G3BP2 — 31 ClinVar variants
All ClinVar germline G3BP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 25 flagged for review →
2 Likely benign · 29 Uncertain significance
Full G3BP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 25
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 19
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- G3BP2 p.Ala280Thr Uncertain significance Single submitter
- G3BP2 p.Arg295Gln Uncertain significance Single submitter
- G3BP2 p.Arg401Cys Uncertain significance Single submitter
- G3BP2 p.Asn430Ser Uncertain significance Single submitter
- G3BP2 p.Gln472His Uncertain significance Single submitter
- G3BP2 p.Gln58His Uncertain significance Single submitter
- G3BP2 p.Glu156Asp Uncertain significance Single submitter
- G3BP2 p.Glu207Asp Uncertain significance Single submitter
- G3BP2 p.Glu219Gln Uncertain significance Single submitter
- G3BP2 p.Gly475Ser Uncertain significance Single submitter
- G3BP2 p.His194Asn Uncertain significance Single submitter
- G3BP2 p.Ile185Val Uncertain significance Single submitter
- G3BP2 p.Ile394Ser Uncertain significance Single submitter
- G3BP2 p.Met314Thr Uncertain significance Single submitter
- G3BP2 p.Met460Leu Uncertain significance Single submitter
- G3BP2 p.Pro188Arg Uncertain significance Single submitter
- G3BP2 p.Pro230Leu Uncertain significance Single submitter
- G3BP2 p.Pro266Ser Uncertain significance Single submitter
- G3BP2 p.Ser173Cys Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- G3BP2 p.Arg361His Uncertain significance Single submitter
- G3BP2 p.Glu203Gly Uncertain significance Single submitter
- G3BP2 p.Glu215Gly Uncertain significance Single submitter
- G3BP2 p.Glu298Gly Uncertain significance Single submitter
- G3BP2 p.Gly444Val Uncertain significance Single submitter
- G3BP2 p.Ile362Leu Uncertain significance Single submitter
All G3BP2 variants
Likely benign 2
- p.Thr226Ala Single submitter
- p.Val278= Single submitter
Uncertain significance 29
- c.178-1G>A Single submitter
- p.Ala280Thr Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg323Lys Single submitter
- p.Arg361His Single submitter ⚠
- p.Arg401Cys Single submitter ⚠
- p.Arg447His Single submitter
- p.Asn430Ser Single submitter ⚠
- p.Gln472His Single submitter ⚠
- p.Gln58His Single submitter ⚠
- p.Glu156Asp Single submitter ⚠
- p.Glu159Lys Single submitter
- p.Glu203Gly Single submitter ⚠
- p.Glu207Asp Single submitter ⚠
- p.Glu215Gly Single submitter ⚠
- p.Glu219Gln Single submitter ⚠
- p.Glu298Gly Single submitter ⚠
- p.Gly444Val Single submitter ⚠
- p.Gly475Ser Single submitter ⚠
- p.His194Asn Single submitter ⚠
- p.Ile185Val Single submitter ⚠
- p.Ile362Leu Single submitter ⚠
- p.Ile394Ser Single submitter ⚠
- p.Met314Thr Single submitter ⚠
- p.Met460Leu Single submitter ⚠
- p.Pro188Arg Single submitter ⚠
- p.Pro230Leu Single submitter ⚠
- p.Pro266Ser Single submitter ⚠
- p.Ser173Cys Single submitter ⚠