GABARAPL2 — 8 ClinVar variants
All ClinVar germline GABARAPL2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 8 flagged for review →
8 Uncertain significance
Full GABARAPL2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 8
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GABARAPL2 p.His9Asp Uncertain significance Single submitter
- GABARAPL2 p.Ile44Thr Uncertain significance Single submitter
- GABARAPL2 p.Leu105Ser Uncertain significance Single submitter
- GABARAPL2 p.Ser110Arg Uncertain significance Single submitter
- GABARAPL2 p.Ser39Tyr Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All GABARAPL2 variants
Uncertain significance 8
- p.Glu7Lys Single submitter ⚠
- p.His9Asp Single submitter ⚠
- p.Ile41Thr Single submitter ⚠
- p.Ile44Thr Single submitter ⚠
- p.Leu105Ser Single submitter ⚠
- p.Lys6Arg Single submitter ⚠
- p.Ser110Arg Single submitter ⚠
- p.Ser39Tyr Single submitter ⚠