FN3KRP — 83 ClinVar variants
All ClinVar germline FN3KRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
4 Likely benign · 79 Uncertain significance
Full FN3KRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FN3KRP p.Ala108Pro Uncertain significance Single submitter
- FN3KRP p.Ala108Val Uncertain significance Single submitter
- FN3KRP p.Ala125Thr Uncertain significance Single submitter
- FN3KRP p.Ala262Thr Uncertain significance Single submitter
- FN3KRP p.Arg121Cys Uncertain significance Single submitter
- FN3KRP p.Arg137Gln Uncertain significance Single submitter
- FN3KRP p.Arg137Trp Uncertain significance Single submitter
- FN3KRP p.Arg187Gly Uncertain significance Single submitter
- FN3KRP p.Arg205His Uncertain significance Single submitter
- FN3KRP p.Arg276Cys Uncertain significance Single submitter
- FN3KRP p.Arg276His Uncertain significance Single submitter
- FN3KRP p.Asn158Ser Uncertain significance Single submitter
- FN3KRP p.Asn287Ser Uncertain significance Single submitter
- FN3KRP p.Asn290Thr Uncertain significance Single submitter
- FN3KRP p.Asp113Gly Uncertain significance Single submitter
- FN3KRP p.Gln156Arg Uncertain significance Single submitter
- FN3KRP p.Gln27Glu Uncertain significance Single submitter
- FN3KRP p.Glu119Asp Uncertain significance Single submitter
- FN3KRP p.Glu136Val Uncertain significance Single submitter
- FN3KRP p.Glu55Gly Uncertain significance Single submitter
- FN3KRP p.Glu55Lys Uncertain significance Single submitter
- FN3KRP p.Gly10Arg Uncertain significance Single submitter
- FN3KRP p.Gly131Arg Uncertain significance Single submitter
- FN3KRP p.Gly133Val Uncertain significance Single submitter
- FN3KRP p.Gly22Ser Uncertain significance Single submitter
- FN3KRP p.Gly240Ser Uncertain significance Single submitter
- FN3KRP p.Gly28Val Uncertain significance Single submitter
- FN3KRP p.Gly81Ser Uncertain significance Single submitter
- FN3KRP p.Ile267Val Uncertain significance Single submitter
- FN3KRP p.Ile303Thr Uncertain significance Single submitter
- FN3KRP p.Lys102Gln Uncertain significance Single submitter
- FN3KRP p.Met251Thr Uncertain significance Single submitter
- FN3KRP p.Phe143Leu Uncertain significance Single submitter
- FN3KRP p.Phe255Ser Uncertain significance Single submitter
- FN3KRP p.Pro230Leu Uncertain significance Single submitter
- FN3KRP p.Ser194Pro Uncertain significance Single submitter
- FN3KRP p.Ser237Tyr Uncertain significance Single submitter
- FN3KRP p.Ser26Asn Uncertain significance Single submitter
- FN3KRP p.Ser299Thr Uncertain significance Single submitter
- FN3KRP p.Ser300Phe Uncertain significance Single submitter
- FN3KRP p.Thr149Met Uncertain significance Single submitter
- FN3KRP p.Thr17Ser Uncertain significance Single submitter
- FN3KRP p.Tyr263His Uncertain significance Single submitter
- FN3KRP p.Val166Met Uncertain significance Single submitter
Predictors split 25
The independent predictors disagree with each other — read with care.
- FN3KRP p.Ala48Val Uncertain significance Single submitter
- FN3KRP p.Arg142Trp Uncertain significance Single submitter
- FN3KRP p.Arg170Trp Uncertain significance Single submitter
- FN3KRP p.Arg29Trp Uncertain significance Single submitter
- FN3KRP p.Arg37Gly Uncertain significance Single submitter
- FN3KRP p.Arg7His Uncertain significance Single submitter
- FN3KRP p.Arg7Leu Uncertain significance Single submitter
- FN3KRP p.Asp32His Uncertain significance Single submitter
- FN3KRP p.Asp34Gly Uncertain significance Single submitter
- FN3KRP p.Glu8Gly Uncertain significance Single submitter
- FN3KRP p.Gly82Ser Uncertain significance Single submitter
- FN3KRP p.Ile232Met Uncertain significance Single submitter
- FN3KRP p.Lys269Glu Uncertain significance Single submitter
- FN3KRP p.Phe233Leu Uncertain significance Single submitter
- FN3KRP p.Pro155Leu Uncertain significance Single submitter
- FN3KRP p.Pro271Thr Uncertain significance Single submitter
- FN3KRP p.Ser12Ile Uncertain significance Single submitter
- FN3KRP p.Ser227Pro Uncertain significance Single submitter
- FN3KRP p.Ser256Cys Uncertain significance Single submitter
- FN3KRP p.Ser294Leu Uncertain significance Single submitter
- FN3KRP p.Thr17Arg Uncertain significance Single submitter
- FN3KRP p.Thr60Ile Uncertain significance Single submitter
- FN3KRP p.Tyr153Cys Uncertain significance Single submitter
- FN3KRP p.Tyr285Cys Uncertain significance Single submitter
- FN3KRP p.Val147Met Uncertain significance Single submitter
All FN3KRP variants
Likely benign 4
- p.Arg121Leu Single submitter
- p.Arg170Gln Single submitter
- p.Arg6Lys Single submitter
- p.Val85Met Single submitter
Uncertain significance 79
- p.Ala108Pro Single submitter ⚠
- p.Ala108Val Single submitter ⚠
- p.Ala125Thr Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Ala48Val Single submitter ⚠
- p.Arg121Cys Single submitter ⚠
- p.Arg137Gln Single submitter ⚠
- p.Arg137Trp Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg170Trp Single submitter ⚠
- p.Arg187Gly Single submitter ⚠
- p.Arg205His Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg29Trp Single submitter ⚠
- p.Arg37Gly Single submitter ⚠
- p.Arg7His Single submitter ⚠
- p.Arg7Leu Single submitter ⚠
- p.Asn158Ser Single submitter ⚠
- p.Asn287Ser Single submitter ⚠
- p.Asn290Thr Single submitter ⚠
- p.Asp113Gly Single submitter ⚠
- p.Asp32His Single submitter ⚠
- p.Asp34Gly Single submitter ⚠
- p.Asp34His Single submitter
- p.Cys24Ser Single submitter
- p.Gln156Arg Single submitter ⚠
- p.Gln27Glu Single submitter ⚠
- p.Glu119Asp Single submitter ⚠
- p.Glu136Val Single submitter ⚠
- p.Glu55Gly Single submitter ⚠
- p.Glu55Lys Single submitter ⚠
- p.Glu8Gly Single submitter ⚠
- p.Gly10Arg Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Gly133Val Single submitter ⚠
- p.Gly21Arg Single submitter
- p.Gly22Ser Single submitter ⚠
- p.Gly240Ser Single submitter ⚠
- p.Gly28Val Single submitter ⚠
- p.Gly36Arg Single submitter
- p.Gly81Ser Single submitter ⚠
- p.Gly82Ser Single submitter ⚠
- p.Ile232Met Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile303Thr Single submitter ⚠
- p.Leu4Pro Single submitter
- p.Lys102Gln Single submitter ⚠
- p.Lys269Glu Single submitter ⚠
- p.Met251Thr Single submitter ⚠
- p.Met251Val Single submitter
- p.Met304Val Single submitter
- p.Phe143Leu Single submitter ⚠
- p.Phe233Leu Single submitter ⚠
- p.Phe255Ser Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro271Thr Single submitter ⚠
- p.Ser12Ile Single submitter ⚠
- p.Ser194Pro Single submitter ⚠
- p.Ser227Pro Single submitter ⚠
- p.Ser237Tyr Single submitter ⚠
- p.Ser242Leu Single submitter
- p.Ser256Cys Single submitter ⚠
- p.Ser26Asn Single submitter ⚠
- p.Ser294Leu Single submitter ⚠
- p.Ser299Thr Single submitter ⚠
- p.Ser300Phe Single submitter ⚠
- p.Thr149Met Single submitter ⚠
- p.Thr17Arg Single submitter ⚠
- p.Thr17Ser Single submitter ⚠
- p.Thr60Ile Single submitter ⚠
- p.Tyr153Cys Single submitter ⚠
- p.Tyr263His Single submitter ⚠
- p.Tyr285Cys Single submitter ⚠
- p.Val147Met Single submitter ⚠
- p.Val166Met Single submitter ⚠
- p.Val40Met Single submitter
- p.Val87Met Single submitter