Sugi Variant

Sugi Variant/GALM

GALM — 116 ClinVar variants

All ClinVar germline GALM variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →

5 Pathogenic · 1 Likely pathogenic · 1 Conflicting · 23 Benign · 1 Benign/Likely benign · 22 Likely benign · 63 Uncertain significance

Full GALM gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 57

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 1

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 41

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 15

The independent predictors disagree with each other — read with care.

All GALM variants

Pathogenic 5

Likely pathogenic 1

Conflicting classifications of pathogenicity 1

Benign 23

Benign/Likely benign 1

Likely benign 22

Uncertain significance 63