FOSB — 40 ClinVar variants
All ClinVar germline FOSB variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 36 flagged for review →
1 Benign · 2 Likely benign · 37 Uncertain significance
Full FOSB gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 36
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOSB p.Ala313Thr Uncertain significance Single submitter
- FOSB p.Ala313Val Uncertain significance Single submitter
- FOSB p.Arg139Gln Uncertain significance Single submitter
- FOSB p.Asp181Asn Uncertain significance Single submitter
- FOSB p.Asp181His Uncertain significance Single submitter
- FOSB p.Glu237Lys Uncertain significance Single submitter
- FOSB p.Glu285Lys Uncertain significance Single submitter
- FOSB p.Gly127Arg Uncertain significance Single submitter
- FOSB p.Gly131Arg Uncertain significance Single submitter
- FOSB p.Gly231Glu Uncertain significance Single submitter
- FOSB p.Gly46Cys Uncertain significance Single submitter
- FOSB p.Gly52Ser Uncertain significance Single submitter
- FOSB p.Met79Val Uncertain significance Single submitter
- FOSB p.Pro132Ser Uncertain significance Single submitter
- FOSB p.Pro145Ser Uncertain significance Single submitter
- FOSB p.Pro230Leu Uncertain significance Single submitter
- FOSB p.Pro273Arg Uncertain significance Single submitter
- FOSB p.Pro274Ser Uncertain significance Single submitter
- FOSB p.Pro309Leu Uncertain significance Single submitter
- FOSB p.Ser126Gly Uncertain significance Single submitter
- FOSB p.Ser253Arg Uncertain significance Single submitter
- FOSB p.Ser269Gly Uncertain significance Single submitter
- FOSB p.Thr149Met Uncertain significance Single submitter
- FOSB p.Thr59Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- FOSB p.Ala337Thr Uncertain significance Single submitter
- FOSB p.Arg139Gly Uncertain significance Single submitter
- FOSB p.Asp181Glu Uncertain significance Single submitter
- FOSB p.Asp95Ala Uncertain significance Single submitter
- FOSB p.Glu192Lys Uncertain significance Single submitter
- FOSB p.Ile224Phe Uncertain significance Single submitter
- FOSB p.Ile76Phe Uncertain significance Single submitter
- FOSB p.Leu70Phe Uncertain significance Single submitter
- FOSB p.Ser114Arg Uncertain significance Single submitter
- FOSB p.Ser124Phe Uncertain significance Single submitter
- FOSB p.Ser130Arg Uncertain significance Single submitter
- FOSB p.Ser31Phe Uncertain significance Single submitter
All FOSB variants
Benign 1
- p.Gly33Ser Single submitter
Uncertain significance 37
- p.Ala313Thr Single submitter ⚠
- p.Ala313Val Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Arg139Gln Single submitter ⚠
- p.Arg139Gly Single submitter ⚠
- p.Asp181Asn Single submitter ⚠
- p.Asp181Glu Single submitter ⚠
- p.Asp181His Single submitter ⚠
- p.Asp95Ala Single submitter ⚠
- p.Glu192Lys Single submitter ⚠
- p.Glu237Lys Single submitter ⚠
- p.Glu285Lys Single submitter ⚠
- p.Gly127Arg Single submitter ⚠
- p.Gly131Arg Single submitter ⚠
- p.Gly231Glu Single submitter ⚠
- p.Gly46Cys Single submitter ⚠
- p.Gly52Ser Single submitter ⚠
- p.Ile224Phe Single submitter ⚠
- p.Ile76Phe Single submitter ⚠
- p.Leu70Phe Single submitter ⚠
- p.Met79Val Single submitter ⚠
- p.Pro132Ser Single submitter ⚠
- p.Pro145Ser Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro273Arg Single submitter ⚠
- p.Pro274Ser Single submitter ⚠
- p.Pro309Leu Single submitter ⚠
- p.Ser114Arg Single submitter ⚠
- p.Ser124Phe Single submitter ⚠
- p.Ser126Gly Single submitter ⚠
- p.Ser130Arg Single submitter ⚠
- p.Ser253Arg Single submitter ⚠
- p.Ser269Gly Single submitter ⚠
- p.Ser31Phe Single submitter ⚠
- p.Thr149Met Single submitter ⚠
- p.Thr59Ile Single submitter ⚠
- p.Thr74Ala Single submitter