FUBP3 — 68 ClinVar variants
All ClinVar germline FUBP3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
4 Likely benign · 64 Uncertain significance
Full FUBP3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 48
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FUBP3 p.Ala314Val Uncertain significance Single submitter
- FUBP3 p.Ala435Thr Uncertain significance Single submitter
- FUBP3 p.Ala435Val Uncertain significance Single submitter
- FUBP3 p.Arg102Trp Uncertain significance Single submitter
- FUBP3 p.Arg149Gln Uncertain significance Single submitter
- FUBP3 p.Arg191Trp Uncertain significance Single submitter
- FUBP3 p.Arg213Cys Uncertain significance Single submitter
- FUBP3 p.Arg244Cys Uncertain significance Single submitter
- FUBP3 p.Arg244His Uncertain significance Single submitter
- FUBP3 p.Arg456Lys Uncertain significance Single submitter
- FUBP3 p.Asn401Ser Uncertain significance Single submitter
- FUBP3 p.Asp217Gly Uncertain significance Single submitter
- FUBP3 p.Asp217Val Uncertain significance Single submitter
- FUBP3 p.Asp345Glu Uncertain significance Single submitter
- FUBP3 p.Asp399Asn Uncertain significance Single submitter
- FUBP3 p.Gln288His Uncertain significance Single submitter
- FUBP3 p.Gln302His Uncertain significance Single submitter
- FUBP3 p.Gln419Leu Uncertain significance Single submitter
- FUBP3 p.Gly119Arg Uncertain significance Single submitter
- FUBP3 p.Gly175Val Uncertain significance Single submitter
- FUBP3 p.Gly254Ser Uncertain significance Single submitter
- FUBP3 p.Gly284Cys Uncertain significance Single submitter
- FUBP3 p.Gly329Ser Uncertain significance Single submitter
- FUBP3 p.Gly373Ala Uncertain significance Single submitter
- FUBP3 p.Gly374Asp Uncertain significance Single submitter
- FUBP3 p.Gly431Arg Uncertain significance Single submitter
- FUBP3 p.His568Arg Uncertain significance Single submitter
- FUBP3 p.Ile134Val Uncertain significance Single submitter
- FUBP3 p.Ile357Val Uncertain significance Single submitter
- FUBP3 p.Ile36Val Uncertain significance Single submitter
- FUBP3 p.Met304Val Uncertain significance Single submitter
- FUBP3 p.Met464Val Uncertain significance Single submitter
- FUBP3 p.Met545Val Uncertain significance Single submitter
- FUBP3 p.Pro307Leu Uncertain significance Single submitter
- FUBP3 p.Pro351Ala Uncertain significance Single submitter
- FUBP3 p.Pro44Thr Uncertain significance Single submitter
- FUBP3 p.Pro503Ser Uncertain significance Single submitter
- FUBP3 p.Pro535Ser Uncertain significance Single submitter
- FUBP3 p.Ser442Gly Uncertain significance Single submitter
- FUBP3 p.Ser49Thr Uncertain significance Single submitter
- FUBP3 p.Thr428Ala Uncertain significance Single submitter
- FUBP3 p.Thr491Ile Uncertain significance Single submitter
- FUBP3 p.Thr76Met Uncertain significance Single submitter
- FUBP3 p.Tyr543Cys Uncertain significance Single submitter
- FUBP3 p.Val20Met Uncertain significance Single submitter
- FUBP3 p.Val348Met Uncertain significance Single submitter
- FUBP3 p.Val410Leu Uncertain significance Single submitter
- FUBP3 p.Val55Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- FUBP3 p.Ala556Thr Uncertain significance Single submitter
- FUBP3 p.Arg241Trp Uncertain significance Single submitter
- FUBP3 p.Arg341His Uncertain significance Single submitter
- FUBP3 p.Arg343Cys Uncertain significance Single submitter
- FUBP3 p.Asp21Asn Uncertain significance Single submitter
- FUBP3 p.Phe461Leu Uncertain significance Single submitter
- FUBP3 p.Pro291Ser Uncertain significance Single submitter
- FUBP3 p.Pro306Leu Uncertain significance Single submitter
- FUBP3 p.Pro395Ser Uncertain significance Single submitter
- FUBP3 p.Pro396Ser Uncertain significance Single submitter
- FUBP3 p.Ser439Arg Uncertain significance Single submitter
- FUBP3 p.Thr79Met Uncertain significance Single submitter
All FUBP3 variants
Likely benign 4
- p.Ala335Val Single submitter
- p.Gly245Ser Single submitter
- p.Ile158Val Single submitter
- p.Val354Ile Single submitter
Uncertain significance 64
- p.Ala314Val Single submitter ⚠
- p.Ala435Thr Single submitter ⚠
- p.Ala435Val Single submitter ⚠
- p.Ala556Thr Single submitter ⚠
- p.Arg102Trp Single submitter ⚠
- p.Arg149Gln Single submitter ⚠
- p.Arg191Trp Single submitter ⚠
- p.Arg213Cys Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg244Cys Single submitter ⚠
- p.Arg244His Single submitter ⚠
- p.Arg339Thr Single submitter
- p.Arg341His Single submitter ⚠
- p.Arg343Cys Single submitter ⚠
- p.Arg456Lys Single submitter ⚠
- p.Asn401Ser Single submitter ⚠
- p.Asp217Gly Single submitter ⚠
- p.Asp217Val Single submitter ⚠
- p.Asp21Asn Single submitter ⚠
- p.Asp345Glu Single submitter ⚠
- p.Asp345Tyr Single submitter
- p.Asp399Asn Single submitter ⚠
- p.Gln288His Single submitter ⚠
- p.Gln302His Single submitter ⚠
- p.Gln419Leu Single submitter ⚠
- p.Gly119Arg Single submitter ⚠
- p.Gly175Val Single submitter ⚠
- p.Gly254Ser Single submitter ⚠
- p.Gly284Cys Single submitter ⚠
- p.Gly329Ser Single submitter ⚠
- p.Gly373Ala Single submitter ⚠
- p.Gly374Asp Single submitter ⚠
- p.Gly431Arg Single submitter ⚠
- p.His568Arg Single submitter ⚠
- p.Ile134Val Single submitter ⚠
- p.Ile357Val Single submitter ⚠
- p.Ile36Val Single submitter ⚠
- p.Lys220Gln Single submitter
- p.Met304Val Single submitter ⚠
- p.Met464Val Single submitter ⚠
- p.Met545Val Single submitter ⚠
- p.Phe461Leu Single submitter ⚠
- p.Pro291Ser Single submitter ⚠
- p.Pro306Leu Single submitter ⚠
- p.Pro307Leu Single submitter ⚠
- p.Pro351Ala Single submitter ⚠
- p.Pro395Ser Single submitter ⚠
- p.Pro396Ser Single submitter ⚠
- p.Pro44Thr Single submitter ⚠
- p.Pro503Ser Single submitter ⚠
- p.Pro535Ser Single submitter ⚠
- p.Ser439Arg Single submitter ⚠
- p.Ser442Gly Single submitter ⚠
- p.Ser49Thr Single submitter ⚠
- p.Thr428Ala Single submitter ⚠
- p.Thr491Ile Single submitter ⚠
- p.Thr76Met Single submitter ⚠
- p.Thr79Met Single submitter ⚠
- p.Tyr543Cys Single submitter ⚠
- p.Tyr543Ser Single submitter
- p.Val20Met Single submitter ⚠
- p.Val348Met Single submitter ⚠
- p.Val410Leu Single submitter ⚠
- p.Val55Ile Single submitter ⚠