FUT4 — 92 ClinVar variants

All ClinVar germline FUT4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →

2 Benign · 11 Likely benign · 79 Uncertain significance

Full FUT4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 78

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 68

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 10

The independent predictors disagree with each other — read with care.

All FUT4 variants

Benign 2

p.Pro54= Multiple submitters
p.Leu265Met Single submitter

Likely benign 11

p.Asp516Glu Multiple submitters
p.Ala27Thr Single submitter
p.Arg34Trp Single submitter
p.Arg92Leu Single submitter
p.Asn312= Single submitter
p.Gly36= Single submitter
p.Pro133= Single submitter
p.Pro300= Single submitter
p.Ser526Arg Single submitter
p.Thr184Ala Single submitter
p.Trp115Arg Single submitter

Uncertain significance 79

p.Ala119Thr Single submitter ⚠
p.Ala120Gly Single submitter ⚠
p.Ala128Val Single submitter ⚠
p.Ala14Gly Single submitter ⚠
p.Ala14Ser Single submitter ⚠
p.Ala157Pro Single submitter ⚠
p.Ala204Pro Single submitter ⚠
p.Ala275Glu Single submitter ⚠
p.Ala275Val Single submitter ⚠
p.Ala46Val Single submitter ⚠
p.Ala480Thr Single submitter ⚠
p.Ala514Thr Single submitter ⚠
p.Ala525Val Single submitter ⚠
p.Ala64Thr Single submitter ⚠
p.Arg105Gly Single submitter ⚠
p.Arg140Trp Single submitter ⚠
p.Arg145Gly Single submitter ⚠
p.Arg147Gln Single submitter ⚠
p.Arg187Gln Single submitter ⚠
p.Arg214Cys Single submitter ⚠
p.Arg240His Single submitter ⚠
p.Arg352Gly Single submitter ⚠
p.Arg367Ser Single submitter ⚠
p.Arg428Cys Single submitter
p.Arg484Leu Single submitter ⚠
p.Arg522Trp Single submitter ⚠
p.Arg75Gln Single submitter ⚠
p.Arg87Gln Single submitter ⚠
p.Arg87Pro Single submitter ⚠
p.Arg95Gly Single submitter ⚠
p.Asn315Lys Single submitter ⚠
p.Asn315Thr Single submitter ⚠
p.Asn523Ser Single submitter ⚠
p.Asp269Tyr Single submitter ⚠
p.Asp325Glu Single submitter ⚠
p.Asp443Glu Single submitter ⚠
p.Cys106Gly Single submitter ⚠
p.Gln393Lys Single submitter ⚠
p.Glu103Gly Single submitter ⚠
p.Glu17Gln Single submitter ⚠
p.Glu17Lys Single submitter ⚠
p.Glu19Gln Single submitter ⚠
p.Glu502Lys Single submitter ⚠
p.Glu529Gln Single submitter ⚠
p.Gly148Arg Single submitter ⚠
p.Gly15Ala Single submitter ⚠
p.Gly160Asp Single submitter ⚠
p.Gly454Arg Single submitter ⚠
p.Ile167Phe Single submitter ⚠
p.Leu121Arg Single submitter ⚠
p.Leu121Val Single submitter ⚠
p.Leu222Pro Single submitter ⚠
p.Leu306Gln Single submitter ⚠
p.Leu432Phe Single submitter ⚠
p.Leu57Pro Single submitter ⚠
p.Phe409Leu Single submitter ⚠
p.Phe499Leu Single submitter ⚠
p.Pro185Ala Single submitter ⚠
p.Pro285Leu Single submitter ⚠
p.Pro287Ser Single submitter ⚠
p.Pro37Leu Single submitter ⚠
p.Pro391Leu Single submitter ⚠
p.Pro396Thr Single submitter ⚠
p.Pro63Ser Single submitter ⚠
p.Pro74Arg Single submitter ⚠
p.Pro76His Single submitter ⚠
p.Pro83Arg Single submitter ⚠
p.Ser32Ala Single submitter ⚠
p.Ser464Asn Single submitter ⚠
p.Ser86Cys Single submitter ⚠
p.Ser89Cys Single submitter ⚠
p.Thr110Met Single submitter ⚠
p.Thr403Ala Single submitter ⚠
p.Trp143Gly Single submitter ⚠
p.Trp172Leu Single submitter ⚠
p.Trp316Cys Single submitter ⚠
p.Val293Ile Single submitter ⚠
p.Val357Met Single submitter ⚠
p.Val459Met Single submitter ⚠