FUT5 — 111 ClinVar variants
All ClinVar germline FUT5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 98 flagged for review →
2 Benign · 13 Likely benign · 96 Uncertain significance
Full FUT5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 98
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FUT5 p.Ala101Gly Uncertain significance Single submitter
- FUT5 p.Ala101Val Uncertain significance Single submitter
- FUT5 p.Ala228Val Uncertain significance Single submitter
- FUT5 p.Ala277Ser Uncertain significance Single submitter
- FUT5 p.Ala277Thr Uncertain significance Single submitter
- FUT5 p.Ala27Val Uncertain significance Single submitter
- FUT5 p.Ala302Thr Uncertain significance Single submitter
- FUT5 p.Ala347Ser Uncertain significance Single submitter
- FUT5 p.Ala370Val Uncertain significance Single submitter
- FUT5 p.Ala90Ser Uncertain significance Single submitter
- FUT5 p.Ala90Thr Uncertain significance Single submitter
- FUT5 p.Arg14His Uncertain significance Single submitter
- FUT5 p.Arg157Gln Uncertain significance Single submitter
- FUT5 p.Arg157Trp Uncertain significance Single submitter
- FUT5 p.Arg15Cys Uncertain significance Single submitter
- FUT5 p.Arg275Ser Uncertain significance Single submitter
- FUT5 p.Arg317Trp Uncertain significance Single submitter
- FUT5 p.Arg336Gln Uncertain significance Single submitter
- FUT5 p.Arg340Gln Uncertain significance Single submitter
- FUT5 p.Arg35Cys Uncertain significance Single submitter
- FUT5 p.Arg35Ser Uncertain significance Single submitter
- FUT5 p.Arg367Leu Uncertain significance Single submitter
- FUT5 p.Arg63His Uncertain significance Single submitter
- FUT5 p.Asn105Thr Uncertain significance Single submitter
- FUT5 p.Asn198Ser Uncertain significance Single submitter
- FUT5 p.Asn212Thr Uncertain significance Single submitter
- FUT5 p.Asn60Asp Uncertain significance Single submitter
- FUT5 p.Asn60Ser Uncertain significance Single submitter
- FUT5 p.Asp103Asn Uncertain significance Single submitter
- FUT5 p.Asp233Asn Uncertain significance Single submitter
- FUT5 p.Asp267Asn Uncertain significance Single submitter
- FUT5 p.Asp301Asn Uncertain significance Single submitter
- FUT5 p.Asp39Asn Uncertain significance Single submitter
- FUT5 p.Asp40Asn Uncertain significance Single submitter
- FUT5 p.Cys16Ser Uncertain significance Single submitter
- FUT5 p.Gln115Arg Uncertain significance Single submitter
- FUT5 p.Glu295Gln Uncertain significance Single submitter
- FUT5 p.Gly164Arg Uncertain significance Single submitter
- FUT5 p.Gly190Ser Uncertain significance Single submitter
- FUT5 p.Gly19Arg Uncertain significance Single submitter
- FUT5 p.Gly236Arg Uncertain significance Single submitter
- FUT5 p.His326Tyr Uncertain significance Single submitter
- FUT5 p.Ile369Val Uncertain significance Single submitter
- FUT5 p.Ile78Leu Uncertain significance Single submitter
- FUT5 p.Leu162Val Uncertain significance Single submitter
- FUT5 p.Leu185Arg Uncertain significance Single submitter
- FUT5 p.Met150Leu Uncertain significance Single submitter
- FUT5 p.Met50Lys Uncertain significance Single submitter
- FUT5 p.Met97Thr Uncertain significance Single submitter
- FUT5 p.Phe256Leu Uncertain significance Single submitter
- FUT5 p.Pro196Leu Uncertain significance Single submitter
- FUT5 p.Pro215Leu Uncertain significance Single submitter
- FUT5 p.Pro3Thr Uncertain significance Single submitter
- FUT5 p.Pro54Thr Uncertain significance Single submitter
- FUT5 p.Ser149Asn Uncertain significance Single submitter
- FUT5 p.Ser217Leu Uncertain significance Single submitter
- FUT5 p.Ser290Arg Uncertain significance Single submitter
- FUT5 p.Ser32Phe Uncertain significance Single submitter
- FUT5 p.Thr180Met Uncertain significance Single submitter
- FUT5 p.Thr365Met Uncertain significance Single submitter
- FUT5 p.Thr75Asn Uncertain significance Single submitter
- FUT5 p.Tyr128His Uncertain significance Single submitter
- FUT5 p.Tyr257Cys Uncertain significance Single submitter
- FUT5 p.Tyr268Asn Uncertain significance Single submitter
- FUT5 p.Val286Met Uncertain significance Single submitter
- FUT5 p.Val28Met Uncertain significance Single submitter
- FUT5 p.Val366Ala Uncertain significance Single submitter
Predictors split 31
The independent predictors disagree with each other — read with care.
- FUT5 p.Thr338Met Benign Multiple submitters
- FUT5 p.Ala277Val Uncertain significance Single submitter
- FUT5 p.Ala349Asp Likely benign Single submitter
- FUT5 p.Ala353Asp Uncertain significance Single submitter
- FUT5 p.Arg144Cys Uncertain significance Single submitter
- FUT5 p.Arg173His Uncertain significance Single submitter
- FUT5 p.Arg221Cys Uncertain significance Single submitter
- FUT5 p.Arg253Trp Uncertain significance Single submitter
- FUT5 p.Arg336Leu Uncertain significance Single submitter
- FUT5 p.Arg367Cys Uncertain significance Single submitter
- FUT5 p.Asn276Lys Uncertain significance Single submitter
- FUT5 p.Asp177Asn Uncertain significance Single submitter
- FUT5 p.Asp177Tyr Uncertain significance Single submitter
- FUT5 p.Asp323Gly Uncertain significance Single submitter
- FUT5 p.Glu295Lys Uncertain significance Single submitter
- FUT5 p.Gly183Arg Uncertain significance Single submitter
- FUT5 p.Gly183Cys Uncertain significance Single submitter
- FUT5 p.Gly183Ser Uncertain significance Single submitter
- FUT5 p.Ile369Lys Uncertain significance Single submitter
- FUT5 p.Leu25Gln Uncertain significance Single submitter
- FUT5 p.Leu339Pro Uncertain significance Single submitter
- FUT5 p.Ser111Asn Likely benign Single submitter
- FUT5 p.Ser95Leu Uncertain significance Single submitter
- FUT5 p.Thr250Met Uncertain significance Single submitter
- FUT5 p.Trp372Leu Uncertain significance Single submitter
- FUT5 p.Tyr254His Uncertain significance Single submitter
- FUT5 p.Tyr332Cys Uncertain significance Single submitter
- FUT5 p.Tyr332His Uncertain significance Single submitter
- FUT5 p.Val283Met Uncertain significance Single submitter
- FUT5 p.Val285Met Uncertain significance Single submitter
- FUT5 p.Val306Met Uncertain significance Single submitter
All FUT5 variants
Benign 2
- p.His334Arg Multiple submitters
- p.Thr338Met Multiple submitters ⚠
Likely benign 13
- p.Ala209Val Single submitter
- p.Ala349Asp Single submitter ⚠
- p.Arg15His Single submitter
- p.Arg317Gln Single submitter
- p.Asp109Asn Single submitter
- p.Gln359Glu Single submitter
- p.Glu204Lys Single submitter
- p.His158Gln Single submitter
- p.Lys244Gln Single submitter
- p.Ser111Asn Single submitter ⚠
- p.Ser174Arg Single submitter
- p.Ser217= Single submitter
- p.Val89Met Single submitter
Uncertain significance 96
- p.Ala101Gly Single submitter ⚠
- p.Ala101Val Single submitter ⚠
- p.Ala228Val Single submitter ⚠
- p.Ala277Ser Single submitter ⚠
- p.Ala277Thr Single submitter ⚠
- p.Ala277Val Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala302Thr Single submitter ⚠
- p.Ala316Thr Single submitter
- p.Ala347Ser Single submitter ⚠
- p.Ala353Asp Single submitter ⚠
- p.Ala370Val Single submitter ⚠
- p.Ala90Ser Single submitter ⚠
- p.Ala90Thr Single submitter ⚠
- p.Arg144Cys Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg157Gln Single submitter ⚠
- p.Arg157Trp Single submitter ⚠
- p.Arg15Cys Single submitter ⚠
- p.Arg173His Single submitter ⚠
- p.Arg221Cys Single submitter ⚠
- p.Arg253Trp Single submitter ⚠
- p.Arg275Ser Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg336Gln Single submitter ⚠
- p.Arg336Leu Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg35Ser Single submitter ⚠
- p.Arg367Cys Single submitter ⚠
- p.Arg367Leu Single submitter ⚠
- p.Arg63His Single submitter ⚠
- p.Asn105Thr Single submitter ⚠
- p.Asn198Ser Single submitter ⚠
- p.Asn212Thr Single submitter ⚠
- p.Asn276Lys Single submitter ⚠
- p.Asn60Asp Single submitter ⚠
- p.Asn60Ser Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp177Asn Single submitter ⚠
- p.Asp177Tyr Single submitter ⚠
- p.Asp233Asn Single submitter ⚠
- p.Asp267Asn Single submitter ⚠
- p.Asp301Asn Single submitter ⚠
- p.Asp323Gly Single submitter ⚠
- p.Asp39Asn Single submitter ⚠
- p.Asp40Asn Single submitter ⚠
- p.Cys16Ser Single submitter ⚠
- p.Gln115Arg Single submitter ⚠
- p.Glu295Gln Single submitter ⚠
- p.Glu295Lys Single submitter ⚠
- p.Gly164Arg Single submitter ⚠
- p.Gly183Arg Single submitter ⚠
- p.Gly183Cys Single submitter ⚠
- p.Gly183Ser Single submitter ⚠
- p.Gly190Ser Single submitter ⚠
- p.Gly19Arg Single submitter ⚠
- p.Gly236Arg Single submitter ⚠
- p.His326Tyr Single submitter ⚠
- p.Ile369Lys Single submitter ⚠
- p.Ile369Val Single submitter ⚠
- p.Ile78Leu Single submitter ⚠
- p.Leu162Val Single submitter ⚠
- p.Leu185Arg Single submitter ⚠
- p.Leu25Gln Single submitter ⚠
- p.Leu339Pro Single submitter ⚠
- p.Met150Leu Single submitter ⚠
- p.Met50Lys Single submitter ⚠
- p.Met97Thr Single submitter ⚠
- p.Phe256Leu Single submitter ⚠
- p.Pro196Leu Single submitter ⚠
- p.Pro215Leu Single submitter ⚠
- p.Pro3Thr Single submitter ⚠
- p.Pro54Thr Single submitter ⚠
- p.Ser149Asn Single submitter ⚠
- p.Ser217Leu Single submitter ⚠
- p.Ser290Arg Single submitter ⚠
- p.Ser32Phe Single submitter ⚠
- p.Ser95Leu Single submitter ⚠
- p.Thr180Met Single submitter ⚠
- p.Thr250Met Single submitter ⚠
- p.Thr365Met Single submitter ⚠
- p.Thr75Asn Single submitter ⚠
- p.Trp372Leu Single submitter ⚠
- p.Tyr128His Single submitter ⚠
- p.Tyr254His Single submitter ⚠
- p.Tyr257Cys Single submitter ⚠
- p.Tyr268Asn Single submitter ⚠
- p.Tyr332Cys Single submitter ⚠
- p.Tyr332His Single submitter ⚠
- p.Val283Met Single submitter ⚠
- p.Val285Met Single submitter ⚠
- p.Val286Met Single submitter ⚠
- p.Val28Met Single submitter ⚠
- p.Val306Met Single submitter ⚠
- p.Val366Ala Single submitter ⚠