FOXO1 — 84 ClinVar variants
All ClinVar germline FOXO1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 69 flagged for review →
1 Pathogenic · 3 Benign · 1 Benign/Likely benign · 6 Likely benign · 73 Uncertain significance
Full FOXO1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 69
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOXO1 p.Ala101Thr Uncertain significance Single submitter
- FOXO1 p.Ala255Val Uncertain significance Single submitter
- FOXO1 p.Ala356Thr Uncertain significance Single submitter
- FOXO1 p.Ala511Ser Uncertain significance Single submitter
- FOXO1 p.Ala533Ser Uncertain significance Single submitter
- FOXO1 p.Ala92Val Uncertain significance Single submitter
- FOXO1 p.Ala99Val Uncertain significance Single submitter
- FOXO1 p.Arg267Gln Uncertain significance Single submitter
- FOXO1 p.Arg490Trp Uncertain significance Single submitter
- FOXO1 p.Asn304Ser Uncertain significance Single submitter
- FOXO1 p.Asn445Lys Uncertain significance Single submitter
- FOXO1 p.Asn488Ser Uncertain significance Single submitter
- FOXO1 p.Asn585Ser Uncertain significance Single submitter
- FOXO1 p.Asp626Glu Uncertain significance Single submitter
- FOXO1 p.Cys107Arg Uncertain significance Single submitter
- FOXO1 p.Gln111Arg Uncertain significance Single submitter
- FOXO1 p.Gly112Cys Uncertain significance Single submitter
- FOXO1 p.Gly112Val Uncertain significance Single submitter
- FOXO1 p.Gly300Val Uncertain significance Single submitter
- FOXO1 p.Gly499Cys Uncertain significance Single submitter
- FOXO1 p.Gly604Asp Uncertain significance Single submitter
- FOXO1 p.His513Tyr Uncertain significance Single submitter
- FOXO1 p.His522Asp Uncertain significance Single submitter
- FOXO1 p.His527Tyr Uncertain significance Single submitter
- FOXO1 p.His548Arg Uncertain significance Single submitter
- FOXO1 p.Met399Ile Uncertain significance Single submitter
- FOXO1 p.Met570Val Uncertain significance Single submitter
- FOXO1 p.Met71Val Uncertain significance Single submitter
- FOXO1 p.Phe32Tyr Uncertain significance Single submitter
- FOXO1 p.Phe32Val Uncertain significance Single submitter
- FOXO1 p.Pro138Leu Uncertain significance Single submitter
- FOXO1 p.Pro438Thr Uncertain significance Single submitter
- FOXO1 p.Pro472Ser Uncertain significance Single submitter
- FOXO1 p.Pro487Ser Uncertain significance Single submitter
- FOXO1 p.Pro525Arg Uncertain significance Single submitter
- FOXO1 p.Ser155Cys Uncertain significance Single submitter
- FOXO1 p.Ser322Thr Uncertain significance Single submitter
- FOXO1 p.Ser33Thr Uncertain significance Single submitter
- FOXO1 p.Ser357Ala Uncertain significance Single submitter
- FOXO1 p.Ser366Asn Uncertain significance Single submitter
- FOXO1 p.Ser366Gly Uncertain significance Single submitter
- FOXO1 p.Ser37Leu Uncertain significance Single submitter
- FOXO1 p.Ser37Pro Uncertain significance Single submitter
- FOXO1 p.Ser394Leu Uncertain significance Single submitter
- FOXO1 p.Ser416Leu Uncertain significance Single submitter
- FOXO1 p.Ser448Gly Uncertain significance Single submitter
- FOXO1 p.Ser550Ala Uncertain significance Single submitter
- FOXO1 p.Thr103Pro Uncertain significance Single submitter
- FOXO1 p.Thr103Ser Uncertain significance Single submitter
- FOXO1 p.Thr397Asn Uncertain significance Single submitter
- FOXO1 p.Thr425Ile Uncertain significance Single submitter
- FOXO1 p.Thr506Ile Uncertain significance Single submitter
- FOXO1 p.Thr648Ala Uncertain significance Single submitter
- FOXO1 p.Tyr449Cys Uncertain significance Single submitter
- FOXO1 p.Tyr455Cys Uncertain significance Single submitter
- FOXO1 p.Val496Ile Uncertain significance Single submitter
- FOXO1 p.Val564Gly Uncertain significance Single submitter
- FOXO1 p.Val581Met Uncertain significance Single submitter
- FOXO1 p.Val90Gly Uncertain significance Single submitter
- FOXO1 p.Val90Leu Uncertain significance Single submitter
- FOXO1 p.Val94Gly Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- FOXO1 p.Asp306Ala Uncertain significance Single submitter
- FOXO1 p.Gln400Leu Uncertain significance Single submitter
- FOXO1 p.Gly283Val Uncertain significance Single submitter
- FOXO1 p.Gly586Asp Uncertain significance Single submitter
- FOXO1 p.Gly591Asp Uncertain significance Single submitter
- FOXO1 p.His594Arg Uncertain significance Single submitter
- FOXO1 p.Ser293Cys Uncertain significance Single submitter
- FOXO1 p.Val480Phe Uncertain significance Single submitter
All FOXO1 variants
Pathogenic 1
- p.Gly161Asp No assertion criteria diffuse large B-cell lymphoma
Benign 3
- c.*1254G>A Multiple submitters
- p.Phe307= Multiple submitters
- p.Ser502= Multiple submitters
Benign/Likely benign 1
- p.Thr333= Multiple submitters
Likely benign 6
- p.Pro126= Single submitter
- p.Pro18= Single submitter
- p.Pro540Ser Single submitter
- p.Ser453Asn Single submitter
- p.Thr542Ala Single submitter
- p.Gly104Ala No assertion criteria FOXO1-related disorder
Uncertain significance 73
- p.Ala101Thr Single submitter ⚠
- p.Ala255Val Single submitter ⚠
- p.Ala356Thr Single submitter ⚠
- p.Ala511Ser Single submitter ⚠
- p.Ala533Ser Single submitter ⚠
- p.Ala92Val Single submitter ⚠
- p.Ala99Val Single submitter ⚠
- p.Arg267Gln Single submitter ⚠
- p.Arg490Trp Single submitter ⚠
- p.Asn304Ser Single submitter ⚠
- p.Asn445Lys Single submitter ⚠
- p.Asn488Ser Single submitter ⚠
- p.Asn553fs Single submitter
- p.Asn585Ser Single submitter ⚠
- p.Asp306Ala Single submitter ⚠
- p.Asp626Glu Single submitter ⚠
- p.Cys107Arg Single submitter ⚠
- p.Gln111Arg Single submitter ⚠
- p.Gln400Leu Single submitter ⚠
- p.Gly112Cys Single submitter ⚠
- p.Gly112Val Single submitter ⚠
- p.Gly283Val Single submitter ⚠
- p.Gly300Val Single submitter ⚠
- p.Gly460Arg Single submitter
- p.Gly499Cys Single submitter ⚠
- p.Gly586Asp Single submitter ⚠
- p.Gly591Asp Single submitter ⚠
- p.Gly604Asp Single submitter ⚠
- p.His302fs Single submitter
- p.His513Tyr Single submitter ⚠
- p.His522Asp Single submitter ⚠
- p.His527Tyr Single submitter ⚠
- p.His548Arg Single submitter ⚠
- p.His594Arg Single submitter ⚠
- p.Met399Ile Single submitter ⚠
- p.Met570Val Single submitter ⚠
- p.Met71Val Single submitter ⚠
- p.Phe32Tyr Single submitter ⚠
- p.Phe32Val Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro438Thr Single submitter ⚠
- p.Pro472Ser Single submitter ⚠
- p.Pro487Ser Single submitter ⚠
- p.Pro525Arg Single submitter ⚠
- p.Ser155Cys Single submitter ⚠
- p.Ser293Cys Single submitter ⚠
- p.Ser322Thr Single submitter ⚠
- p.Ser33Thr Single submitter ⚠
- p.Ser357Ala Single submitter ⚠
- p.Ser366Asn Single submitter ⚠
- p.Ser366Gly Single submitter ⚠
- p.Ser37Leu Single submitter ⚠
- p.Ser37Pro Single submitter ⚠
- p.Ser394Leu Single submitter ⚠
- p.Ser416Leu Single submitter ⚠
- p.Ser448Gly Single submitter ⚠
- p.Ser550Ala Single submitter ⚠
- p.Thr103Pro Single submitter ⚠
- p.Thr103Ser Single submitter ⚠
- p.Thr397Asn Single submitter ⚠
- p.Thr425Ile Single submitter ⚠
- p.Thr506Ile Single submitter ⚠
- p.Thr648Ala Single submitter ⚠
- p.Trp310Ter Single submitter
- p.Tyr449Cys Single submitter ⚠
- p.Tyr455Cys Single submitter ⚠
- p.Val480Phe Single submitter ⚠
- p.Val496Ile Single submitter ⚠
- p.Val564Gly Single submitter ⚠
- p.Val581Met Single submitter ⚠
- p.Val90Gly Single submitter ⚠
- p.Val90Leu Single submitter ⚠
- p.Val94Gly Single submitter ⚠