Sugi Variant

Sugi Variant/FPR1

FPR1 — 257 ClinVar variants

All ClinVar germline FPR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 142 flagged for review →

2 Conflicting · 14 Benign · 3 Benign/Likely benign · 83 Likely benign · 155 Uncertain significance

Full FPR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 142

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 108

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All FPR1 variants

Conflicting classifications of pathogenicity 2

Benign 14

  • p.Arg190Trp Multiple submitters gingival disorder
  • p.Asn192= Multiple submitters gingival disorder
  • p.Asn192Lys Multiple submitters gingival disorder
  • p.Glu346Ala Multiple submitters gingival disorder
  • p.Gly274= Multiple submitters gingival disorder
  • p.Ile116= Multiple submitters gingival disorder
  • p.Ile11Thr Multiple submitters gingival disorder
  • p.Leu39= Multiple submitters gingival disorder
  • p.Leu97Met Multiple submitters gingival disorder
  • p.Phe102= Multiple submitters gingival disorder
  • p.Pro182= Multiple submitters gingival disorder
  • p.Thr331= Multiple submitters gingival disorder
  • p.Val101Leu Multiple submitters gingival disorder
  • p.Val59= Multiple submitters gingival disorder

Benign/Likely benign 3

Likely benign 83

  • p.Ala194= Multiple submitters gingival disorder
  • p.Ala248= Multiple submitters gingival disorder
  • p.Asn185Asp Multiple submitters gingival disorder
  • p.Asn44= Multiple submitters gingival disorder
  • p.Gln348= Multiple submitters gingival disorder
  • p.Ile203Val Multiple submitters gingival disorder
  • p.Pro213= Multiple submitters gingival disorder
  • p.Thr9Met Multiple submitters gingival disorder
  • p.Ala20= Single submitter gingival disorder
  • p.Ala218= Single submitter gingival disorder
  • p.Ala318= Single submitter gingival disorder
  • p.Ala323= Single submitter gingival disorder
  • p.Ala349= Single submitter gingival disorder
  • p.Ala68= Single submitter gingival disorder
  • p.Ala86= Single submitter gingival disorder
  • p.Arg123His Single submitter gingival disorder
  • p.Arg205= Single submitter gingival disorder
  • p.Arg241= Single submitter gingival disorder
  • p.Asn10= Single submitter gingival disorder
  • p.Asn135= Single submitter gingival disorder
  • p.Asn185= Single submitter gingival disorder
  • p.Asn297= Single submitter gingival disorder
  • p.Asn4= Single submitter gingival disorder
  • p.Cys126= Single submitter gingival disorder
  • p.Cys176= Single submitter gingival disorder
  • p.Gln306= Single submitter gingival disorder
  • p.Glu346= Single submitter
  • p.Gly111= Single submitter gingival disorder
  • p.Gly14= Single submitter gingival disorder
  • p.Gly148= Single submitter gingival disorder
  • p.Gly209= Single submitter gingival disorder
  • p.Gly232= Single submitter gingival disorder
  • p.Gly52= Single submitter gingival disorder
  • p.His136= Single submitter gingival disorder
  • p.His314= Single submitter gingival disorder
  • p.His57= Single submitter gingival disorder
  • p.Ile147Phe Single submitter gingival disorder
  • p.Ile162= Single submitter gingival disorder
  • p.Ile208= Single submitter gingival disorder
  • p.Ile216= Single submitter gingival disorder
  • p.Ile28= Single submitter gingival disorder
  • p.Ile48= Single submitter gingival disorder
  • p.Ile62= Single submitter gingival disorder
  • p.Leu128= Single submitter gingival disorder
  • p.Leu155= Single submitter gingival disorder
  • p.Leu158= Single submitter gingival disorder
  • p.Leu23= Single submitter gingival disorder
  • p.Leu312= Single submitter gingival disorder
  • p.Leu320= Single submitter gingival disorder
  • p.Leu7= Single submitter gingival disorder
  • p.Leu97= Single submitter gingival disorder
  • p.Lys188= Single submitter gingival disorder
  • p.Lys227= Single submitter
  • p.Lys235= Single submitter gingival disorder
  • p.Phe100= Single submitter gingival disorder
  • p.Phe110= Single submitter gingival disorder
  • p.Phe206= Single submitter gingival disorder
  • p.Phe291= Single submitter gingival disorder
  • p.Phe292= Single submitter gingival disorder
  • p.Phe93= Single submitter gingival disorder
  • p.Pro130= Single submitter gingival disorder
  • p.Pro149= Single submitter gingival disorder
  • p.Pro317= Single submitter gingival disorder
  • p.Ser181= Single submitter gingival disorder
  • p.Ser319= Single submitter gingival disorder
  • p.Ser5= Single submitter gingival disorder
  • p.Ser63= Single submitter gingival disorder
  • p.Ser6Phe Single submitter gingival disorder ⚠
  • p.Thr138= Single submitter gingival disorder
  • p.Thr171= Single submitter gingival disorder
  • p.Thr173= Single submitter gingival disorder
  • p.Thr199= Single submitter gingival disorder
  • p.Thr286= Single submitter gingival disorder
  • p.Thr325= Single submitter gingival disorder
  • p.Thr336= Single submitter gingival disorder
  • p.Thr9= Single submitter gingival disorder
  • p.Tyr221= Single submitter gingival disorder
  • p.Val113= Single submitter gingival disorder
  • p.Val127= Single submitter gingival disorder
  • p.Val151= Single submitter gingival disorder
  • p.Val242= Single submitter gingival disorder
  • p.Val246= Single submitter gingival disorder
  • p.Val50= Single submitter gingival disorder

Uncertain significance 155