GABRR3 — 90 ClinVar variants
All ClinVar germline GABRR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
7 Likely benign · 83 Uncertain significance
Full GABRR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GABRR3 p.Ala246Ser Uncertain significance Single submitter
- GABRR3 p.Ala319Thr Uncertain significance Single submitter
- GABRR3 p.Ala4Asp Uncertain significance Single submitter
- GABRR3 p.Ala73Ser Uncertain significance Single submitter
- GABRR3 p.Arg111Thr Uncertain significance Single submitter
- GABRR3 p.Arg360Gln Uncertain significance Single submitter
- GABRR3 p.Arg448Gly Uncertain significance Single submitter
- GABRR3 p.Arg47Ser Uncertain significance Single submitter
- GABRR3 p.Arg57Gln Uncertain significance Single submitter
- GABRR3 p.Arg57Leu Uncertain significance Single submitter
- GABRR3 p.Asn101Asp Uncertain significance Single submitter
- GABRR3 p.Asn260Lys Uncertain significance Single submitter
- GABRR3 p.Asp116Tyr Uncertain significance Single submitter
- GABRR3 p.Asp143Tyr Uncertain significance Single submitter
- GABRR3 p.Asp143Val Uncertain significance Single submitter
- GABRR3 p.Asp418Asn Uncertain significance Single submitter
- GABRR3 p.Asp69Asn Uncertain significance Single submitter
- GABRR3 p.Asp71Asn Uncertain significance Single submitter
- GABRR3 p.Cys22Ser Uncertain significance Single submitter
- GABRR3 p.Gln32Glu Uncertain significance Single submitter
- GABRR3 p.Gln40Pro Uncertain significance Single submitter
- GABRR3 p.Gln6Arg Uncertain significance Single submitter
- GABRR3 p.Glu117Lys Uncertain significance Single submitter
- GABRR3 p.Glu201Asp Uncertain significance Single submitter
- GABRR3 p.Gly244Arg Uncertain significance Single submitter
- GABRR3 p.Gly86Ala Uncertain significance Single submitter
- GABRR3 p.His155Arg Uncertain significance Single submitter
- GABRR3 p.His218Gln Uncertain significance Single submitter
- GABRR3 p.His441Asn Uncertain significance Single submitter
- GABRR3 p.Ile144Thr Uncertain significance Single submitter
- GABRR3 p.Ile27Thr Uncertain significance Single submitter
- GABRR3 p.Ile422Thr Uncertain significance Single submitter
- GABRR3 p.Ile435Asn Uncertain significance Single submitter
- GABRR3 p.Ile67Thr Uncertain significance Single submitter
- GABRR3 p.Ile87Met Uncertain significance Single submitter
- GABRR3 p.Leu17Met Uncertain significance Single submitter
- GABRR3 p.Leu202Gln Uncertain significance Single submitter
- GABRR3 p.Leu257Phe Uncertain significance Single submitter
- GABRR3 p.Leu263Pro Uncertain significance Single submitter
- GABRR3 p.Leu327Phe Uncertain significance Single submitter
- GABRR3 p.Lys28Thr Uncertain significance Single submitter
- GABRR3 p.Met163Val Uncertain significance Single submitter
- GABRR3 p.Met186Thr Uncertain significance Single submitter
- GABRR3 p.Met229Thr Uncertain significance Single submitter
- GABRR3 p.Met29Val Uncertain significance Single submitter
- GABRR3 p.Met394Ile Uncertain significance Single submitter
- GABRR3 p.Met74Ile Uncertain significance Single submitter
- GABRR3 p.Phe276Val Uncertain significance Single submitter
- GABRR3 p.Pro19Ser Uncertain significance Single submitter
- GABRR3 p.Ser285Pro Uncertain significance Single submitter
- GABRR3 p.Ser35Phe Uncertain significance Single submitter
- GABRR3 p.Thr195Ile Uncertain significance Single submitter
- GABRR3 p.Thr305Asn Uncertain significance Single submitter
- GABRR3 p.Thr305Ile Uncertain significance Single submitter
- GABRR3 p.Thr30Lys Uncertain significance Single submitter
- GABRR3 p.Trp335Leu Uncertain significance Single submitter
- GABRR3 p.Tyr61His Uncertain significance Single submitter
- GABRR3 p.Tyr61Phe Uncertain significance Single submitter
- GABRR3 p.Val166Ile Uncertain significance Single submitter
- GABRR3 p.Val166Leu Uncertain significance Single submitter
- GABRR3 p.Val180Phe Uncertain significance Single submitter
- GABRR3 p.Val262Glu Uncertain significance Single submitter
- GABRR3 p.Val467Leu Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- GABRR3 p.Arg165Cys Uncertain significance Single submitter
- GABRR3 p.Arg165His Uncertain significance Single submitter
- GABRR3 p.Arg294Ser Uncertain significance Single submitter
- GABRR3 p.Asn352Lys Uncertain significance Single submitter
- GABRR3 p.Asn459Ser Uncertain significance Single submitter
- GABRR3 p.Glu160Gly Uncertain significance Single submitter
- GABRR3 p.Glu92Asp Uncertain significance Single submitter
- GABRR3 p.Ile236Thr Uncertain significance Single submitter
- GABRR3 p.Leu257Val Uncertain significance Single submitter
- GABRR3 p.Phe153Leu Uncertain significance Single submitter
- GABRR3 p.Val172Leu Uncertain significance Single submitter
All GABRR3 variants
Likely benign 7
- p.Ala316Gly Single submitter
- p.Ala56Val Single submitter
- p.Arg371Gly Single submitter
- p.Arg57Trp Single submitter
- p.Met159Val Single submitter
- p.Phe5Ser Single submitter
- p.Val465Ile Single submitter
Uncertain significance 83
- p.Ala241Glu Single submitter
- p.Ala246Ser Single submitter ⚠
- p.Ala319Thr Single submitter ⚠
- p.Ala4Asp Single submitter ⚠
- p.Ala73Ser Single submitter ⚠
- p.Arg111Thr Single submitter ⚠
- p.Arg118Lys Single submitter
- p.Arg165Cys Single submitter ⚠
- p.Arg165His Single submitter ⚠
- p.Arg294Ile Single submitter
- p.Arg294Ser Single submitter ⚠
- p.Arg360Gln Single submitter ⚠
- p.Arg448Gly Single submitter ⚠
- p.Arg47Ser Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg57Leu Single submitter ⚠
- p.Asn101Asp Single submitter ⚠
- p.Asn260Lys Single submitter ⚠
- p.Asn352Lys Single submitter ⚠
- p.Asn459Ser Single submitter ⚠
- p.Asp116Tyr Single submitter ⚠
- p.Asp143Asn Single submitter
- p.Asp143Tyr Single submitter ⚠
- p.Asp143Val Single submitter ⚠
- p.Asp418Asn Single submitter ⚠
- p.Asp69Asn Single submitter ⚠
- p.Asp71Asn Single submitter ⚠
- p.Cys22Ser Single submitter ⚠
- p.Gln32Glu Single submitter ⚠
- p.Gln40Pro Single submitter ⚠
- p.Gln6Arg Single submitter ⚠
- p.Glu117Lys Single submitter ⚠
- p.Glu160Gly Single submitter ⚠
- p.Glu201Asp Single submitter ⚠
- p.Glu92Asp Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly86Ala Single submitter ⚠
- p.His155Arg Single submitter ⚠
- p.His218Gln Single submitter ⚠
- p.His441Asn Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile236Thr Single submitter ⚠
- p.Ile27Thr Single submitter ⚠
- p.Ile422Thr Single submitter ⚠
- p.Ile435Asn Single submitter ⚠
- p.Ile67Thr Single submitter ⚠
- p.Ile87Met Single submitter ⚠
- p.Leu17Met Single submitter ⚠
- p.Leu202Gln Single submitter ⚠
- p.Leu257Phe Single submitter ⚠
- p.Leu257Val Single submitter ⚠
- p.Leu263Pro Single submitter ⚠
- p.Leu327Phe Single submitter ⚠
- p.Lys28Thr Single submitter ⚠
- p.Met163Val Single submitter ⚠
- p.Met186Thr Single submitter ⚠
- p.Met229Thr Single submitter ⚠
- p.Met29Val Single submitter ⚠
- p.Met394Ile Single submitter ⚠
- p.Met74Ile Single submitter ⚠
- p.Phe153Leu Single submitter ⚠
- p.Phe276Val Single submitter ⚠
- p.Pro19Ser Single submitter ⚠
- p.Ser285Pro Single submitter ⚠
- p.Ser35Phe Single submitter ⚠
- p.Thr179Met Single submitter
- p.Thr195Ile Single submitter ⚠
- p.Thr305Asn Single submitter ⚠
- p.Thr305Ile Single submitter ⚠
- p.Thr30Lys Single submitter ⚠
- p.Trp335Leu Single submitter ⚠
- p.Tyr207Cys Single submitter
- p.Tyr455Cys Single submitter
- p.Tyr61His Single submitter ⚠
- p.Tyr61Phe Single submitter ⚠
- p.Val166Ile Single submitter ⚠
- p.Val166Leu Single submitter ⚠
- p.Val172Leu Single submitter ⚠
- p.Val180Phe Single submitter ⚠
- p.Val262Glu Single submitter ⚠
- p.Val324Leu Single submitter
- p.Val467Leu Single submitter ⚠
- p.Val83Ala Single submitter