GABARAPL1 — 9 ClinVar variants
All ClinVar germline GABARAPL1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
9 Uncertain significance
Full GABARAPL1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 7
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GABARAPL1 p.Arg67Ile Uncertain significance Single submitter
- GABARAPL1 p.Met91Thr Uncertain significance Single submitter
- GABARAPL1 p.Phe11Ser Uncertain significance Single submitter
- GABARAPL1 p.Pro42Ser Uncertain significance Single submitter
- GABARAPL1 p.Tyr103Cys Uncertain significance Single submitter
- GABARAPL1 p.Tyr95His Uncertain significance Single submitter
- GABARAPL1 p.Val29Asp Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All GABARAPL1 variants
Uncertain significance 9
- p.Arg67Ile Single submitter ⚠
- p.Asp43Val Single submitter
- p.Met91Thr Single submitter ⚠
- p.Met91Val Single submitter ⚠
- p.Phe11Ser Single submitter ⚠
- p.Pro42Ser Single submitter ⚠
- p.Tyr103Cys Single submitter ⚠
- p.Tyr95His Single submitter ⚠
- p.Val29Asp Single submitter ⚠