FN3K — 59 ClinVar variants
All ClinVar germline FN3K variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 56 flagged for review →
1 Likely benign · 58 Uncertain significance
Full FN3K gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 56
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FN3K p.Ala169Val Uncertain significance Single submitter
- FN3K p.Ala175Val Uncertain significance Single submitter
- FN3K p.Ala224Ser Uncertain significance Single submitter
- FN3K p.Arg170Gln Uncertain significance Single submitter
- FN3K p.Arg190Gly Uncertain significance Single submitter
- FN3K p.Arg195Gly Uncertain significance Single submitter
- FN3K p.Arg257Lys Uncertain significance Single submitter
- FN3K p.Arg265Gln Uncertain significance Single submitter
- FN3K p.Arg276Gly Uncertain significance Single submitter
- FN3K p.Arg63Lys Uncertain significance Single submitter
- FN3K p.Arg72Lys Uncertain significance Single submitter
- FN3K p.Asn287Tyr Uncertain significance Single submitter
- FN3K p.Gln106Pro Uncertain significance Single submitter
- FN3K p.Gln275Glu Uncertain significance Single submitter
- FN3K p.Gln3Glu Uncertain significance Single submitter
- FN3K p.Glu243Lys Uncertain significance Single submitter
- FN3K p.Gly134Cys Uncertain significance Single submitter
- FN3K p.Gly144Cys Uncertain significance Single submitter
- FN3K p.Gly144Ser Uncertain significance Single submitter
- FN3K p.Gly152Ser Uncertain significance Single submitter
- FN3K p.Gly302Ala Uncertain significance Single submitter
- FN3K p.His241Arg Uncertain significance Single submitter
- FN3K p.Leu214Phe Uncertain significance Single submitter
- FN3K p.Lys102Gln Uncertain significance Single submitter
- FN3K p.Lys120Glu Uncertain significance Single submitter
- FN3K p.Met107Ile Uncertain significance Single submitter
- FN3K p.Phe143Ile Uncertain significance Single submitter
- FN3K p.Phe145Leu Uncertain significance Single submitter
- FN3K p.Phe17Val Uncertain significance Single submitter
- FN3K p.Pro165Thr Uncertain significance Single submitter
- FN3K p.Pro235Ser Uncertain significance Single submitter
- FN3K p.Pro80Gln Uncertain significance Single submitter
- FN3K p.Ser220Ala Uncertain significance Single submitter
- FN3K p.Thr11Ser Uncertain significance Single submitter
- FN3K p.Thr13Ile Uncertain significance Single submitter
- FN3K p.Thr147Met Uncertain significance Single submitter
- FN3K p.Thr166Ser Uncertain significance Single submitter
- FN3K p.Tyr263Cys Uncertain significance Single submitter
Predictors split 18
The independent predictors disagree with each other — read with care.
- FN3K p.Ala175Glu Uncertain significance Single submitter
- FN3K p.Ala85Thr Uncertain significance Single submitter
- FN3K p.Arg170Trp Uncertain significance Single submitter
- FN3K p.Arg69Gln Uncertain significance Single submitter
- FN3K p.Glu8Lys Uncertain significance Single submitter
- FN3K p.Gly254Ala Uncertain significance Single submitter
- FN3K p.Gly82Asp Uncertain significance Single submitter
- FN3K p.His264Gln Uncertain significance Single submitter
- FN3K p.Leu277Pro Uncertain significance Single submitter
- FN3K p.Lys269Asn Uncertain significance Single submitter
- FN3K p.Phe283Leu Uncertain significance Single submitter
- FN3K p.Pro155Leu Uncertain significance Single submitter
- FN3K p.Pro201Leu Uncertain significance Single submitter
- FN3K p.Pro271Leu Uncertain significance Single submitter
- FN3K p.Pro80Leu Uncertain significance Single submitter
- FN3K p.Ser300Tyr Uncertain significance Single submitter
- FN3K p.Thr65Met Uncertain significance Single submitter
- FN3K p.Tyr285Ser Uncertain significance Single submitter
All FN3K variants
Likely benign 1
- p.Ala169Thr Single submitter
Uncertain significance 58
- p.Ala169Val Single submitter ⚠
- p.Ala175Glu Single submitter ⚠
- p.Ala175Val Single submitter ⚠
- p.Ala224Ser Single submitter ⚠
- p.Ala85Thr Single submitter ⚠
- p.Arg170Gln Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg190Gly Single submitter ⚠
- p.Arg195Gly Single submitter ⚠
- p.Arg257Lys Single submitter ⚠
- p.Arg265Gln Single submitter ⚠
- p.Arg276Gly Single submitter ⚠
- p.Arg63Lys Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Arg72Lys Single submitter ⚠
- p.Asn287Tyr Single submitter ⚠
- p.Gln106Pro Single submitter ⚠
- p.Gln275Glu Single submitter ⚠
- p.Gln3Glu Single submitter ⚠
- p.Glu243Lys Single submitter ⚠
- p.Glu8Lys Single submitter ⚠
- p.Gly134Cys Single submitter ⚠
- p.Gly144Cys Single submitter ⚠
- p.Gly144Ser Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly254Ala Single submitter ⚠
- p.Gly302Ala Single submitter ⚠
- p.Gly82Asp Single submitter ⚠
- p.His241Arg Single submitter ⚠
- p.His264Gln Single submitter ⚠
- p.Ile267Asn Single submitter
- p.Leu214Phe Single submitter ⚠
- p.Leu277Pro Single submitter ⚠
- p.Leu279Phe Single submitter
- p.Lys102Gln Single submitter ⚠
- p.Lys120Glu Single submitter ⚠
- p.Lys269Asn Single submitter ⚠
- p.Met107Ile Single submitter ⚠
- p.Phe143Ile Single submitter ⚠
- p.Phe145Leu Single submitter ⚠
- p.Phe17Val Single submitter ⚠
- p.Phe283Leu Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro165Thr Single submitter ⚠
- p.Pro201Leu Single submitter ⚠
- p.Pro235Ser Single submitter ⚠
- p.Pro271Leu Single submitter ⚠
- p.Pro80Gln Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser220Ala Single submitter ⚠
- p.Ser300Tyr Single submitter ⚠
- p.Thr11Ser Single submitter ⚠
- p.Thr13Ile Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Thr166Ser Single submitter ⚠
- p.Thr65Met Single submitter ⚠
- p.Tyr263Cys Single submitter ⚠
- p.Tyr285Ser Single submitter ⚠