FOLR2 — 36 ClinVar variants
All ClinVar germline FOLR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 31 flagged for review →
2 Benign · 3 Likely benign · 31 Uncertain significance
Full FOLR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 31
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 22
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOLR2 p.Ala224Ser Uncertain significance Single submitter
- FOLR2 p.Ala34Val Uncertain significance Single submitter
- FOLR2 p.Arg122Cys Uncertain significance Single submitter
- FOLR2 p.Asn77Ser Uncertain significance Single submitter
- FOLR2 p.Asp23Asn Uncertain significance Single submitter
- FOLR2 p.Cys133Arg Uncertain significance Single submitter
- FOLR2 p.Cys19Tyr Uncertain significance Single submitter
- FOLR2 p.Cys99Ser Uncertain significance Single submitter
- FOLR2 p.Gly239Ala Uncertain significance Single submitter
- FOLR2 p.His228Asn Uncertain significance Single submitter
- FOLR2 p.Leu241Phe Uncertain significance Single submitter
- FOLR2 p.Leu28Phe Uncertain significance Single submitter
- FOLR2 p.Lys46Arg Uncertain significance Single submitter
- FOLR2 p.Met86Thr Uncertain significance Single submitter
- FOLR2 p.Pro177Ala Uncertain significance Single submitter
- FOLR2 p.Pro41Arg Uncertain significance Single submitter
- FOLR2 p.Ser63Gly Uncertain significance Single submitter
- FOLR2 p.Thr61Lys Uncertain significance Single submitter
- FOLR2 p.Thr72Ile Uncertain significance Single submitter
- FOLR2 p.Trp110Ser Uncertain significance Single submitter
- FOLR2 p.Trp207Ser Uncertain significance Single submitter
- FOLR2 p.Val13Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- FOLR2 p.Met86Ile Benign Multiple submitters
- FOLR2 p.Arg92His Uncertain significance Single submitter
- FOLR2 p.Asn216Ser Uncertain significance Single submitter
- FOLR2 p.Gly201Ser Uncertain significance Single submitter
- FOLR2 p.Leu243Pro Uncertain significance Single submitter
- FOLR2 p.Leu253Phe Uncertain significance Single submitter
- FOLR2 p.Trp118Gly Uncertain significance Single submitter
- FOLR2 p.Val13Asp Uncertain significance Single submitter
- FOLR2 p.Val219Met Uncertain significance Single submitter
All FOLR2 variants
Benign 2
- p.Gly84Ser Multiple submitters
- p.Met86Ile Multiple submitters ⚠
Likely benign 3
- p.Asp81= Single submitter
- p.Gln112Arg Single submitter
- p.Leu235Pro Single submitter
Uncertain significance 31
- p.Ala224Ser Single submitter ⚠
- p.Ala34Val Single submitter ⚠
- p.Arg122Cys Single submitter ⚠
- p.Arg92His Single submitter ⚠
- p.Asn216Ser Single submitter ⚠
- p.Asn77Ser Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp81His Single submitter
- p.Cys133Arg Single submitter ⚠
- p.Cys19Tyr Single submitter ⚠
- p.Cys99Ser Single submitter ⚠
- p.Gly201Ser Single submitter ⚠
- p.Gly239Ala Single submitter ⚠
- p.His228Asn Single submitter ⚠
- p.Leu241Phe Single submitter ⚠
- p.Leu243Pro Single submitter ⚠
- p.Leu253Phe Single submitter ⚠
- p.Leu28Phe Single submitter ⚠
- p.Lys46Arg Single submitter ⚠
- p.Met86Thr Single submitter ⚠
- p.Pro177Ala Single submitter ⚠
- p.Pro41Arg Single submitter ⚠
- p.Ser63Gly Single submitter ⚠
- p.Thr61Lys Single submitter ⚠
- p.Thr72Ile Single submitter ⚠
- p.Trp110Ser Single submitter ⚠
- p.Trp118Gly Single submitter ⚠
- p.Trp207Ser Single submitter ⚠
- p.Val13Asp Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val219Met Single submitter ⚠