FURIN — 107 ClinVar variants
All ClinVar germline FURIN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 93 flagged for review →
1 Benign · 6 Likely benign · 100 Uncertain significance
Full FURIN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 93
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FURIN p.Ala101Pro Uncertain significance Single submitter
- FURIN p.Ala139Val Uncertain significance Single submitter
- FURIN p.Ala234Val Uncertain significance Single submitter
- FURIN p.Ala270Ser Uncertain significance Single submitter
- FURIN p.Ala273Thr Uncertain significance Single submitter
- FURIN p.Ala412Ser Uncertain significance Single submitter
- FURIN p.Ala436Val Uncertain significance Single submitter
- FURIN p.Ala473Thr Uncertain significance Single submitter
- FURIN p.Ala502Val Uncertain significance Single submitter
- FURIN p.Ala525Thr Uncertain significance Single submitter
- FURIN p.Ala638Val Uncertain significance Single submitter
- FURIN p.Ala666Gly Uncertain significance Single submitter
- FURIN p.Ala700Val Uncertain significance Single submitter
- FURIN p.Ala706Thr Uncertain significance Single submitter
- FURIN p.Ala706Val Uncertain significance Single submitter
- FURIN p.Ala723Thr Uncertain significance Single submitter
- FURIN p.Ala793Thr Uncertain significance Single submitter
- FURIN p.Arg276Cys Uncertain significance Single submitter
- FURIN p.Arg276His Uncertain significance Single submitter
- FURIN p.Arg497Cys Uncertain significance Single submitter
- FURIN p.Arg50Trp Uncertain significance Single submitter
- FURIN p.Arg512Cys Uncertain significance Single submitter
- FURIN p.Arg512Pro Uncertain significance Single submitter
- FURIN p.Arg512Ser Uncertain significance Single submitter
- FURIN p.Arg677Gln Uncertain significance Single submitter
- FURIN p.Arg693Gln Uncertain significance Single submitter
- FURIN p.Arg705Trp Uncertain significance Single submitter
- FURIN p.Arg739Cys Uncertain significance Single submitter
- FURIN p.Arg745Trp Uncertain significance Single submitter
- FURIN p.Arg754Cys Uncertain significance Single submitter
- FURIN p.Arg754His Uncertain significance Single submitter
- FURIN p.Arg781Gln Uncertain significance Single submitter
- FURIN p.Arg781Trp Uncertain significance Single submitter
- FURIN p.Arg81His Uncertain significance Single submitter
- FURIN p.Asn207Ser Uncertain significance Single submitter
- FURIN p.Asn407Ser Uncertain significance Single submitter
- FURIN p.Asp453Asn Uncertain significance Single submitter
- FURIN p.Cys662Arg Uncertain significance Single submitter
- FURIN p.Gln178Leu Uncertain significance Single submitter
- FURIN p.Gln791His Uncertain significance Single submitter
- FURIN p.Glu112Asp Uncertain significance Single submitter
- FURIN p.Glu552Gln Uncertain significance Single submitter
- FURIN p.Glu556Lys Uncertain significance Single submitter
- FURIN p.Glu630Lys Uncertain significance Single submitter
- FURIN p.Gly307Ser Uncertain significance Single submitter
- FURIN p.Gly719Ser Uncertain significance Single submitter
- FURIN p.His145Tyr Uncertain significance Single submitter
- FURIN p.His626Leu Uncertain significance Single submitter
- FURIN p.Ile377Thr Uncertain significance Single submitter
- FURIN p.Ile503Val Uncertain significance Single submitter
- FURIN p.Leu380Val Uncertain significance Single submitter
- FURIN p.Leu475Pro Uncertain significance Single submitter
- FURIN p.Leu570Phe Uncertain significance Single submitter
- FURIN p.Leu578Gln Uncertain significance Single submitter
- FURIN p.Leu756Phe Uncertain significance Single submitter
- FURIN p.Met534Ile Uncertain significance Single submitter
- FURIN p.Pro478Ser Uncertain significance Single submitter
- FURIN p.Pro508Ala Uncertain significance Single submitter
- FURIN p.Pro520Thr Uncertain significance Single submitter
- FURIN p.Pro543Ser Uncertain significance Single submitter
- FURIN p.Pro686Leu Uncertain significance Single submitter
- FURIN p.Pro692Leu Uncertain significance Single submitter
- FURIN p.Pro772Leu Uncertain significance Single submitter
- FURIN p.Ser311Ile Uncertain significance Single submitter
- FURIN p.Ser507Cys Uncertain significance Single submitter
- FURIN p.Thr314Met Uncertain significance Single submitter
- FURIN p.Thr336Ile Uncertain significance Single submitter
- FURIN p.Thr564Ala Uncertain significance Single submitter
- FURIN p.Thr625Met Uncertain significance Single submitter
- FURIN p.Thr73Met Uncertain significance Single submitter
- FURIN p.Val175Ile Uncertain significance Single submitter
- FURIN p.Val210Ala Uncertain significance Single submitter
- FURIN p.Val398Leu Uncertain significance Single submitter
- FURIN p.Val726Leu Uncertain significance Single submitter
Predictors split 19
The independent predictors disagree with each other — read with care.
- FURIN p.Ala136Val Uncertain significance Single submitter
- FURIN p.Ala532Thr Uncertain significance Single submitter
- FURIN p.Arg220Leu Uncertain significance Single submitter
- FURIN p.Arg448Trp Uncertain significance Single submitter
- FURIN p.Arg490Trp Uncertain significance Single submitter
- FURIN p.Arg512His Uncertain significance Single submitter
- FURIN p.Arg81Cys Likely benign Single submitter
- FURIN p.Arg86Trp Uncertain significance Single submitter
- FURIN p.Asn207His Uncertain significance Single submitter
- FURIN p.Gly40Glu Uncertain significance Single submitter
- FURIN p.Gly719Arg Uncertain significance Single submitter
- FURIN p.Ile551Thr Uncertain significance Single submitter
- FURIN p.Leu493Val Uncertain significance Single submitter
- FURIN p.Lys402Glu Uncertain significance Single submitter
- FURIN p.Phe528Tyr Uncertain significance Single submitter
- FURIN p.Pro169Thr Uncertain significance Single submitter
- FURIN p.Pro403Ser Uncertain significance Single submitter
- FURIN p.Pro458Leu Uncertain significance Single submitter
- FURIN p.Thr536Ser Uncertain significance Single submitter
All FURIN variants
Benign 1
- c.-159-2262C>A Single submitter
Likely benign 6
- c.1377-6G>T Single submitter
- p.Ala642Thr Single submitter
- p.Arg81Cys Single submitter ⚠
- p.Asp153= Single submitter
- p.Glu672= Single submitter
- p.His145= Single submitter
Uncertain significance 100
- c.578+1dup Single submitter
- p.Ala101Pro Single submitter ⚠
- p.Ala136Val Single submitter ⚠
- p.Ala139Val Single submitter ⚠
- p.Ala234Val Single submitter ⚠
- p.Ala270Ser Single submitter ⚠
- p.Ala273Thr Single submitter ⚠
- p.Ala412Ser Single submitter ⚠
- p.Ala436Val Single submitter ⚠
- p.Ala473Thr Single submitter ⚠
- p.Ala49Ser Single submitter
- p.Ala502Val Single submitter ⚠
- p.Ala525Thr Single submitter ⚠
- p.Ala532Thr Single submitter ⚠
- p.Ala638Val Single submitter ⚠
- p.Ala666Gly Single submitter ⚠
- p.Ala700Val Single submitter ⚠
- p.Ala706Thr Single submitter ⚠
- p.Ala706Val Single submitter ⚠
- p.Ala723Thr Single submitter ⚠
- p.Ala793Thr Single submitter ⚠
- p.Arg220Leu Single submitter ⚠
- p.Arg276Cys Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg448Trp Single submitter ⚠
- p.Arg490Trp Single submitter ⚠
- p.Arg497Cys Single submitter ⚠
- p.Arg50Trp Single submitter ⚠
- p.Arg512Cys Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Arg512Pro Single submitter ⚠
- p.Arg512Ser Single submitter ⚠
- p.Arg677Gln Single submitter ⚠
- p.Arg693Gln Single submitter ⚠
- p.Arg705Trp Single submitter ⚠
- p.Arg739Cys Single submitter ⚠
- p.Arg745Trp Single submitter ⚠
- p.Arg754Cys Single submitter ⚠
- p.Arg754His Single submitter ⚠
- p.Arg781Gln Single submitter ⚠
- p.Arg781Trp Single submitter ⚠
- p.Arg81His Single submitter ⚠
- p.Arg86Trp Single submitter ⚠
- p.Asn207His Single submitter ⚠
- p.Asn207Ser Single submitter ⚠
- p.Asn407Ser Single submitter ⚠
- p.Asp453Asn Single submitter ⚠
- p.Cys662Arg Single submitter ⚠
- p.Gln178Leu Single submitter ⚠
- p.Gln737Arg Single submitter
- p.Gln791His Single submitter ⚠
- p.Glu112Asp Single submitter ⚠
- p.Glu552Gln Single submitter ⚠
- p.Glu556Lys Single submitter ⚠
- p.Glu630Lys Single submitter ⚠
- p.Gly283Val Single submitter
- p.Gly307Ser Single submitter ⚠
- p.Gly40Glu Single submitter ⚠
- p.Gly719Arg Single submitter ⚠
- p.Gly719Ser Single submitter ⚠
- p.His145Tyr Single submitter ⚠
- p.His626Leu Single submitter ⚠
- p.Ile377Thr Single submitter ⚠
- p.Ile503Val Single submitter ⚠
- p.Ile551Thr Single submitter ⚠
- p.Leu380Val Single submitter ⚠
- p.Leu475Pro Single submitter ⚠
- p.Leu493Val Single submitter ⚠
- p.Leu570Phe Single submitter ⚠
- p.Leu578Gln Single submitter ⚠
- p.Leu756Phe Single submitter ⚠
- p.Lys117Thr Single submitter
- p.Lys402Glu Single submitter ⚠
- p.Met534Ile Single submitter ⚠
- p.Phe528Tyr Single submitter ⚠
- p.Pro169Thr Single submitter ⚠
- p.Pro403Ser Single submitter ⚠
- p.Pro458Leu Single submitter ⚠
- p.Pro478Ser Single submitter ⚠
- p.Pro508Ala Single submitter ⚠
- p.Pro520Thr Single submitter ⚠
- p.Pro543Ser Single submitter ⚠
- p.Pro686Leu Single submitter ⚠
- p.Pro692Leu Single submitter ⚠
- p.Pro772Leu Single submitter ⚠
- p.Ser311Ile Single submitter ⚠
- p.Ser318Gly Single submitter
- p.Ser507Cys Single submitter ⚠
- p.Thr314Met Single submitter ⚠
- p.Thr336Ile Single submitter ⚠
- p.Thr536Ser Single submitter ⚠
- p.Thr564Ala Single submitter ⚠
- p.Thr625Met Single submitter ⚠
- p.Thr73Met Single submitter ⚠
- p.Val175Ile Single submitter ⚠
- p.Val210Ala Single submitter ⚠
- p.Val398Leu Single submitter ⚠
- p.Val444Met Single submitter
- p.Val467Ala Single submitter
- p.Val726Leu Single submitter ⚠