FXR2 — 91 ClinVar variants
All ClinVar germline FXR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 83 flagged for review →
1 Benign · 4 Likely benign · 86 Uncertain significance
Full FXR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 83
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 66
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FXR2 p.Ala407Val Uncertain significance Single submitter
- FXR2 p.Ala466Ser Uncertain significance Single submitter
- FXR2 p.Ala5Val Uncertain significance Single submitter
- FXR2 p.Arg327Gln Uncertain significance Single submitter
- FXR2 p.Arg423Gln Uncertain significance Single submitter
- FXR2 p.Arg436Gln Uncertain significance Single submitter
- FXR2 p.Arg460Thr Uncertain significance Single submitter
- FXR2 p.Arg465Gln Uncertain significance Single submitter
- FXR2 p.Arg471Lys Uncertain significance Single submitter
- FXR2 p.Arg497Gln Uncertain significance Single submitter
- FXR2 p.Arg546His Uncertain significance Single submitter
- FXR2 p.Arg594His Uncertain significance Single submitter
- FXR2 p.Arg606Cys Uncertain significance Single submitter
- FXR2 p.Arg606His Uncertain significance Single submitter
- FXR2 p.Arg630His Uncertain significance Single submitter
- FXR2 p.Asn128Ser Uncertain significance Single submitter
- FXR2 p.Asn155Ser Uncertain significance Single submitter
- FXR2 p.Asn503Ser Uncertain significance Single submitter
- FXR2 p.Asn570His Uncertain significance Single submitter
- FXR2 p.Asn596Ser Uncertain significance Single submitter
- FXR2 p.Asp470Asn Uncertain significance Single submitter
- FXR2 p.Asp599Val Uncertain significance Single submitter
- FXR2 p.Asp636Glu Uncertain significance Single submitter
- FXR2 p.Cys151Ser Uncertain significance Single submitter
- FXR2 p.Gln583His Uncertain significance Single submitter
- FXR2 p.Glu377Gln Uncertain significance Single submitter
- FXR2 p.Glu83Ala Uncertain significance Single submitter
- FXR2 p.Gly400Ser Uncertain significance Single submitter
- FXR2 p.Gly402Ser Uncertain significance Single submitter
- FXR2 p.Gly427Ser Uncertain significance Single submitter
- FXR2 p.Gly431Ser Uncertain significance Single submitter
- FXR2 p.Gly440Ser Uncertain significance Single submitter
- FXR2 p.Gly486Ala Uncertain significance Single submitter
- FXR2 p.Gly486Arg Uncertain significance Single submitter
- FXR2 p.Gly55Arg Uncertain significance Single submitter
- FXR2 p.Gly562Ala Uncertain significance Single submitter
- FXR2 p.Gly643Ser Uncertain significance Single submitter
- FXR2 p.Gly657Val Uncertain significance Single submitter
- FXR2 p.Gly7Arg Uncertain significance Single submitter
- FXR2 p.Gly8Ala Uncertain significance Single submitter
- FXR2 p.His420Asn Uncertain significance Single submitter
- FXR2 p.Ile602Val Uncertain significance Single submitter
- FXR2 p.Leu4Val Uncertain significance Single submitter
- FXR2 p.Leu576Pro Uncertain significance Single submitter
- FXR2 p.Leu638Val Uncertain significance Single submitter
- FXR2 p.Lys632Thr Uncertain significance Single submitter
- FXR2 p.Pro445Thr Uncertain significance Single submitter
- FXR2 p.Pro474Arg Uncertain significance Single submitter
- FXR2 p.Pro494Leu Uncertain significance Single submitter
- FXR2 p.Pro530Leu Uncertain significance Single submitter
- FXR2 p.Pro538Arg Uncertain significance Single submitter
- FXR2 p.Pro538Leu Uncertain significance Single submitter
- FXR2 p.Pro540Thr Uncertain significance Single submitter
- FXR2 p.Pro626Gln Uncertain significance Single submitter
- FXR2 p.Pro633Leu Uncertain significance Single submitter
- FXR2 p.Ser480Thr Uncertain significance Single submitter
- FXR2 p.Ser620Ala Uncertain significance Single submitter
- FXR2 p.Ser654Leu Uncertain significance Single submitter
- FXR2 p.Ser6Phe Uncertain significance Single submitter
- FXR2 p.Thr475Ser Uncertain significance Single submitter
- FXR2 p.Tyr429His Uncertain significance Single submitter
- FXR2 p.Tyr429Ser Uncertain significance Single submitter
- FXR2 p.Val156Ile Uncertain significance Single submitter
- FXR2 p.Val559Ile Uncertain significance Single submitter
- FXR2 p.Val559Leu Uncertain significance Single submitter
- FXR2 p.Val669Leu Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- FXR2 p.Arg375His Uncertain significance Single submitter
- FXR2 p.Arg434His Uncertain significance Single submitter
- FXR2 p.Arg497Trp Uncertain significance Single submitter
- FXR2 p.Arg549Cys Uncertain significance Single submitter
- FXR2 p.Arg549Gly Uncertain significance Single submitter
- FXR2 p.Arg549His Uncertain significance Single submitter
- FXR2 p.Arg550His Uncertain significance Single submitter
- FXR2 p.Arg551Cys Uncertain significance Single submitter
- FXR2 p.Arg552Cys Uncertain significance Single submitter
- FXR2 p.Arg591His Uncertain significance Single submitter
- FXR2 p.Arg93Trp Uncertain significance Single submitter
- FXR2 p.Asp613Gly Uncertain significance Single submitter
- FXR2 p.Glu456Lys Uncertain significance Single submitter
- FXR2 p.Met209Arg Uncertain significance Single submitter
- FXR2 p.Met560Lys Uncertain significance Single submitter
- FXR2 p.Ser366Cys Uncertain significance Single submitter
- FXR2 p.Val611Met Uncertain significance Single submitter
All FXR2 variants
Benign 1
- p.Pro473= Multiple submitters
Likely benign 4
- p.Lys651Glu Multiple submitters
- p.Arg483Gln Single submitter
- p.Pro279= Single submitter
- p.Ser152= Single submitter
Uncertain significance 86
- p.Ala166Val Single submitter
- p.Ala407Val Single submitter ⚠
- p.Ala466Ser Single submitter ⚠
- p.Ala5Val Single submitter ⚠
- p.Arg327Gln Single submitter ⚠
- p.Arg375His Single submitter ⚠
- p.Arg423Gln Single submitter ⚠
- p.Arg434His Single submitter ⚠
- p.Arg436Gln Single submitter ⚠
- p.Arg460Thr Single submitter ⚠
- p.Arg465Gln Single submitter ⚠
- p.Arg471Lys Single submitter ⚠
- p.Arg497Gln Single submitter ⚠
- p.Arg497Trp Single submitter ⚠
- p.Arg545Cys Single submitter
- p.Arg546His Single submitter ⚠
- p.Arg549Cys Single submitter ⚠
- p.Arg549Gly Single submitter ⚠
- p.Arg549His Single submitter ⚠
- p.Arg550His Single submitter ⚠
- p.Arg551Cys Single submitter ⚠
- p.Arg552Cys Single submitter ⚠
- p.Arg591His Single submitter ⚠
- p.Arg594His Single submitter ⚠
- p.Arg606Cys Single submitter ⚠
- p.Arg606His Single submitter ⚠
- p.Arg630His Single submitter ⚠
- p.Arg93Trp Single submitter ⚠
- p.Asn128Ser Single submitter ⚠
- p.Asn155Ser Single submitter ⚠
- p.Asn503Ser Single submitter ⚠
- p.Asn570His Single submitter ⚠
- p.Asn596Ser Single submitter ⚠
- p.Asp470Asn Single submitter ⚠
- p.Asp561Gly Single submitter
- p.Asp599Val Single submitter ⚠
- p.Asp613Gly Single submitter ⚠
- p.Asp636Glu Single submitter ⚠
- p.Cys151Ser Single submitter ⚠
- p.Gln583His Single submitter ⚠
- p.Glu377Gln Single submitter ⚠
- p.Glu456Lys Single submitter ⚠
- p.Glu83Ala Single submitter ⚠
- p.Gly400Ser Single submitter ⚠
- p.Gly402Ser Single submitter ⚠
- p.Gly427Ser Single submitter ⚠
- p.Gly431Ser Single submitter ⚠
- p.Gly440Ser Single submitter ⚠
- p.Gly486Ala Single submitter ⚠
- p.Gly486Arg Single submitter ⚠
- p.Gly55Arg Single submitter ⚠
- p.Gly562Ala Single submitter ⚠
- p.Gly643Ser Single submitter ⚠
- p.Gly657Val Single submitter ⚠
- p.Gly7Arg Single submitter ⚠
- p.Gly8Ala Single submitter ⚠
- p.His420Asn Single submitter ⚠
- p.Ile602Val Single submitter ⚠
- p.Leu4Val Single submitter ⚠
- p.Leu576Pro Single submitter ⚠
- p.Leu638Val Single submitter ⚠
- p.Lys632Thr Single submitter ⚠
- p.Met209Arg Single submitter ⚠
- p.Met560Lys Single submitter ⚠
- p.Pro445Thr Single submitter ⚠
- p.Pro474Arg Single submitter ⚠
- p.Pro494Leu Single submitter ⚠
- p.Pro530Leu Single submitter ⚠
- p.Pro538Arg Single submitter ⚠
- p.Pro538Leu Single submitter ⚠
- p.Pro540Thr Single submitter ⚠
- p.Pro626Gln Single submitter ⚠
- p.Pro633Leu Single submitter ⚠
- p.Ser366Cys Single submitter ⚠
- p.Ser480Thr Single submitter ⚠
- p.Ser620Ala Single submitter ⚠
- p.Ser654Leu Single submitter ⚠
- p.Ser6Phe Single submitter ⚠
- p.Thr475Ser Single submitter ⚠
- p.Tyr429His Single submitter ⚠
- p.Tyr429Ser Single submitter ⚠
- p.Val156Ile Single submitter ⚠
- p.Val559Ile Single submitter ⚠
- p.Val559Leu Single submitter ⚠
- p.Val611Met Single submitter ⚠
- p.Val669Leu Single submitter ⚠