FPGS — 78 ClinVar variants
All ClinVar germline FPGS variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Benign · 9 Likely benign · 67 Uncertain significance
Full FPGS gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 59
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FPGS p.Ala10Ser Uncertain significance Single submitter
- FPGS p.Ala15Gly Uncertain significance Single submitter
- FPGS p.Ala19Gly Uncertain significance Single submitter
- FPGS p.Ala307Ser Uncertain significance Single submitter
- FPGS p.Ala395Thr Uncertain significance Single submitter
- FPGS p.Ala423Gly Uncertain significance Single submitter
- FPGS p.Ala451Thr Uncertain significance Single submitter
- FPGS p.Ala4Val Uncertain significance Single submitter
- FPGS p.Ala503Thr Uncertain significance Single submitter
- FPGS p.Ala512Pro Uncertain significance Single submitter
- FPGS p.Ala554Pro Uncertain significance Single submitter
- FPGS p.Arg158Cys Uncertain significance Single submitter
- FPGS p.Arg179Cys Uncertain significance Single submitter
- FPGS p.Arg30Gln Uncertain significance Single submitter
- FPGS p.Arg332Ser Uncertain significance Single submitter
- FPGS p.Arg368Gln Uncertain significance Single submitter
- FPGS p.Arg369His Uncertain significance Single submitter
- FPGS p.Arg50His Uncertain significance Single submitter
- FPGS p.Arg5Trp Uncertain significance Single submitter
- FPGS p.Arg67His Uncertain significance Single submitter
- FPGS p.Arg69Gln Uncertain significance Single submitter
- FPGS p.Asn143Ser Uncertain significance Single submitter
- FPGS p.Gln145Arg Uncertain significance Single submitter
- FPGS p.Gln271Arg Uncertain significance Single submitter
- FPGS p.Gln386His Uncertain significance Single submitter
- FPGS p.Gln394Arg Uncertain significance Single submitter
- FPGS p.Gln397Arg Uncertain significance Single submitter
- FPGS p.Gln68Pro Uncertain significance Single submitter
- FPGS p.Gly404Cys Uncertain significance Single submitter
- FPGS p.Gly495Ser Uncertain significance Single submitter
- FPGS p.Gly543Ser Uncertain significance Single submitter
- FPGS p.His314Asn Uncertain significance Single submitter
- FPGS p.His547Gln Uncertain significance Single submitter
- FPGS p.His7Tyr Uncertain significance Single submitter
- FPGS p.Leu336Pro Uncertain significance Single submitter
- FPGS p.Leu557His Uncertain significance Single submitter
- FPGS p.Leu62Pro Uncertain significance Single submitter
- FPGS p.Lys542Glu Uncertain significance Single submitter
- FPGS p.Met282Ile Uncertain significance Single submitter
- FPGS p.Met351Thr Uncertain significance Single submitter
- FPGS p.Met79Thr Uncertain significance Single submitter
- FPGS p.Pro131Ser Uncertain significance Single submitter
- FPGS p.Pro292Arg Uncertain significance Single submitter
- FPGS p.Pro402Ala Uncertain significance Single submitter
- FPGS p.Pro402Ser Uncertain significance Single submitter
- FPGS p.Pro494Leu Uncertain significance Single submitter
- FPGS p.Pro504Arg Uncertain significance Single submitter
- FPGS p.Pro533Ser Uncertain significance Single submitter
- FPGS p.Ser109Thr Uncertain significance Single submitter
- FPGS p.Ser223Cys Uncertain significance Single submitter
- FPGS p.Ser383Cys Uncertain significance Single submitter
- FPGS p.Ser491Asn Uncertain significance Single submitter
- FPGS p.Ser511Thr Uncertain significance Single submitter
- FPGS p.Thr102Ser Uncertain significance Single submitter
- FPGS p.Thr74Pro Uncertain significance Single submitter
- FPGS p.Val188Ile Uncertain significance Single submitter
- FPGS p.Val201Ala Uncertain significance Single submitter
- FPGS p.Val26Gly Uncertain significance Single submitter
- FPGS p.Val437Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FPGS p.Arg30Trp Uncertain significance Single submitter
- FPGS p.Arg352Gly Uncertain significance Single submitter
- FPGS p.Glu407Gly Uncertain significance Single submitter
- FPGS p.Leu190Phe Uncertain significance Single submitter
- FPGS p.Pro421Leu Uncertain significance Single submitter
- FPGS p.Thr114Met Uncertain significance Single submitter
- FPGS p.Thr416Ile Uncertain significance Single submitter
All FPGS variants
Benign 2
- p.Ile22Val Multiple submitters
- p.Arg466Cys Single submitter
Likely benign 9
- p.Ala19Pro Single submitter
- p.Ala498Thr Single submitter
- p.Ala503= Single submitter
- p.Arg558His Single submitter
- p.Arg95Gln Single submitter
- p.Asp478= Single submitter
- p.Met282Thr Single submitter
- p.Ser497= Single submitter
- p.Ser499Phe Single submitter
Uncertain significance 67
- p.Ala10Ser Single submitter ⚠
- p.Ala15Gly Single submitter ⚠
- p.Ala19Gly Single submitter ⚠
- p.Ala307Ser Single submitter ⚠
- p.Ala395Thr Single submitter ⚠
- p.Ala423Gly Single submitter ⚠
- p.Ala451Thr Single submitter ⚠
- p.Ala4Val Single submitter ⚠
- p.Ala503Thr Single submitter ⚠
- p.Ala512Pro Single submitter ⚠
- p.Ala554Pro Single submitter ⚠
- p.Arg158Cys Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg30Gln Single submitter ⚠
- p.Arg30Trp Single submitter ⚠
- p.Arg332Ser Single submitter ⚠
- p.Arg352Gly Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg5Trp Single submitter ⚠
- p.Arg67His Single submitter ⚠
- p.Arg69Gln Single submitter ⚠
- p.Asn143Ser Single submitter ⚠
- p.Gln145Arg Single submitter ⚠
- p.Gln271Arg Single submitter ⚠
- p.Gln386His Single submitter ⚠
- p.Gln394Arg Single submitter ⚠
- p.Gln397Arg Single submitter ⚠
- p.Gln68Pro Single submitter ⚠
- p.Glu407Gly Single submitter ⚠
- p.Gly404Cys Single submitter ⚠
- p.Gly495Ser Single submitter ⚠
- p.Gly543Ser Single submitter ⚠
- p.His314Asn Single submitter ⚠
- p.His547Gln Single submitter ⚠
- p.His7Tyr Single submitter ⚠
- p.Leu190Phe Single submitter ⚠
- p.Leu336Pro Single submitter ⚠
- p.Leu557His Single submitter ⚠
- p.Leu62Pro Single submitter ⚠
- p.Lys542Glu Single submitter ⚠
- p.Met282Ile Single submitter ⚠
- p.Met351Thr Single submitter ⚠
- p.Met79Thr Single submitter ⚠
- p.Pro131Ser Single submitter ⚠
- p.Pro292Arg Single submitter ⚠
- p.Pro402Ala Single submitter ⚠
- p.Pro402Ser Single submitter ⚠
- p.Pro421Leu Single submitter ⚠
- p.Pro494Leu Single submitter ⚠
- p.Pro504Arg Single submitter ⚠
- p.Pro533Ser Single submitter ⚠
- p.Ser109Thr Single submitter ⚠
- p.Ser223Cys Single submitter ⚠
- p.Ser383Cys Single submitter ⚠
- p.Ser491Asn Single submitter ⚠
- p.Ser511Thr Single submitter ⚠
- p.Thr102Ser Single submitter ⚠
- p.Thr114Met Single submitter ⚠
- p.Thr125Met Single submitter
- p.Thr416Ile Single submitter ⚠
- p.Thr74Pro Single submitter ⚠
- p.Val188Ile Single submitter ⚠
- p.Val201Ala Single submitter ⚠
- p.Val26Gly Single submitter ⚠
- p.Val437Ile Single submitter ⚠