GABRP — 61 ClinVar variants
All ClinVar germline GABRP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Benign · 5 Likely benign · 55 Uncertain significance
Full GABRP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GABRP p.Asp376Asn Uncertain significance Multiple submitters
- GABRP p.Ala46Thr Uncertain significance Single submitter
- GABRP p.Arg110His Uncertain significance Single submitter
- GABRP p.Arg141Cys Uncertain significance Single submitter
- GABRP p.Arg206Gln Uncertain significance Single submitter
- GABRP p.Arg239Gln Uncertain significance Single submitter
- GABRP p.Arg396Gln Uncertain significance Single submitter
- GABRP p.Asn102Ser Uncertain significance Single submitter
- GABRP p.Asn161Ser Uncertain significance Single submitter
- GABRP p.Asn43Asp Uncertain significance Single submitter
- GABRP p.Asp197Asn Uncertain significance Single submitter
- GABRP p.Asp404Val Uncertain significance Single submitter
- GABRP p.Cys11Phe Uncertain significance Single submitter
- GABRP p.Cys174Arg Uncertain significance Single submitter
- GABRP p.Cys20Arg Uncertain significance Single submitter
- GABRP p.Gln22Arg Uncertain significance Single submitter
- GABRP p.Glu347Gly Uncertain significance Single submitter
- GABRP p.Glu397Lys Uncertain significance Single submitter
- GABRP p.Ile266Asn Uncertain significance Single submitter
- GABRP p.Ile371Asn Uncertain significance Single submitter
- GABRP p.Ile425Leu Uncertain significance Single submitter
- GABRP p.Leu193Val Uncertain significance Single submitter
- GABRP p.Leu234Phe Uncertain significance Single submitter
- GABRP p.Leu259Ser Uncertain significance Single submitter
- GABRP p.Lys398Glu Uncertain significance Single submitter
- GABRP p.Met162Val Uncertain significance Single submitter
- GABRP p.Met438Leu Uncertain significance Single submitter
- GABRP p.Phe41Ser Uncertain significance Single submitter
- GABRP p.Pro39Thr Uncertain significance Single submitter
- GABRP p.Ser260Cys Uncertain significance Single submitter
- GABRP p.Ser76Pro Uncertain significance Single submitter
- GABRP p.Thr171Ala Uncertain significance Single submitter
- GABRP p.Thr294Asn Uncertain significance Single submitter
- GABRP p.Thr66Ser Uncertain significance Single submitter
- GABRP p.Tyr250Cys Uncertain significance Single submitter
- GABRP p.Val251Ile Uncertain significance Single submitter
- GABRP p.Val262Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- GABRP p.Ala109Val Uncertain significance Single submitter
- GABRP p.Ala151Asp Uncertain significance Single submitter
- GABRP p.Arg206Trp Uncertain significance Single submitter
- GABRP p.Arg239Trp Uncertain significance Single submitter
- GABRP p.Asn430Ser Uncertain significance Single submitter
- GABRP p.Glu225Asp Uncertain significance Single submitter
- GABRP p.Ile72Met Uncertain significance Single submitter
- GABRP p.Phe129Ser Uncertain significance Single submitter
- GABRP p.Phe143Leu Uncertain significance Single submitter
- GABRP p.Thr147Met Uncertain significance Single submitter
- GABRP p.Thr294Pro Uncertain significance Single submitter
- GABRP p.Tyr210Cys Uncertain significance Single submitter
All GABRP variants
Benign 1
- p.Arg200His Single submitter
Likely benign 5
- p.Ala8Thr Single submitter
- p.Gly31Ser Single submitter
- p.Ser350Asn Single submitter
- p.Thr343Ile Single submitter
- p.Val349Ala Single submitter
Uncertain significance 55
- p.Asp376Asn Multiple submitters ⚠
- p.Ala109Val Single submitter ⚠
- p.Ala151Asp Single submitter ⚠
- p.Ala46Thr Single submitter ⚠
- p.Ala84Val Single submitter
- p.Arg110His Single submitter ⚠
- p.Arg141Cys Single submitter ⚠
- p.Arg206Gln Single submitter ⚠
- p.Arg206Trp Single submitter ⚠
- p.Arg239Gln Single submitter ⚠
- p.Arg239Trp Single submitter ⚠
- p.Arg396Gln Single submitter ⚠
- p.Asn102Ser Single submitter ⚠
- p.Asn161Ser Single submitter ⚠
- p.Asn196Lys Single submitter
- p.Asn430Ser Single submitter ⚠
- p.Asn43Asp Single submitter ⚠
- p.Asp197Asn Single submitter ⚠
- p.Asp404Val Single submitter ⚠
- p.Cys11Phe Single submitter ⚠
- p.Cys174Arg Single submitter ⚠
- p.Cys20Arg Single submitter ⚠
- p.Gln22Arg Single submitter ⚠
- p.Glu203fs Single submitter
- p.Glu225Asp Single submitter ⚠
- p.Glu347Gly Single submitter ⚠
- p.Glu397Lys Single submitter ⚠
- p.Gly136Glu Single submitter
- p.Ile266Asn Single submitter ⚠
- p.Ile371Asn Single submitter ⚠
- p.Ile425Leu Single submitter ⚠
- p.Ile72Met Single submitter ⚠
- p.Leu149Met Single submitter
- p.Leu193Val Single submitter ⚠
- p.Leu234Phe Single submitter ⚠
- p.Leu259Ser Single submitter ⚠
- p.Lys103Asn Single submitter
- p.Lys398Glu Single submitter ⚠
- p.Met162Val Single submitter ⚠
- p.Met438Leu Single submitter ⚠
- p.Phe129Ser Single submitter ⚠
- p.Phe143Leu Single submitter ⚠
- p.Phe41Ser Single submitter ⚠
- p.Pro39Thr Single submitter ⚠
- p.Ser260Cys Single submitter ⚠
- p.Ser76Pro Single submitter ⚠
- p.Thr147Met Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr294Asn Single submitter ⚠
- p.Thr294Pro Single submitter ⚠
- p.Thr66Ser Single submitter ⚠
- p.Tyr210Cys Single submitter ⚠
- p.Tyr250Cys Single submitter ⚠
- p.Val251Ile Single submitter ⚠
- p.Val262Ile Single submitter ⚠