GABRG1 — 60 ClinVar variants
All ClinVar germline GABRG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 55 flagged for review →
1 Benign/Likely benign · 59 Uncertain significance
Full GABRG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 55
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GABRG1 p.Ala56Thr Uncertain significance Single submitter
- GABRG1 p.Arg169Leu Uncertain significance Single submitter
- GABRG1 p.Asn214Lys Uncertain significance Single submitter
- GABRG1 p.Asn360Ser Uncertain significance Single submitter
- GABRG1 p.Asn392Ser Uncertain significance Single submitter
- GABRG1 p.Asp401Asn Uncertain significance Single submitter
- GABRG1 p.Asp411Glu Uncertain significance Single submitter
- GABRG1 p.Asp43Glu Uncertain significance Single submitter
- GABRG1 p.Gln405Leu Uncertain significance Single submitter
- GABRG1 p.Gly62Arg Uncertain significance Single submitter
- GABRG1 p.His383Arg Uncertain significance Single submitter
- GABRG1 p.Ile170Val Uncertain significance Single submitter
- GABRG1 p.Ile249Thr Uncertain significance Single submitter
- GABRG1 p.Ile319Val Uncertain significance Single submitter
- GABRG1 p.Ile394Thr Uncertain significance Single submitter
- GABRG1 p.Ile64Asn Uncertain significance Single submitter
- GABRG1 p.Ile64Val Uncertain significance Single submitter
- GABRG1 p.Ile90Val Uncertain significance Single submitter
- GABRG1 p.Leu124Phe Uncertain significance Single submitter
- GABRG1 p.Leu124Val Uncertain significance Single submitter
- GABRG1 p.Leu133Phe Uncertain significance Single submitter
- GABRG1 p.Leu13Ile Uncertain significance Single submitter
- GABRG1 p.Leu13Phe Uncertain significance Single submitter
- GABRG1 p.Leu316Gln Uncertain significance Single submitter
- GABRG1 p.Met197Val Uncertain significance Single submitter
- GABRG1 p.Met313Val Uncertain significance Single submitter
- GABRG1 p.Met333Ile Uncertain significance Single submitter
- GABRG1 p.Met391Val Uncertain significance Single submitter
- GABRG1 p.Pro397Leu Uncertain significance Single submitter
- GABRG1 p.Ser122Gly Uncertain significance Single submitter
- GABRG1 p.Ser377Leu Uncertain significance Single submitter
- GABRG1 p.Thr358Ile Uncertain significance Single submitter
- GABRG1 p.Thr365Ile Uncertain significance Single submitter
- GABRG1 p.Thr367Ala Uncertain significance Single submitter
- GABRG1 p.Thr48Ala Uncertain significance Single submitter
- GABRG1 p.Thr52Asn Uncertain significance Single submitter
- GABRG1 p.Tyr218Cys Uncertain significance Single submitter
- GABRG1 p.Val102Ile Uncertain significance Single submitter
- GABRG1 p.Val21Ala Uncertain significance Single submitter
- GABRG1 p.Val460Ile Uncertain significance Single submitter
-
GABRG1 p.Pro11Leu
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 14
The independent predictors disagree with each other — read with care.
- GABRG1 p.Asp157Ala Uncertain significance Single submitter
- GABRG1 p.Cys417Tyr Uncertain significance Single submitter
- GABRG1 p.Cys422Ser Uncertain significance Single submitter
- GABRG1 p.Gly409Cys Uncertain significance Single submitter
- GABRG1 p.Gly74Ser Uncertain significance Single submitter
- GABRG1 p.Ile114Asn Uncertain significance Single submitter
- GABRG1 p.Ile445Met Uncertain significance Single submitter
- GABRG1 p.Ile83Met Uncertain significance Single submitter
- GABRG1 p.Ile83Thr Uncertain significance Single submitter
- GABRG1 p.Pro212Ser Uncertain significance Single submitter
- GABRG1 p.Thr110Ala Uncertain significance Single submitter
- GABRG1 p.Thr118Ile Uncertain significance Single submitter
- GABRG1 p.Thr261Lys Uncertain significance Single submitter
- GABRG1 p.Thr353Ile Uncertain significance Single submitter
All GABRG1 variants
Benign/Likely benign 1
- p.Thr129= Multiple submitters
Uncertain significance 59
- p.Ala56Thr Single submitter ⚠
- p.Arg169Leu Single submitter ⚠
- p.Asn214Lys Single submitter ⚠
- p.Asn360Ser Single submitter ⚠
- p.Asn392Ser Single submitter ⚠
- p.Asp157Ala Single submitter ⚠
- p.Asp401Asn Single submitter ⚠
- p.Asp411Glu Single submitter ⚠
- p.Asp43Glu Single submitter ⚠
- p.Cys417Tyr Single submitter ⚠
- p.Cys422Ser Single submitter ⚠
- p.Gln405Leu Single submitter ⚠
- p.Gly409Cys Single submitter ⚠
- p.Gly62Arg Single submitter ⚠
- p.Gly74Ser Single submitter ⚠
- p.His383Arg Single submitter ⚠
- p.Ile114Asn Single submitter ⚠
- p.Ile143Leu Single submitter
- p.Ile161Val Single submitter
- p.Ile170Val Single submitter ⚠
- p.Ile249Thr Single submitter ⚠
- p.Ile319Val Single submitter ⚠
- p.Ile394Thr Single submitter ⚠
- p.Ile445Met Single submitter ⚠
- p.Ile64Asn Single submitter ⚠
- p.Ile64Val Single submitter ⚠
- p.Ile83Met Single submitter ⚠
- p.Ile83Thr Single submitter ⚠
- p.Ile90Val Single submitter ⚠
- p.Leu124Phe Single submitter ⚠
- p.Leu124Val Single submitter ⚠
- p.Leu133Phe Single submitter ⚠
- p.Leu13Ile Single submitter ⚠
- p.Leu13Phe Single submitter ⚠
- p.Leu316Gln Single submitter ⚠
- p.Lys58Glu Single submitter
- p.Met139Val Single submitter
- p.Met197Val Single submitter ⚠
- p.Met313Val Single submitter ⚠
- p.Met333Ile Single submitter ⚠
- p.Met391Val Single submitter ⚠
- p.Pro212Ser Single submitter ⚠
- p.Pro397Leu Single submitter ⚠
- p.Ser122Gly Single submitter ⚠
- p.Ser377Leu Single submitter ⚠
- p.Thr110Ala Single submitter ⚠
- p.Thr118Ile Single submitter ⚠
- p.Thr261Lys Single submitter ⚠
- p.Thr353Ile Single submitter ⚠
- p.Thr358Ile Single submitter ⚠
- p.Thr365Ile Single submitter ⚠
- p.Thr367Ala Single submitter ⚠
- p.Thr48Ala Single submitter ⚠
- p.Thr52Asn Single submitter ⚠
- p.Tyr218Cys Single submitter ⚠
- p.Val102Ile Single submitter ⚠
- p.Val21Ala Single submitter ⚠
- p.Val460Ile Single submitter ⚠
- p.Pro11Leu No assertion criteria prostate cancer ⚠