FUT6 — 101 ClinVar variants
All ClinVar germline FUT6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 84 flagged for review →
1 Conflicting · 2 Benign · 13 Likely benign · 85 Uncertain significance
Full FUT6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 84
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 58
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FUT6 p.Ala187Gly Uncertain significance Single submitter
- FUT6 p.Ala27Val Uncertain significance Single submitter
- FUT6 p.Ala339Ser Uncertain significance Single submitter
- FUT6 p.Ala76Val Uncertain significance Single submitter
- FUT6 p.Arg126Gln Uncertain significance Single submitter
- FUT6 p.Arg130Gln Uncertain significance Single submitter
- FUT6 p.Arg14His Uncertain significance Single submitter
- FUT6 p.Arg159His Uncertain significance Single submitter
- FUT6 p.Arg223His Uncertain significance Single submitter
- FUT6 p.Arg282Ser Uncertain significance Single submitter
- FUT6 p.Arg303Leu Uncertain significance Single submitter
- FUT6 p.Arg314His Uncertain significance Single submitter
- FUT6 p.Arg320His Uncertain significance Single submitter
- FUT6 p.Arg328His Uncertain significance Single submitter
- FUT6 p.Arg35Cys Uncertain significance Single submitter
- FUT6 p.Arg35His Uncertain significance Single submitter
- FUT6 p.Arg49His Uncertain significance Single submitter
- FUT6 p.Arg79His Uncertain significance Single submitter
- FUT6 p.Arg96His Uncertain significance Single submitter
- FUT6 p.Asn198Ser Uncertain significance Single submitter
- FUT6 p.Asn46Lys Uncertain significance Single submitter
- FUT6 p.Asn91Thr Uncertain significance Single submitter
- FUT6 p.Asp40Asn Uncertain significance Single submitter
- FUT6 p.Asp52Val Uncertain significance Single submitter
- FUT6 p.Cys142Ser Uncertain significance Single submitter
- FUT6 p.Cys16Ser Uncertain significance Single submitter
- FUT6 p.Gln144Lys Uncertain significance Single submitter
- FUT6 p.Gln38His Uncertain significance Single submitter
- FUT6 p.Glu190Gln Uncertain significance Single submitter
-
FUT6 p.Glu247Lys
Uncertain significance
Single submitter
fucosyltransferase 6 deficiency
- FUT6 p.Glu323Gly Uncertain significance Single submitter
- FUT6 p.Gly150Arg Uncertain significance Single submitter
- FUT6 p.Gly176Ser Uncertain significance Single submitter
- FUT6 p.Gly222Arg Uncertain significance Single submitter
- FUT6 p.His180Tyr Uncertain significance Single submitter
- FUT6 p.His59Gln Uncertain significance Single submitter
- FUT6 p.His59Tyr Uncertain significance Single submitter
- FUT6 p.Ile75Met Uncertain significance Single submitter
- FUT6 p.Leu284Val Uncertain significance Single submitter
- FUT6 p.Leu66Met Uncertain significance Single submitter
- FUT6 p.Lys299Arg Uncertain significance Single submitter
- FUT6 p.Met233Val Uncertain significance Single submitter
- FUT6 p.Pro116Ser Uncertain significance Single submitter
- FUT6 p.Pro173Leu Uncertain significance Single submitter
- FUT6 p.Pro181Ser Uncertain significance Single submitter
- FUT6 p.Pro252Ser Uncertain significance Single submitter
- FUT6 p.Pro327Ser Uncertain significance Single submitter
- FUT6 p.Pro3Ser Uncertain significance Single submitter
- FUT6 p.Ser211Gly Uncertain significance Single submitter
- FUT6 p.Ser48Pro Uncertain significance Single submitter
- FUT6 p.Thr232Asn Uncertain significance Single submitter
- FUT6 p.Trp133Arg Uncertain significance Single submitter
- FUT6 p.Trp194Arg Uncertain significance Single submitter
- FUT6 p.Tyr168Asn Uncertain significance Single submitter
- FUT6 p.Tyr243Cys Uncertain significance Single submitter
- FUT6 p.Tyr44Asn Uncertain significance Single submitter
- FUT6 p.Val107Met Uncertain significance Single submitter
- FUT6 p.Val196Ala Uncertain significance Single submitter
Predictors split 26
The independent predictors disagree with each other — read with care.
-
FUT6 p.Pro124Ser
Benign
Multiple submitters
fucosyltransferase 6 deficiency
- FUT6 p.Ala104Gly Uncertain significance Single submitter
- FUT6 p.Ala104Thr Uncertain significance Single submitter
- FUT6 p.Ala104Val Uncertain significance Single submitter
- FUT6 p.Ala263Thr Uncertain significance Single submitter
- FUT6 p.Arg314Cys Uncertain significance Single submitter
- FUT6 p.Arg320Cys Uncertain significance Single submitter
- FUT6 p.Arg322Trp Uncertain significance Single submitter
- FUT6 p.Arg328Cys Uncertain significance Single submitter
- FUT6 p.Arg79Cys Uncertain significance Single submitter
- FUT6 p.Asn153Ser Uncertain significance Single submitter
- FUT6 p.Asp161Asn Uncertain significance Single submitter
- FUT6 p.Asp163Asn Uncertain significance Single submitter
- FUT6 p.Asp293Tyr Uncertain significance Single submitter
- FUT6 p.Asp294Asn Uncertain significance Single submitter
- FUT6 p.Gln344Pro Uncertain significance Single submitter
- FUT6 p.His108Arg Uncertain significance Single submitter
- FUT6 p.Leu145Pro Uncertain significance Single submitter
- FUT6 p.Met156Ile Uncertain significance Single submitter
- FUT6 p.Pro124Arg Uncertain significance Single submitter
- FUT6 p.Thr93Ile Uncertain significance Single submitter
- FUT6 p.Trp332Leu Uncertain significance Single submitter
- FUT6 p.Tyr243His Uncertain significance Single submitter
- FUT6 p.Val269Leu Uncertain significance Single submitter
- FUT6 p.Val271Met Uncertain significance Single submitter
- FUT6 p.Phe319Leu Uncertain significance No assertion criteria
All FUT6 variants
Conflicting classifications of pathogenicity 1
- p.Tyr315Ter Single submitter fucosyltransferase 6 deficiency
Benign 2
- p.Arg303Gly Multiple submitters fucosyltransferase 6 deficiency
- p.Pro124Ser Multiple submitters fucosyltransferase 6 deficiency ⚠
Likely benign 13
- p.Ala195= Multiple submitters
- p.Ala214= Single submitter
- p.Ala58Thr Single submitter
- p.Arg126Trp Single submitter
- p.Glu190Lys Single submitter
- p.Glu345Gln Single submitter
- p.Gly231= Single submitter
- p.Gly353Ser Single submitter
- p.Leu21= Single submitter
- p.Pro270= Single submitter
- p.Thr324Met Single submitter
- p.Thr87Met Single submitter
- p.Asn46= No assertion criteria FUT6-related disorder
Uncertain significance 85
- p.Ala104Gly Single submitter ⚠
- p.Ala104Thr Single submitter ⚠
- p.Ala104Val Single submitter ⚠
- p.Ala187Gly Single submitter ⚠
- p.Ala263Thr Single submitter ⚠
- p.Ala27Val Single submitter ⚠
- p.Ala339Ser Single submitter ⚠
- p.Ala76Val Single submitter ⚠
- p.Arg126Gln Single submitter ⚠
- p.Arg130Gln Single submitter ⚠
- p.Arg14His Single submitter ⚠
- p.Arg159Cys Single submitter
- p.Arg159His Single submitter ⚠
- p.Arg223His Single submitter ⚠
- p.Arg282Ser Single submitter ⚠
- p.Arg303Leu Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg314His Single submitter ⚠
- p.Arg320Cys Single submitter ⚠
- p.Arg320His Single submitter ⚠
- p.Arg322Trp Single submitter ⚠
- p.Arg328Cys Single submitter ⚠
- p.Arg328His Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg49His Single submitter ⚠
- p.Arg79Cys Single submitter ⚠
- p.Arg79His Single submitter ⚠
- p.Arg96His Single submitter ⚠
- p.Asn153Ser Single submitter ⚠
- p.Asn198Ser Single submitter ⚠
- p.Asn46Lys Single submitter ⚠
- p.Asn91Thr Single submitter ⚠
- p.Asp161Asn Single submitter ⚠
- p.Asp163Asn Single submitter ⚠
- p.Asp293Tyr Single submitter ⚠
- p.Asp294Asn Single submitter ⚠
- p.Asp40Asn Single submitter ⚠
- p.Asp52Val Single submitter ⚠
- p.Cys142Ser Single submitter ⚠
- p.Cys16Ser Single submitter ⚠
- p.Gln144Lys Single submitter ⚠
- p.Gln344Pro Single submitter ⚠
- p.Gln38His Single submitter ⚠
- p.Glu190Gln Single submitter ⚠
- p.Glu247Lys Single submitter fucosyltransferase 6 deficiency ⚠
- p.Glu323Gly Single submitter ⚠
- p.Gly150Arg Single submitter ⚠
- p.Gly176Ser Single submitter ⚠
- p.Gly222Arg Single submitter ⚠
- p.His108Arg Single submitter ⚠
- p.His180Tyr Single submitter ⚠
- p.His59Gln Single submitter ⚠
- p.His59Tyr Single submitter ⚠
- p.Ile75Met Single submitter ⚠
- p.Leu145Pro Single submitter ⚠
- p.Leu284Val Single submitter ⚠
- p.Leu66Met Single submitter ⚠
- p.Lys299Arg Single submitter ⚠
- p.Met156Ile Single submitter ⚠
- p.Met233Val Single submitter ⚠
- p.Pro116Ser Single submitter ⚠
- p.Pro124Arg Single submitter ⚠
- p.Pro173Leu Single submitter ⚠
- p.Pro181Ser Single submitter ⚠
- p.Pro252Ser Single submitter ⚠
- p.Pro327Ser Single submitter ⚠
- p.Pro3Ser Single submitter ⚠
- p.Ser211Gly Single submitter ⚠
- p.Ser48Pro Single submitter ⚠
- p.Thr232Asn Single submitter ⚠
- p.Thr93Ile Single submitter ⚠
- p.Thr93Pro Single submitter
- p.Trp133Arg Single submitter ⚠
- p.Trp194Arg Single submitter ⚠
- p.Trp332Leu Single submitter ⚠
- p.Tyr168Asn Single submitter ⚠
- p.Tyr243Cys Single submitter ⚠
- p.Tyr243His Single submitter ⚠
- p.Tyr44Asn Single submitter ⚠
- p.Val107Met Single submitter ⚠
- p.Val196Ala Single submitter ⚠
- p.Val269Leu Single submitter ⚠
- p.Val271Met Single submitter ⚠
- p.Phe319Leu No assertion criteria ⚠