FZD7 — 63 ClinVar variants
All ClinVar germline FZD7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 59 flagged for review →
2 Benign · 1 Likely benign · 60 Uncertain significance
Full FZD7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 59
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- FZD7 p.Ala133Ser Uncertain significance Single submitter
- FZD7 p.Ala182Thr Uncertain significance Single submitter
- FZD7 p.Ala205Pro Uncertain significance Single submitter
- FZD7 p.Ala205Val Uncertain significance Single submitter
- FZD7 p.Ala253Val Uncertain significance Single submitter
- FZD7 p.Ala376Val Uncertain significance Single submitter
- FZD7 p.Ala384Asp Uncertain significance Single submitter
- FZD7 p.Ala420Ser Uncertain significance Single submitter
- FZD7 p.Arg121Gly Uncertain significance Single submitter
- FZD7 p.Arg203His Uncertain significance Single submitter
- FZD7 p.Arg212Cys Uncertain significance Single submitter
- FZD7 p.Arg280Trp Uncertain significance Single submitter
- FZD7 p.Arg312Ser Uncertain significance Single submitter
- FZD7 p.Arg451Cys Uncertain significance Single submitter
- FZD7 p.Asp45Asn Uncertain significance Single submitter
- FZD7 p.Gln115His Uncertain significance Single submitter
- FZD7 p.Gln129Lys Uncertain significance Single submitter
- FZD7 p.Glu38Asp Uncertain significance Single submitter
- FZD7 p.Gly170Arg Uncertain significance Single submitter
- FZD7 p.Gly200Asp Uncertain significance Single submitter
- FZD7 p.Gly347Ser Uncertain significance Single submitter
- FZD7 p.Gly366Asp Uncertain significance Single submitter
- FZD7 p.Gly541Arg Uncertain significance Single submitter
- FZD7 p.Ile52Val Uncertain significance Single submitter
- FZD7 p.Leu113Val Uncertain significance Single submitter
- FZD7 p.Leu185Val Uncertain significance Single submitter
- FZD7 p.Leu255Val Uncertain significance Single submitter
- FZD7 p.Leu406Val Uncertain significance Single submitter
- FZD7 p.Leu67Met Uncertain significance Single submitter
- FZD7 p.Lys246Glu Uncertain significance Single submitter
- FZD7 p.Lys533Thr Uncertain significance Single submitter
- FZD7 p.Lys569Arg Uncertain significance Single submitter
- FZD7 p.Met531Val Uncertain significance Single submitter
- FZD7 p.Pro180Ser Uncertain significance Single submitter
- FZD7 p.Pro195Leu Uncertain significance Single submitter
- FZD7 p.Pro204Ala Uncertain significance Single submitter
- FZD7 p.Pro204His Uncertain significance Single submitter
- FZD7 p.Pro514Ser Uncertain significance Single submitter
- FZD7 p.Pro55Gln Uncertain significance Single submitter
- FZD7 p.Pro96Ser Uncertain significance Single submitter
- FZD7 p.Ser122Phe Uncertain significance Single submitter
- FZD7 p.Ser567Asn Uncertain significance Single submitter
- FZD7 p.Thr177Asn Uncertain significance Single submitter
- FZD7 p.Thr191Ser Uncertain significance Single submitter
- FZD7 p.Thr459Ser Uncertain significance Single submitter
- FZD7 p.Thr572Ile Uncertain significance Single submitter
- FZD7 p.Thr74Met Uncertain significance Single submitter
- FZD7 p.Val216Leu Uncertain significance Single submitter
- FZD7 p.Val272Ile Uncertain significance Single submitter
- FZD7 p.Val316Ala Uncertain significance Single submitter
- FZD7 p.Val388Leu Uncertain significance Single submitter
- FZD7 p.Val473Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- FZD7 p.Ala494Val Uncertain significance Single submitter
- FZD7 p.Asp322Tyr Uncertain significance Single submitter
- FZD7 p.Ile450Val Uncertain significance Single submitter
- FZD7 p.Met538Thr Uncertain significance Single submitter
- FZD7 p.Pro44Ser Uncertain significance Single submitter
- FZD7 p.Ser320Leu Uncertain significance Single submitter
- FZD7 p.Val109Met Uncertain significance Single submitter
All FZD7 variants
Benign 2
- p.Gly196Glu Multiple submitters
- p.Gly409= Multiple submitters
Likely benign 1
- p.Leu263= Single submitter
Uncertain significance 60
- p.Ala133Ser Single submitter ⚠
- p.Ala182Thr Single submitter ⚠
- p.Ala205Pro Single submitter ⚠
- p.Ala205Val Single submitter ⚠
- p.Ala253Thr Single submitter
- p.Ala253Val Single submitter ⚠
- p.Ala376Val Single submitter ⚠
- p.Ala384Asp Single submitter ⚠
- p.Ala420Ser Single submitter ⚠
- p.Ala494Val Single submitter ⚠
- p.Arg121Gly Single submitter ⚠
- p.Arg203His Single submitter ⚠
- p.Arg212Cys Single submitter ⚠
- p.Arg280Trp Single submitter ⚠
- p.Arg312Ser Single submitter ⚠
- p.Arg451Cys Single submitter ⚠
- p.Asp322Tyr Single submitter ⚠
- p.Asp45Asn Single submitter ⚠
- p.Gln115His Single submitter ⚠
- p.Gln129Lys Single submitter ⚠
- p.Glu38Asp Single submitter ⚠
- p.Gly170Arg Single submitter ⚠
- p.Gly200Asp Single submitter ⚠
- p.Gly347Ser Single submitter ⚠
- p.Gly366Asp Single submitter ⚠
- p.Gly541Arg Single submitter ⚠
- p.Ile450Val Single submitter ⚠
- p.Ile52Val Single submitter ⚠
- p.Leu113Val Single submitter ⚠
- p.Leu185Val Single submitter ⚠
- p.Leu255Val Single submitter ⚠
- p.Leu406Val Single submitter ⚠
- p.Leu67Met Single submitter ⚠
- p.Lys246Glu Single submitter ⚠
- p.Lys533Thr Single submitter ⚠
- p.Lys569Arg Single submitter ⚠
- p.Met531Val Single submitter ⚠
- p.Met538Thr Single submitter ⚠
- p.Pro180Ser Single submitter ⚠
- p.Pro195Leu Single submitter ⚠
- p.Pro204Ala Single submitter ⚠
- p.Pro204His Single submitter ⚠
- p.Pro44Ser Single submitter ⚠
- p.Pro514Ser Single submitter ⚠
- p.Pro55Gln Single submitter ⚠
- p.Pro96Ser Single submitter ⚠
- p.Ser122Phe Single submitter ⚠
- p.Ser320Leu Single submitter ⚠
- p.Ser567Asn Single submitter ⚠
- p.Thr177Asn Single submitter ⚠
- p.Thr191Ser Single submitter ⚠
- p.Thr459Ser Single submitter ⚠
- p.Thr572Ile Single submitter ⚠
- p.Thr74Met Single submitter ⚠
- p.Val109Met Single submitter ⚠
- p.Val216Leu Single submitter ⚠
- p.Val272Ile Single submitter ⚠
- p.Val316Ala Single submitter ⚠
- p.Val388Leu Single submitter ⚠
- p.Val473Ile Single submitter ⚠