FMO4 p.Gln105Leu Uncertain significance Single submitter
- FMO4 p.Glu318Lys Uncertain significance Single submitter
- FMO4 p.Gly133Ser Uncertain significance Single submitter
- FMO4 p.His84Leu Uncertain significance Single submitter
- FMO4 p.Lys115Thr Uncertain significance Single submitter
- FMO4 p.Pro179Leu Uncertain significance Single submitter
- FMO4 p.Thr122Ile Uncertain significance Single submitter
- FMO4 p.Thr488Asn Uncertain significance Single submitter
- FMO4 p.Trp490Arg Uncertain significance Single submitter
- FMO4 p.Tyr433Cys Uncertain significance Single submitter
- FMO4 p.Val187Ile Likely benign Single submitter
All FMO4 variants
Benign 3
- p.Ser534Pro Multiple submitters
- p.Gln402= Single submitter
- p.Phe281= Single submitter
Likely benign 4
- p.Gly372Ser Multiple submitters
- p.Leu221His Multiple submitters
- p.Lys421Gln Single submitter
- p.Val187Ile Single submitter ⚠
Uncertain significance 73
- c.1180+3A>G Multiple submitters
- p.Ala159Asp Single submitter ⚠
- p.Arg116Ser Single submitter ⚠
- p.Arg186Cys Single submitter ⚠
- p.Arg205Gln Single submitter ⚠
- p.Arg237Thr Single submitter ⚠
- p.Arg456Gly Single submitter ⚠
- p.Arg492Gly Single submitter ⚠
- p.Asn359Tyr Single submitter ⚠
- p.Asp118Gly Single submitter ⚠
- p.Asp23Glu Single submitter ⚠
- p.Asp285Asn Single submitter ⚠
- p.Asp322Glu Single submitter
- p.Cys111Trp Single submitter ⚠
- p.Cys21Arg Single submitter ⚠
- p.Cys345Tyr Single submitter ⚠
- p.Cys63Phe Single submitter ⚠
- p.Gln105Leu Single submitter ⚠
- p.Gln135Arg Single submitter ⚠
- p.Gln245Arg Single submitter ⚠
- p.Glu24Asp Single submitter ⚠
- p.Glu27Lys Single submitter ⚠
- p.Glu304Gln Single submitter ⚠
- p.Glu318Lys Single submitter ⚠
- p.Glu319Lys Single submitter ⚠
- p.Glu460Ala Single submitter ⚠
- p.Glu76Lys Single submitter ⚠
- p.Gly133Ser Single submitter ⚠
- p.Gly222Ala Single submitter ⚠
- p.Gly228Ser Single submitter ⚠
- p.Gly369Arg Single submitter ⚠
- p.Gly380Ser Single submitter ⚠
- p.Gly38Arg Single submitter ⚠
- p.His154Tyr Single submitter ⚠
- p.His513Arg Single submitter ⚠
- p.His84Arg Single submitter ⚠
- p.His84Leu Single submitter ⚠
- p.Ile296Asn Single submitter ⚠
- p.Leu473Phe Single submitter ⚠
- p.Lys115Thr Single submitter ⚠
- p.Lys280Ile Single submitter ⚠
- p.Lys347Glu Single submitter ⚠
- p.Met298Val Single submitter ⚠
- p.Met434Thr Single submitter ⚠
- p.Met82Leu Single submitter ⚠
- p.Phe281Leu Single submitter ⚠
- p.Phe350Leu Single submitter ⚠
- p.Phe392Cys Single submitter ⚠
- p.Phe451Ser Single submitter ⚠
- p.Phe463Ser Single submitter ⚠
- p.Pro179Leu Single submitter ⚠
- p.Pro28His Single submitter trimethylaminuria ⚠
- p.Ser225Leu Single submitter ⚠
- p.Ser301Arg Single submitter ⚠
- p.Ser34Ile Single submitter
- p.Thr108Ile Single submitter
- p.Thr114Met Single submitter ⚠
- p.Thr122Ile Single submitter ⚠
- p.Thr131Lys Single submitter ⚠
- p.Thr274Ser Single submitter ⚠
- p.Thr29Pro Single submitter
- p.Thr488Asn Single submitter ⚠
- p.Thr493Ala Single submitter ⚠
- p.Thr493Ile Single submitter ⚠
- p.Trp490Arg Single submitter ⚠
- p.Tyr433Cys Single submitter ⚠
- p.Val235Phe Single submitter ⚠
- p.Val317Ala Single submitter ⚠
- p.Val323Ile Single submitter ⚠
- p.Val522Leu Single submitter ⚠
- p.Val54Ile Single submitter ⚠
- p.Val553Gly Single submitter ⚠
- p.Val62Ile Single submitter ⚠