FOXO3 — 97 ClinVar variants
All ClinVar germline FOXO3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 81 flagged for review →
8 Benign · 6 Likely benign · 83 Uncertain significance
Full FOXO3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 81
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 73
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FOXO3 p.Ala113Val Uncertain significance Single submitter
- FOXO3 p.Ala125Val Uncertain significance Single submitter
- FOXO3 p.Ala281Thr Uncertain significance Single submitter
- FOXO3 p.Ala305Val Uncertain significance Single submitter
- FOXO3 p.Ala341Gly Uncertain significance Single submitter
- FOXO3 p.Ala53Thr Uncertain significance Single submitter
- FOXO3 p.Ala665Pro Uncertain significance Single submitter
- FOXO3 p.Ala6Ser Uncertain significance Single submitter
- FOXO3 p.Ala76Thr Uncertain significance Single submitter
- FOXO3 p.Arg249Gln Uncertain significance Single submitter
- FOXO3 p.Arg27Cys Uncertain significance Single submitter
- FOXO3 p.Arg310Cys Uncertain significance Single submitter
- FOXO3 p.Arg37Ser Uncertain significance Single submitter
- FOXO3 p.Arg548Cys Uncertain significance Single submitter
- FOXO3 p.Asn256Ser Uncertain significance Single submitter
- FOXO3 p.Gln25Arg Uncertain significance Single submitter
- FOXO3 p.Gln409Arg Uncertain significance Single submitter
- FOXO3 p.Glu17Gly Uncertain significance Single submitter
- FOXO3 p.Glu50Asp Uncertain significance Single submitter
- FOXO3 p.Glu59Lys Uncertain significance Single submitter
- FOXO3 p.Glu67Gly Uncertain significance Single submitter
- FOXO3 p.Gly105Glu Uncertain significance Single submitter
- FOXO3 p.Gly139Ala Uncertain significance Single submitter
- FOXO3 p.Gly143Val Uncertain significance Single submitter
- FOXO3 p.Gly265Val Uncertain significance Single submitter
- FOXO3 p.Gly49Glu Uncertain significance Single submitter
- FOXO3 p.Gly74Ser Uncertain significance Single submitter
- FOXO3 p.Gly89Val Uncertain significance Single submitter
- FOXO3 p.His464Arg Uncertain significance Single submitter
- FOXO3 p.Leu119Gln Uncertain significance Single submitter
- FOXO3 p.Leu11Arg Uncertain significance Single submitter
- FOXO3 p.Leu18Val Uncertain significance Single submitter
- FOXO3 p.Leu347Val Uncertain significance Single submitter
- FOXO3 p.Leu354Arg Uncertain significance Single submitter
- FOXO3 p.Leu559Trp Uncertain significance Single submitter
- FOXO3 p.Leu88Arg Uncertain significance Single submitter
- FOXO3 p.Lys262Glu Uncertain significance Single submitter
- FOXO3 p.Met387Leu Uncertain significance Single submitter
- FOXO3 p.Met408Thr Uncertain significance Single submitter
- FOXO3 p.Met462Val Uncertain significance Single submitter
- FOXO3 p.Met516Val Uncertain significance Single submitter
- FOXO3 p.Met557Thr Uncertain significance Single submitter
- FOXO3 p.Met557Val Uncertain significance Single submitter
- FOXO3 p.Pro112Leu Uncertain significance Single submitter
- FOXO3 p.Pro135Leu Uncertain significance Single submitter
- FOXO3 p.Pro138Leu Uncertain significance Single submitter
- FOXO3 p.Pro285Ser Uncertain significance Single submitter
- FOXO3 p.Pro5Leu Uncertain significance Single submitter
- FOXO3 p.Pro5Ser Uncertain significance Single submitter
- FOXO3 p.Ser144Cys Uncertain significance Single submitter
- FOXO3 p.Ser321Gly Uncertain significance Single submitter
- FOXO3 p.Ser357Leu Uncertain significance Single submitter
- FOXO3 p.Ser428Asn Uncertain significance Single submitter
- FOXO3 p.Ser429Cys Uncertain significance Single submitter
- FOXO3 p.Ser429Phe Uncertain significance Single submitter
- FOXO3 p.Ser527Cys Uncertain significance Single submitter
- FOXO3 p.Ser527Gly Uncertain significance Single submitter
- FOXO3 p.Ser667Cys Uncertain significance Single submitter
- FOXO3 p.Ser90Cys Uncertain significance Single submitter
- FOXO3 p.Thr261Ala Uncertain significance Single submitter
- FOXO3 p.Thr261Ile Uncertain significance Single submitter
- FOXO3 p.Thr276Ala Uncertain significance Single submitter
- FOXO3 p.Thr331Ala Uncertain significance Single submitter
- FOXO3 p.Thr418Ile Uncertain significance Single submitter
- FOXO3 p.Thr51Ala Uncertain significance Single submitter
- FOXO3 p.Thr51Met Uncertain significance Single submitter
- FOXO3 p.Thr540Ile Uncertain significance Single submitter
- FOXO3 p.Thr582Asn Uncertain significance Single submitter
- FOXO3 p.Val16Leu Uncertain significance Single submitter
- FOXO3 p.Val191Met Uncertain significance Single submitter
- FOXO3 p.Val364Leu Uncertain significance Single submitter
- FOXO3 p.Val484Ile Uncertain significance Single submitter
- FOXO3 p.Val656Met Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- FOXO3 p.Arg410Trp Uncertain significance Single submitter
- FOXO3 p.Asp639Glu Uncertain significance Single submitter
- FOXO3 p.Gly145Arg Uncertain significance Single submitter
- FOXO3 p.His481Tyr Uncertain significance Single submitter
- FOXO3 p.Met493Ile Uncertain significance Single submitter
- FOXO3 p.Pro20Leu Uncertain significance Single submitter
- FOXO3 p.Pro447Ala Uncertain significance Single submitter
- FOXO3 p.Ser413Cys Uncertain significance Single submitter
All FOXO3 variants
Benign 8
- c.621+25486G>T Single submitter
- c.*2326T>C Single submitter
- c.*35-288A>G Single submitter
- p.Ala140Val Single submitter
- p.Ala341Thr Single submitter
- p.Arg168= Single submitter
- p.Arg249= Single submitter
- p.Thr395= Single submitter
Likely benign 6
- p.Ala125Thr Single submitter
- p.Asn513Ser Single submitter
- p.Ser144= Single submitter
- p.Thr498= Single submitter
- p.Thr595Ala Single submitter
- p.Val100Leu Single submitter
Uncertain significance 83
- p.Ala113Val Single submitter ⚠
- p.Ala125Val Single submitter ⚠
- p.Ala281Thr Single submitter ⚠
- p.Ala305Val Single submitter ⚠
- p.Ala341Gly Single submitter ⚠
- p.Ala53Thr Single submitter ⚠
- p.Ala665Pro Single submitter ⚠
- p.Ala6Ser Single submitter ⚠
- p.Ala76Thr Single submitter ⚠
- p.Arg249Gln Single submitter ⚠
- p.Arg27Cys Single submitter ⚠
- p.Arg310Cys Single submitter ⚠
- p.Arg310His Single submitter
- p.Arg37Ser Single submitter ⚠
- p.Arg410Trp Single submitter ⚠
- p.Arg548Cys Single submitter ⚠
- p.Asn256Ser Single submitter ⚠
- p.Asp639Glu Single submitter ⚠
- p.Gln25Arg Single submitter ⚠
- p.Gln409Arg Single submitter ⚠
- p.Glu17Gly Single submitter ⚠
- p.Glu50Asp Single submitter ⚠
- p.Glu59Lys Single submitter ⚠
- p.Glu67Gly Single submitter ⚠
- p.Gly105Glu Single submitter ⚠
- p.Gly139Ala Single submitter ⚠
- p.Gly143Val Single submitter ⚠
- p.Gly145Arg Single submitter ⚠
- p.Gly265Val Single submitter ⚠
- p.Gly49Glu Single submitter ⚠
- p.Gly74Ser Single submitter ⚠
- p.Gly89Val Single submitter ⚠
- p.His464Arg Single submitter ⚠
- p.His481Tyr Single submitter ⚠
- p.Leu119Gln Single submitter ⚠
- p.Leu11Arg Single submitter ⚠
- p.Leu18Val Single submitter ⚠
- p.Leu347Val Single submitter ⚠
- p.Leu354Arg Single submitter ⚠
- p.Leu559Trp Single submitter ⚠
- p.Leu88Arg Single submitter ⚠
- p.Lys262Glu Single submitter ⚠
- p.Met387Leu Single submitter ⚠
- p.Met408Thr Single submitter ⚠
- p.Met462Val Single submitter ⚠
- p.Met493Ile Single submitter ⚠
- p.Met516Val Single submitter ⚠
- p.Met557Thr Single submitter ⚠
- p.Met557Val Single submitter ⚠
- p.Pro112Leu Single submitter ⚠
- p.Pro135Leu Single submitter ⚠
- p.Pro138Leu Single submitter ⚠
- p.Pro20Leu Single submitter ⚠
- p.Pro285Ser Single submitter ⚠
- p.Pro447Ala Single submitter ⚠
- p.Pro5Leu Single submitter ⚠
- p.Pro5Ser Single submitter ⚠
- p.Ser144Cys Single submitter ⚠
- p.Ser321Gly Single submitter ⚠
- p.Ser357Leu Single submitter ⚠
- p.Ser413Cys Single submitter ⚠
- p.Ser428Asn Single submitter ⚠
- p.Ser429Cys Single submitter ⚠
- p.Ser429Phe Single submitter ⚠
- p.Ser527Cys Single submitter ⚠
- p.Ser527Gly Single submitter ⚠
- p.Ser667Cys Single submitter ⚠
- p.Ser90Cys Single submitter ⚠
- p.Thr261Ala Single submitter ⚠
- p.Thr261Ile Single submitter ⚠
- p.Thr276Ala Single submitter ⚠
- p.Thr331Ala Single submitter ⚠
- p.Thr418Ile Single submitter ⚠
- p.Thr51Ala Single submitter ⚠
- p.Thr51Met Single submitter ⚠
- p.Thr540Ile Single submitter ⚠
- p.Thr582Asn Single submitter ⚠
- p.Val100fs Single submitter
- p.Val16Leu Single submitter ⚠
- p.Val191Met Single submitter ⚠
- p.Val364Leu Single submitter ⚠
- p.Val484Ile Single submitter ⚠
- p.Val656Met Single submitter ⚠