FRS2 — 65 ClinVar variants
All ClinVar germline FRS2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
1 Likely benign · 64 Uncertain significance
Full FRS2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 45
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FRS2 p.Ala218Val Uncertain significance Single submitter
- FRS2 p.Ala223Thr Uncertain significance Single submitter
- FRS2 p.Arg134Gln Uncertain significance Single submitter
- FRS2 p.Arg206Gln Uncertain significance Single submitter
- FRS2 p.Arg209Cys Uncertain significance Single submitter
- FRS2 p.Arg209His Uncertain significance Single submitter
- FRS2 p.Arg209Leu Uncertain significance Single submitter
- FRS2 p.Arg219Lys Uncertain significance Single submitter
- FRS2 p.Arg273Lys Uncertain significance Single submitter
- FRS2 p.Arg295Gln Uncertain significance Single submitter
- FRS2 p.Arg324His Uncertain significance Single submitter
- FRS2 p.Arg362Cys Uncertain significance Single submitter
- FRS2 p.Arg411Gly Uncertain significance Single submitter
- FRS2 p.Arg412Cys Uncertain significance Single submitter
- FRS2 p.Arg426Cys Uncertain significance Single submitter
- FRS2 p.Arg426His Uncertain significance Single submitter
- FRS2 p.Arg50Cys Uncertain significance Single submitter
- FRS2 p.Arg50His Uncertain significance Single submitter
- FRS2 p.Asn484Asp Uncertain significance Single submitter
- FRS2 p.Asp332Tyr Uncertain significance Single submitter
- FRS2 p.Gln144Arg Uncertain significance Single submitter
- FRS2 p.Gln270His Uncertain significance Single submitter
- FRS2 p.Gln275Arg Uncertain significance Single submitter
- FRS2 p.Glu230Lys Uncertain significance Single submitter
- FRS2 p.Gly201Asp Uncertain significance Single submitter
- FRS2 p.Ile336Phe Uncertain significance Single submitter
- FRS2 p.Ile336Val Uncertain significance Single submitter
- FRS2 p.Ile437Val Uncertain significance Single submitter
- FRS2 p.Leu243Ile Uncertain significance Single submitter
- FRS2 p.Lys229Glu Uncertain significance Single submitter
- FRS2 p.Met389Val Uncertain significance Single submitter
- FRS2 p.Pro246Thr Uncertain significance Single submitter
- FRS2 p.Pro388Ala Uncertain significance Single submitter
- FRS2 p.Pro388Gln Uncertain significance Single submitter
- FRS2 p.Ser226Cys Uncertain significance Single submitter
- FRS2 p.Ser331Leu Uncertain significance Single submitter
- FRS2 p.Thr137Ala Uncertain significance Single submitter
- FRS2 p.Thr183Ala Uncertain significance Single submitter
- FRS2 p.Thr330Asn Uncertain significance Single submitter
- FRS2 p.Thr344Ala Uncertain significance Single submitter
- FRS2 p.Thr458Ala Uncertain significance Single submitter
- FRS2 p.Tyr153Phe Uncertain significance Single submitter
- FRS2 p.Val214Ile Uncertain significance Single submitter
- FRS2 p.Val305Met Uncertain significance Single submitter
- FRS2 p.Val473Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- FRS2 p.Ala92Asp Uncertain significance Single submitter
- FRS2 p.Arg52His Uncertain significance Single submitter
- FRS2 p.Arg93His Uncertain significance Single submitter
- FRS2 p.Cys7Tyr Uncertain significance Single submitter
- FRS2 p.Glu96Gln Uncertain significance Single submitter
- FRS2 p.Met482Val Uncertain significance Single submitter
- FRS2 p.Phe422Leu Uncertain significance Single submitter
- FRS2 p.Pro176Arg Uncertain significance Single submitter
- FRS2 p.Pro456Ser Uncertain significance Single submitter
- FRS2 p.Ser155Leu Uncertain significance Single submitter
- FRS2 p.Ser503Asn Uncertain significance Single submitter
- FRS2 p.Thr132Ala Uncertain significance Single submitter
- FRS2 p.Thr376Ile Uncertain significance Single submitter
- FRS2 p.Thr455Met Uncertain significance Single submitter
- FRS2 p.Trp286Arg Uncertain significance Single submitter
- FRS2 p.Trp359Leu Uncertain significance Single submitter
All FRS2 variants
Likely benign 1
- p.Ser226Asn Single submitter
Uncertain significance 64
- c.576+1G>T Single submitter
- p.Ala218Val Single submitter ⚠
- p.Ala223Thr Single submitter ⚠
- p.Ala92Asp Single submitter ⚠
- p.Arg134Gln Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg209Cys Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg209Leu Single submitter ⚠
- p.Arg219Lys Single submitter ⚠
- p.Arg273Lys Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg324His Single submitter ⚠
- p.Arg362Cys Single submitter ⚠
- p.Arg411Gly Single submitter ⚠
- p.Arg412Cys Single submitter ⚠
- p.Arg426Cys Single submitter ⚠
- p.Arg426His Single submitter ⚠
- p.Arg50Cys Single submitter ⚠
- p.Arg50His Single submitter ⚠
- p.Arg52His Single submitter ⚠
- p.Arg93His Single submitter ⚠
- p.Asn484Asp Single submitter ⚠
- p.Asp332Tyr Single submitter ⚠
- p.Cys7Tyr Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Gln270His Single submitter ⚠
- p.Gln275Arg Single submitter ⚠
- p.Glu230Lys Single submitter ⚠
- p.Glu96Gln Single submitter ⚠
- p.Gly201Asp Single submitter ⚠
- p.Ile336Phe Single submitter ⚠
- p.Ile336Val Single submitter ⚠
- p.Ile437Val Single submitter ⚠
- p.Leu243Ile Single submitter ⚠
- p.Lys229Glu Single submitter ⚠
- p.Met389Val Single submitter ⚠
- p.Met482Val Single submitter ⚠
- p.Phe422Leu Single submitter ⚠
- p.Pro176Arg Single submitter ⚠
- p.Pro246Thr Single submitter ⚠
- p.Pro388Ala Single submitter ⚠
- p.Pro388Gln Single submitter ⚠
- p.Pro456Ser Single submitter ⚠
- p.Ser109Gly Single submitter
- p.Ser155Leu Single submitter ⚠
- p.Ser226Cys Single submitter ⚠
- p.Ser331Leu Single submitter ⚠
- p.Ser503Asn Single submitter ⚠
- p.Thr132Ala Single submitter ⚠
- p.Thr137Ala Single submitter ⚠
- p.Thr183Ala Single submitter ⚠
- p.Thr330Asn Single submitter ⚠
- p.Thr344Ala Single submitter ⚠
- p.Thr376Ile Single submitter ⚠
- p.Thr455Met Single submitter ⚠
- p.Thr458Ala Single submitter ⚠
- p.Trp286Arg Single submitter ⚠
- p.Trp359Leu Single submitter ⚠
- p.Tyr153Phe Single submitter ⚠
- p.Val214Ile Single submitter ⚠
- p.Val305Met Single submitter ⚠
- p.Val398fs Single submitter
- p.Val473Met Single submitter ⚠