FYN — 30 ClinVar variants
All ClinVar germline FYN variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 17 flagged for review →
3 Pathogenic · 6 Benign · 3 Likely benign · 18 Uncertain significance
Full FYN gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 17
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
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FYN p.Thr97Ala
Pathogenic
No assertion criteria
EBV-positive nodal T- and NK-cell lymphoma
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FYN p.Ala55Thr Uncertain significance Single submitter
- FYN p.Arg29Cys Uncertain significance Single submitter
- FYN p.Asp8Glu Uncertain significance Single submitter
- FYN p.Gln272Glu Uncertain significance Single submitter
- FYN p.Glu233Asp Uncertain significance Single submitter
- FYN p.Leu402Phe Uncertain significance Single submitter
- FYN p.Ser307Ala Uncertain significance Single submitter
- FYN p.Ser307Tyr Uncertain significance Single submitter
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FYN p.Ser69Cys
Uncertain significance
Single submitter
primary ovarian failure
- FYN p.Thr62Ala Uncertain significance Single submitter
- FYN p.Tyr91His Uncertain significance Single submitter
- FYN p.Val368Ala Uncertain significance Single submitter
- FYN p.Val63Ile Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All FYN variants
Pathogenic 3
- p.Arg96Gly No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Arg96Trp No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
- p.Thr97Ala No assertion criteria EBV-positive nodal T- and NK-cell lymphoma ⚠
Benign 6
- p.Asp506Glu Multiple submitters
- c.1119+8C>A Single submitter
- c.1120-10G>A Single submitter
- c.1273+8C>T Single submitter
- p.His323= Single submitter
- p.Phe42= Single submitter
Likely benign 3
- p.His54= Single submitter
- p.Pro488= Single submitter
- p.Ser518Gly Single submitter
Uncertain significance 18
- c.344+1G>A Single submitter
- p.Ala55Thr Single submitter ⚠
- p.Arg123Cys Single submitter ⚠
- p.Arg161Ter Single submitter
- p.Arg29Cys Single submitter ⚠
- p.Asp8Glu Single submitter ⚠
- p.Asp92Asn Single submitter ⚠
- p.Gln272Glu Single submitter ⚠
- p.Glu233Asp Single submitter ⚠
- p.Leu271Val Single submitter ⚠
- p.Leu402Phe Single submitter ⚠
- p.Ser307Ala Single submitter ⚠
- p.Ser307Tyr Single submitter ⚠
- p.Ser69Cys Single submitter primary ovarian failure ⚠
- p.Thr62Ala Single submitter ⚠
- p.Tyr91His Single submitter ⚠
- p.Val368Ala Single submitter ⚠
- p.Val63Ile Single submitter ⚠