FOXM1 — 123 ClinVar variants
All ClinVar germline FOXM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 103 flagged for review →
10 Benign · 1 Benign/Likely benign · 8 Likely benign · 104 Uncertain significance
Full FOXM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 103
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 86
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOXM1 p.Ala147Asp Uncertain significance Single submitter
- FOXM1 p.Ala147Ser Uncertain significance Single submitter
- FOXM1 p.Ala158Val Uncertain significance Single submitter
- FOXM1 p.Ala227Val Uncertain significance Single submitter
- FOXM1 p.Ala474Val Uncertain significance Single submitter
- FOXM1 p.Arg122Trp Uncertain significance Single submitter
- FOXM1 p.Arg164Gln Uncertain significance Single submitter
- FOXM1 p.Arg198His Uncertain significance Single submitter
- FOXM1 p.Arg256Cys Uncertain significance Single submitter
- FOXM1 p.Arg256His Uncertain significance Single submitter
- FOXM1 p.Arg350His Uncertain significance Single submitter
- FOXM1 p.Arg412Cys Uncertain significance Single submitter
- FOXM1 p.Arg412His Uncertain significance Single submitter
- FOXM1 p.Arg418Cys Uncertain significance Single submitter
- FOXM1 p.Arg543Gln Uncertain significance Single submitter
- FOXM1 p.Arg543Trp Uncertain significance Single submitter
- FOXM1 p.Arg570Cys Uncertain significance Single submitter
- FOXM1 p.Arg6His Uncertain significance Single submitter
- FOXM1 p.Arg716His Uncertain significance Single submitter
- FOXM1 p.Asn151His Uncertain significance Single submitter
- FOXM1 p.Asn715Ser Uncertain significance Single submitter
- FOXM1 p.Asn72Ser Uncertain significance Single submitter
- FOXM1 p.Asp149Val Uncertain significance Single submitter
- FOXM1 p.Asp580Asn Uncertain significance Single submitter
- FOXM1 p.Cys554Arg Uncertain significance Single submitter
- FOXM1 p.Cys554Phe Uncertain significance Single submitter
- FOXM1 p.Cys56Trp Uncertain significance Single submitter
- FOXM1 p.Gln117Lys Uncertain significance Single submitter
- FOXM1 p.Gln216His Uncertain significance Single submitter
- FOXM1 p.Gln387His Uncertain significance Single submitter
- FOXM1 p.Gln644Arg Uncertain significance Single submitter
- FOXM1 p.Gln708Arg Uncertain significance Single submitter
- FOXM1 p.Glu26Lys Uncertain significance Single submitter
- FOXM1 p.Glu336Lys Uncertain significance Single submitter
- FOXM1 p.Glu409Gly Uncertain significance Single submitter
- FOXM1 p.Glu486Lys Uncertain significance Single submitter
- FOXM1 p.Glu557Lys Uncertain significance Single submitter
- FOXM1 p.Glu671Ala Uncertain significance Single submitter
- FOXM1 p.Gly142Glu Uncertain significance Single submitter
- FOXM1 p.Gly447Arg Uncertain significance Single submitter
- FOXM1 p.Gly565Glu Uncertain significance Single submitter
- FOXM1 p.His275Tyr Uncertain significance Single submitter
- FOXM1 p.Ile200Thr Uncertain significance Single submitter
- FOXM1 p.Leu121Val Uncertain significance Single submitter
- FOXM1 p.Leu444Pro Uncertain significance Single submitter
- FOXM1 p.Leu606Pro Uncertain significance Single submitter
- FOXM1 p.Leu617Ile Uncertain significance Single submitter
- FOXM1 p.Leu659Phe Uncertain significance Single submitter
- FOXM1 p.Leu684Phe Uncertain significance Single submitter
- FOXM1 p.Lys189Asn Uncertain significance Single submitter
- FOXM1 p.Met204Thr Uncertain significance Single submitter
- FOXM1 p.Phe689Ser Uncertain significance Single submitter
- FOXM1 p.Pro24Leu Uncertain significance Single submitter
- FOXM1 p.Pro432Arg Uncertain significance Single submitter
- FOXM1 p.Pro483Leu Uncertain significance Single submitter
- FOXM1 p.Pro488Leu Uncertain significance Single submitter
- FOXM1 p.Pro492Leu Uncertain significance Single submitter
- FOXM1 p.Pro511Ala Uncertain significance Single submitter
- FOXM1 p.Pro566Arg Uncertain significance Single submitter
- FOXM1 p.Pro584Thr Uncertain significance Single submitter
- FOXM1 p.Pro649Ala Uncertain significance Single submitter
- FOXM1 p.Pro668His Uncertain significance Single submitter
- FOXM1 p.Pro669His Uncertain significance Single submitter
- FOXM1 p.Pro68His Uncertain significance Single submitter
- FOXM1 p.Pro694Leu Uncertain significance Single submitter
- FOXM1 p.Pro705Leu Uncertain significance Single submitter
- FOXM1 p.Pro750Leu Uncertain significance Single submitter
- FOXM1 p.Ser223Leu Uncertain significance Single submitter
- FOXM1 p.Ser394Leu Uncertain significance Single submitter
- FOXM1 p.Ser41Ala Uncertain significance Single submitter
- FOXM1 p.Ser499Pro Uncertain significance Single submitter
- FOXM1 p.Ser506Tyr Uncertain significance Single submitter
- FOXM1 p.Ser528Leu Uncertain significance Single submitter
- FOXM1 p.Ser528Trp Uncertain significance Single submitter
- FOXM1 p.Ser567Arg Uncertain significance Single submitter
- FOXM1 p.Ser643Phe Uncertain significance Single submitter
- FOXM1 p.Ser666Gly Uncertain significance Single submitter
- FOXM1 p.Ser679Leu Uncertain significance Single submitter
- FOXM1 p.Thr166Asn Uncertain significance Single submitter
- FOXM1 p.Thr27Ile Uncertain significance Single submitter
- FOXM1 p.Thr458Ile Uncertain significance Single submitter
- FOXM1 p.Thr510Asn Uncertain significance Single submitter
- FOXM1 p.Thr600Ile Uncertain significance Single submitter
- FOXM1 p.Tyr517Cys Uncertain significance Single submitter
- FOXM1 p.Val423Leu Uncertain significance Single submitter
- FOXM1 p.Val555Gly Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- FOXM1 p.Ser180Arg Benign Multiple submitters
- FOXM1 p.Ala82Gly Uncertain significance Single submitter
- FOXM1 p.Arg545Gly Uncertain significance Single submitter
- FOXM1 p.Arg545Trp Uncertain significance Single submitter
- FOXM1 p.Arg7Pro Uncertain significance Single submitter
- FOXM1 p.Asp293Glu Uncertain significance Single submitter
- FOXM1 p.Gln548Glu Uncertain significance Single submitter
- FOXM1 p.Leu195Pro Uncertain significance Single submitter
- FOXM1 p.Leu762Pro Uncertain significance Single submitter
- FOXM1 p.Met70Thr Uncertain significance Single submitter
- FOXM1 p.Pro558Leu Uncertain significance Single submitter
- FOXM1 p.Pro607Thr Uncertain significance Single submitter
- FOXM1 p.Pro639Ala Uncertain significance Single submitter
- FOXM1 p.Pro639Ser Uncertain significance Single submitter
- FOXM1 p.Pro688Arg Uncertain significance Single submitter
- FOXM1 p.Ser609Phe Uncertain significance Single submitter
- FOXM1 p.Thr73Met Uncertain significance Single submitter
All FOXM1 variants
Benign 10
- c.1091-5C>T Multiple submitters
- p.Arg297= Multiple submitters
- p.Arg6Cys Multiple submitters
- p.Pro335= Multiple submitters
- p.Pro669Arg Multiple submitters
- p.Ser180Arg Multiple submitters ⚠
- p.Arg546= Single submitter
- p.Pro668Thr Single submitter
- p.Ser284= Single submitter
- p.Val555= Single submitter
Benign/Likely benign 1
- p.Ser394= Multiple submitters
Likely benign 8
- p.Pro673Leu Multiple submitters
- p.Thr627= Multiple submitters
- p.Ala573Thr Single submitter
- p.Arg122Gln Single submitter
- p.Arg164Trp Single submitter
- p.Asn754Ser Single submitter
- p.Pro669Leu Single submitter
- p.Thr605Met Single submitter
Uncertain significance 104
- p.Ala147Asp Single submitter ⚠
- p.Ala147Ser Single submitter ⚠
- p.Ala158Val Single submitter ⚠
- p.Ala227Val Single submitter ⚠
- p.Ala474Val Single submitter ⚠
- p.Ala82Gly Single submitter ⚠
- p.Arg122Trp Single submitter ⚠
- p.Arg164Gln Single submitter ⚠
- p.Arg198His Single submitter ⚠
- p.Arg256Cys Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Arg350His Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg412His Single submitter ⚠
- p.Arg418Cys Single submitter ⚠
- p.Arg543Gln Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg545Gly Single submitter ⚠
- p.Arg545Trp Single submitter ⚠
- p.Arg570Cys Single submitter ⚠
- p.Arg6His Single submitter ⚠
- p.Arg716His Single submitter ⚠
- p.Arg7Pro Single submitter ⚠
- p.Asn151His Single submitter ⚠
- p.Asn715Ser Single submitter ⚠
- p.Asn72Lys Single submitter
- p.Asn72Ser Single submitter ⚠
- p.Asp149Val Single submitter ⚠
- p.Asp293Glu Single submitter ⚠
- p.Asp580Asn Single submitter ⚠
- p.Cys554Arg Single submitter ⚠
- p.Cys554Phe Single submitter ⚠
- p.Cys56Trp Single submitter ⚠
- p.Gln117Lys Single submitter ⚠
- p.Gln216His Single submitter ⚠
- p.Gln387His Single submitter ⚠
- p.Gln548Glu Single submitter ⚠
- p.Gln644Arg Single submitter ⚠
- p.Gln708Arg Single submitter ⚠
- p.Glu26Lys Single submitter ⚠
- p.Glu336Lys Single submitter ⚠
- p.Glu409Gly Single submitter ⚠
- p.Glu486Lys Single submitter ⚠
- p.Glu557Lys Single submitter ⚠
- p.Glu671Ala Single submitter ⚠
- p.Gly142Glu Single submitter ⚠
- p.Gly447Arg Single submitter ⚠
- p.Gly565Glu Single submitter ⚠
- p.His275Tyr Single submitter ⚠
- p.Ile200Thr Single submitter ⚠
- p.Ile419Val Single submitter
- p.Leu121Val Single submitter ⚠
- p.Leu195Pro Single submitter ⚠
- p.Leu444Pro Single submitter ⚠
- p.Leu606Pro Single submitter ⚠
- p.Leu617Ile Single submitter ⚠
- p.Leu659Phe Single submitter ⚠
- p.Leu684Phe Single submitter ⚠
- p.Leu762Pro Single submitter ⚠
- p.Lys189Asn Single submitter ⚠
- p.Met204Thr Single submitter ⚠
- p.Met70Thr Single submitter ⚠
- p.Phe689Ser Single submitter ⚠
- p.Pro24Leu Single submitter ⚠
- p.Pro432Arg Single submitter ⚠
- p.Pro483Leu Single submitter ⚠
- p.Pro488Leu Single submitter ⚠
- p.Pro492Leu Single submitter ⚠
- p.Pro511Ala Single submitter ⚠
- p.Pro558Leu Single submitter ⚠
- p.Pro566Arg Single submitter ⚠
- p.Pro584Thr Single submitter ⚠
- p.Pro607Thr Single submitter ⚠
- p.Pro639Ala Single submitter ⚠
- p.Pro639Ser Single submitter ⚠
- p.Pro649Ala Single submitter ⚠
- p.Pro668His Single submitter ⚠
- p.Pro669His Single submitter ⚠
- p.Pro688Arg Single submitter ⚠
- p.Pro68His Single submitter ⚠
- p.Pro694Leu Single submitter ⚠
- p.Pro705Leu Single submitter ⚠
- p.Pro750Leu Single submitter ⚠
- p.Ser223Leu Single submitter ⚠
- p.Ser394Leu Single submitter ⚠
- p.Ser41Ala Single submitter ⚠
- p.Ser499Pro Single submitter ⚠
- p.Ser506Tyr Single submitter ⚠
- p.Ser528Leu Single submitter ⚠
- p.Ser528Trp Single submitter ⚠
- p.Ser567Arg Single submitter ⚠
- p.Ser609Phe Single submitter ⚠
- p.Ser643Phe Single submitter ⚠
- p.Ser666Gly Single submitter ⚠
- p.Ser679Leu Single submitter ⚠
- p.Thr166Asn Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Thr458Ile Single submitter ⚠
- p.Thr510Asn Single submitter ⚠
- p.Thr600Ile Single submitter ⚠
- p.Thr73Met Single submitter ⚠
- p.Tyr517Cys Single submitter ⚠
- p.Val423Leu Single submitter ⚠
- p.Val555Gly Single submitter ⚠