FSCN1 — 68 ClinVar variants
All ClinVar germline FSCN1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
3 Likely benign · 65 Uncertain significance
Full FSCN1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 46
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FSCN1 p.Thr316Met Uncertain significance Multiple submitters
- FSCN1 p.Ala107Thr Uncertain significance Single submitter
- FSCN1 p.Ala191Ser Uncertain significance Single submitter
- FSCN1 p.Ala267Gly Uncertain significance Single submitter
- FSCN1 p.Ala268Thr Uncertain significance Single submitter
- FSCN1 p.Ala332Val Uncertain significance Single submitter
- FSCN1 p.Ala422Thr Uncertain significance Single submitter
- FSCN1 p.Ala440Thr Uncertain significance Single submitter
- FSCN1 p.Ala488Thr Uncertain significance Single submitter
- FSCN1 p.Ala71Glu Uncertain significance Single submitter
- FSCN1 p.Ala72Val Uncertain significance Single submitter
- FSCN1 p.Arg344Cys Uncertain significance Single submitter
- FSCN1 p.Asp446Asn Uncertain significance Single submitter
- FSCN1 p.Asp450Glu Uncertain significance Single submitter
- FSCN1 p.Asp457Gly Uncertain significance Single submitter
- FSCN1 p.Asp473Asn Uncertain significance Single submitter
- FSCN1 p.Gln104Arg Uncertain significance Single submitter
- FSCN1 p.Gln189Arg Uncertain significance Single submitter
- FSCN1 p.Gln258His Uncertain significance Single submitter
- FSCN1 p.Glu252Asp Uncertain significance Single submitter
- FSCN1 p.Glu270Lys Uncertain significance Single submitter
- FSCN1 p.Glu417Asp Uncertain significance Single submitter
- FSCN1 p.Glu417Gln Uncertain significance Single submitter
- FSCN1 p.Gly249Ser Uncertain significance Single submitter
- FSCN1 p.Gly467Arg Uncertain significance Single submitter
- FSCN1 p.Gly56Arg Uncertain significance Single submitter
- FSCN1 p.His108Gln Uncertain significance Single submitter
- FSCN1 p.His193Tyr Uncertain significance Single submitter
- FSCN1 p.His392Arg Uncertain significance Single submitter
- FSCN1 p.His65Pro Uncertain significance Single submitter
- FSCN1 p.Ile144Val Uncertain significance Single submitter
- FSCN1 p.Ile395Val Uncertain significance Single submitter
- FSCN1 p.Lys41Asn Uncertain significance Single submitter
- FSCN1 p.Met138Thr Uncertain significance Single submitter
- FSCN1 p.Phe451Tyr Uncertain significance Single submitter
- FSCN1 p.Phe451Val Uncertain significance Single submitter
- FSCN1 p.Pro208Ser Uncertain significance Single submitter
- FSCN1 p.Ser325Ala Uncertain significance Single submitter
- FSCN1 p.Ser443Cys Uncertain significance Single submitter
- FSCN1 p.Thr311Ala Uncertain significance Single submitter
- FSCN1 p.Thr318Met Uncertain significance Single submitter
- FSCN1 p.Val134Leu Uncertain significance Single submitter
- FSCN1 p.Val188Met Uncertain significance Single submitter
- FSCN1 p.Val248Leu Uncertain significance Single submitter
- FSCN1 p.Val400Ile Uncertain significance Single submitter
- FSCN1 p.Val413Leu Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- FSCN1 p.Ala349Ser Uncertain significance Single submitter
- FSCN1 p.Arg398Cys Uncertain significance Single submitter
- FSCN1 p.Arg398His Uncertain significance Single submitter
- FSCN1 p.Arg468Cys Uncertain significance Single submitter
- FSCN1 p.Asn269Lys Uncertain significance Single submitter
- FSCN1 p.Glu339Lys Uncertain significance Single submitter
- FSCN1 p.Gly466Cys Uncertain significance Single submitter
- FSCN1 p.His96Tyr Uncertain significance Single submitter
- FSCN1 p.Ser39Asn Uncertain significance Single submitter
- FSCN1 p.Thr356Asn Uncertain significance Single submitter
- FSCN1 p.Thr429Lys Uncertain significance Single submitter
- FSCN1 p.Thr447Ile Uncertain significance Single submitter
- FSCN1 p.Val367Met Uncertain significance Single submitter
All FSCN1 variants
Likely benign 3
- p.Ala164= Single submitter
- p.Pro87Ala Single submitter
- p.Thr434Met Single submitter
Uncertain significance 65
- p.Thr316Met Multiple submitters ⚠
- p.Ala107Thr Single submitter ⚠
- p.Ala191Ser Single submitter ⚠
- p.Ala267Gly Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala332Val Single submitter ⚠
- p.Ala349Ser Single submitter ⚠
- p.Ala422Thr Single submitter ⚠
- p.Ala440Thr Single submitter ⚠
- p.Ala488Thr Single submitter ⚠
- p.Ala71Glu Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Arg308His Single submitter
- p.Arg344Cys Single submitter ⚠
- p.Arg389His Single submitter
- p.Arg398Cys Single submitter ⚠
- p.Arg398His Single submitter ⚠
- p.Arg468Cys Single submitter ⚠
- p.Asn269Lys Single submitter ⚠
- p.Asp446Asn Single submitter ⚠
- p.Asp450Glu Single submitter ⚠
- p.Asp450Val Single submitter
- p.Asp457Gly Single submitter ⚠
- p.Asp457His Single submitter
- p.Asp473Asn Single submitter ⚠
- p.Gln104Arg Single submitter ⚠
- p.Gln189Arg Single submitter ⚠
- p.Gln258His Single submitter ⚠
- p.Glu252Asp Single submitter ⚠
- p.Glu270Lys Single submitter ⚠
- p.Glu339Lys Single submitter ⚠
- p.Glu417Asp Single submitter ⚠
- p.Glu417Gln Single submitter ⚠
- p.Gly219Ser Single submitter
- p.Gly249Ser Single submitter ⚠
- p.Gly466Cys Single submitter ⚠
- p.Gly467Arg Single submitter ⚠
- p.Gly56Arg Single submitter ⚠
- p.His108Gln Single submitter ⚠
- p.His193Tyr Single submitter ⚠
- p.His392Arg Single submitter ⚠
- p.His65Pro Single submitter ⚠
- p.His96Tyr Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Ile17del Single submitter
- p.Ile395Val Single submitter ⚠
- p.Lys41Asn Single submitter ⚠
- p.Met138Thr Single submitter ⚠
- p.Phe451Tyr Single submitter ⚠
- p.Phe451Val Single submitter ⚠
- p.Pro208Ser Single submitter ⚠
- p.Ser325Ala Single submitter ⚠
- p.Ser39Asn Single submitter ⚠
- p.Ser443Cys Single submitter ⚠
- p.Thr311Ala Single submitter ⚠
- p.Thr318Met Single submitter ⚠
- p.Thr356Asn Single submitter ⚠
- p.Thr429Lys Single submitter ⚠
- p.Thr447Ile Single submitter ⚠
- p.Val134Leu Single submitter ⚠
- p.Val188Met Single submitter ⚠
- p.Val248Leu Single submitter ⚠
- p.Val367Met Single submitter ⚠
- p.Val400Ile Single submitter ⚠
- p.Val413Leu Single submitter ⚠