FUBP1 — 53 ClinVar variants
All ClinVar germline FUBP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Benign · 50 Uncertain significance
Full FUBP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FUBP1 p.Ala174Val Uncertain significance Single submitter
- FUBP1 p.Ala408Thr Uncertain significance Single submitter
- FUBP1 p.Ala506Val Uncertain significance Single submitter
- FUBP1 p.Ala542Thr Uncertain significance Single submitter
- FUBP1 p.Ala557Val Uncertain significance Single submitter
- FUBP1 p.Ala599Ser Uncertain significance Single submitter
- FUBP1 p.Arg256Cys Uncertain significance Single submitter
- FUBP1 p.Arg256His Uncertain significance Single submitter
- FUBP1 p.Asn303Ser Uncertain significance Single submitter
- FUBP1 p.Asn573Ser Uncertain significance Single submitter
- FUBP1 p.Cys148Tyr Uncertain significance Single submitter
- FUBP1 p.Gln166His Uncertain significance Single submitter
- FUBP1 p.Gln377Glu Uncertain significance Single submitter
- FUBP1 p.Gln636Lys Uncertain significance Single submitter
- FUBP1 p.Gly225Arg Uncertain significance Single submitter
- FUBP1 p.Gly260Ser Uncertain significance Single submitter
- FUBP1 p.Gly431Ser Uncertain significance Single submitter
- FUBP1 p.Gly448Cys Uncertain significance Single submitter
- FUBP1 p.Gly492Glu Uncertain significance Single submitter
- FUBP1 p.His179Arg Uncertain significance Single submitter
- FUBP1 p.Ile278Met Uncertain significance Single submitter
- FUBP1 p.Ile278Val Uncertain significance Single submitter
- FUBP1 p.Ile429Val Uncertain significance Single submitter
- FUBP1 p.Ile443Val Uncertain significance Single submitter
- FUBP1 p.Leu376Pro Uncertain significance Single submitter
- FUBP1 p.Leu454Ser Uncertain significance Single submitter
- FUBP1 p.Met481Thr Uncertain significance Single submitter
- FUBP1 p.Met481Val Uncertain significance Single submitter
- FUBP1 p.Pro183Leu Uncertain significance Single submitter
- FUBP1 p.Pro372Gln Uncertain significance Single submitter
- FUBP1 p.Ser52Leu Uncertain significance Single submitter
- FUBP1 p.Val244Phe Uncertain significance Single submitter
Predictors split 14
The independent predictors disagree with each other — read with care.
- FUBP1 p.Arg214Gln Uncertain significance Single submitter
- FUBP1 p.Asn485Asp Uncertain significance Single submitter
- FUBP1 p.Gln579Arg Uncertain significance Single submitter
- FUBP1 p.Glu617Asp Uncertain significance Single submitter
- FUBP1 p.Gly59Cys Uncertain significance Single submitter
- FUBP1 p.Gly70Glu Uncertain significance Single submitter
- FUBP1 p.Ile410Met Uncertain significance Single submitter
- FUBP1 p.Ile429Phe Uncertain significance Single submitter
- FUBP1 p.Met111Val Uncertain significance Single submitter
- FUBP1 p.Phe379Ser Uncertain significance Single submitter
- FUBP1 p.Phe381Cys Uncertain significance Single submitter
- FUBP1 p.Pro477Ser Uncertain significance Single submitter
- FUBP1 p.Thr601Ile Uncertain significance Single submitter
- FUBP1 p.Tyr4Cys Uncertain significance Single submitter
All FUBP1 variants
Benign 3
- c.1042-8C>G Multiple submitters
- p.Gly18= Multiple submitters
- p.Ser401= Multiple submitters
Uncertain significance 50
- p.Ala174Val Single submitter ⚠
- p.Ala408Thr Single submitter ⚠
- p.Ala506Val Single submitter ⚠
- p.Ala542Thr Single submitter ⚠
- p.Ala557Val Single submitter ⚠
- p.Ala599Ser Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg256Cys Single submitter ⚠
- p.Arg256His Single submitter ⚠
- p.Asn303Ser Single submitter ⚠
- p.Asn485Asp Single submitter ⚠
- p.Asn573Ser Single submitter ⚠
- p.Cys148Tyr Single submitter ⚠
- p.Gln166His Single submitter ⚠
- p.Gln377Glu Single submitter ⚠
- p.Gln579Arg Single submitter ⚠
- p.Gln636Lys Single submitter ⚠
- p.Glu617Asp Single submitter ⚠
- p.Gly225Arg Single submitter ⚠
- p.Gly260Ser Single submitter ⚠
- p.Gly431Ser Single submitter ⚠
- p.Gly448Cys Single submitter ⚠
- p.Gly492Glu Single submitter ⚠
- p.Gly59Cys Single submitter ⚠
- p.Gly70Glu Single submitter ⚠
- p.His179Arg Single submitter ⚠
- p.Ile278Met Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Ile410Met Single submitter ⚠
- p.Ile429Phe Single submitter ⚠
- p.Ile429Val Single submitter ⚠
- p.Ile443Val Single submitter ⚠
- p.Leu376Pro Single submitter ⚠
- p.Leu454Ser Single submitter ⚠
- p.Met111Val Single submitter ⚠
- p.Met481Thr Single submitter ⚠
- p.Met481Val Single submitter ⚠
- p.Phe379Ser Single submitter ⚠
- p.Phe381Cys Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro372Gln Single submitter ⚠
- p.Pro450Leu Single submitter
- p.Pro477Ser Single submitter ⚠
- p.Pro494Arg Single submitter
- p.Ser52Leu Single submitter ⚠
- p.Thr601Ile Single submitter ⚠
- p.Tyr4Cys Single submitter ⚠
- p.Val112fs Single submitter
- p.Val244Phe Single submitter ⚠
- p.Trp537Ter No assertion criteria breast ductal adenocarcinoma