Sugi Variant

Sugi Variant/FOXH1

FOXH1 — 280 ClinVar variants

All ClinVar germline FOXH1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 167 flagged for review →

6 Likely pathogenic · 10 Conflicting · 15 Benign · 9 Benign/Likely benign · 50 Likely benign · 190 Uncertain significance

Full FOXH1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 167

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 141

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All FOXH1 variants

Likely pathogenic 6

Conflicting classifications of pathogenicity 10

Benign 15

Benign/Likely benign 9

Likely benign 50

Uncertain significance 190