GALNT10 — 98 ClinVar variants
All ClinVar germline GALNT10 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 89 flagged for review →
1 Benign · 2 Benign/Likely benign · 3 Likely benign · 92 Uncertain significance
Full GALNT10 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 89
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 70
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GALNT10 p.Ala228Ser Uncertain significance Single submitter
- GALNT10 p.Ala280Ser Uncertain significance Single submitter
- GALNT10 p.Ala306Asp Uncertain significance Single submitter
- GALNT10 p.Ala402Thr Uncertain significance Single submitter
- GALNT10 p.Ala417Thr Uncertain significance Single submitter
- GALNT10 p.Ala45Gly Uncertain significance Single submitter
- GALNT10 p.Ala48Glu Uncertain significance Single submitter
- GALNT10 p.Ala48Thr Uncertain significance Single submitter
- GALNT10 p.Ala526Thr Uncertain significance Single submitter
- GALNT10 p.Arg139His Uncertain significance Single submitter
- GALNT10 p.Arg163Leu Uncertain significance Single submitter
- GALNT10 p.Arg214Gln Uncertain significance Single submitter
- GALNT10 p.Arg214Trp Uncertain significance Single submitter
- GALNT10 p.Arg256Gln Uncertain significance Single submitter
- GALNT10 p.Arg258His Uncertain significance Single submitter
- GALNT10 p.Arg285Gln Uncertain significance Single submitter
- GALNT10 p.Arg296Trp Uncertain significance Single submitter
- GALNT10 p.Arg34Gln Uncertain significance Single submitter
- GALNT10 p.Arg34Trp Uncertain significance Single submitter
- GALNT10 p.Arg359His Uncertain significance Single submitter
- GALNT10 p.Arg408His Uncertain significance Single submitter
- GALNT10 p.Arg427Cys Uncertain significance Single submitter
- GALNT10 p.Arg490Gln Uncertain significance Single submitter
- GALNT10 p.Arg490Pro Uncertain significance Single submitter
- GALNT10 p.Arg492His Uncertain significance Single submitter
- GALNT10 p.Arg512Gln Uncertain significance Single submitter
- GALNT10 p.Arg512Trp Uncertain significance Single submitter
- GALNT10 p.Arg550Leu Uncertain significance Single submitter
- GALNT10 p.Arg7Gln Uncertain significance Single submitter
- GALNT10 p.Arg81Gln Uncertain significance Single submitter
- GALNT10 p.Arg86Cys Uncertain significance Single submitter
- GALNT10 p.Asn170Ser Uncertain significance Single submitter
- GALNT10 p.Asn24Ser Uncertain significance Single submitter
- GALNT10 p.Asn579Ser Uncertain significance Single submitter
- GALNT10 p.Asn601Ser Uncertain significance Single submitter
- GALNT10 p.Asp100Asn Uncertain significance Single submitter
- GALNT10 p.Asp105Asn Uncertain significance Single submitter
- GALNT10 p.Asp184Ala Uncertain significance Single submitter
- GALNT10 p.Asp272Asn Uncertain significance Single submitter
- GALNT10 p.Asp73Ala Uncertain significance Single submitter
- GALNT10 p.Glu175Gln Uncertain significance Single submitter
- GALNT10 p.Glu291Asp Uncertain significance Single submitter
- GALNT10 p.Gly469Arg Uncertain significance Single submitter
- GALNT10 p.Gly52Ala Uncertain significance Single submitter
- GALNT10 p.Gly52Arg Uncertain significance Single submitter
- GALNT10 p.His557Tyr Uncertain significance Single submitter
- GALNT10 p.Ile269Thr Uncertain significance Single submitter
- GALNT10 p.Leu202Phe Uncertain significance Single submitter
- GALNT10 p.Leu251Pro Uncertain significance Single submitter
- GALNT10 p.Leu332Phe Uncertain significance Single submitter
- GALNT10 p.Leu546Met Uncertain significance Single submitter
- GALNT10 p.Lys448Arg Uncertain significance Single submitter
- GALNT10 p.Met398Arg Uncertain significance Single submitter
- GALNT10 p.Pro248Ser Uncertain significance Single submitter
- GALNT10 p.Pro364Leu Uncertain significance Single submitter
- GALNT10 p.Pro381Leu Uncertain significance Single submitter
- GALNT10 p.Pro97Ala Uncertain significance Single submitter
- GALNT10 p.Ser172Leu Uncertain significance Single submitter
- GALNT10 p.Ser350Ala Uncertain significance Single submitter
- GALNT10 p.Ser55Thr Uncertain significance Single submitter
- GALNT10 p.Thr474Ile Uncertain significance Single submitter
- GALNT10 p.Thr534Met Uncertain significance Single submitter
- GALNT10 p.Thr62Arg Uncertain significance Single submitter
- GALNT10 p.Trp460Cys Uncertain significance Single submitter
- GALNT10 p.Trp507Cys Uncertain significance Single submitter
- GALNT10 p.Trp74Ser Uncertain significance Single submitter
- GALNT10 p.Val117Ile Uncertain significance Single submitter
- GALNT10 p.Val165Ile Uncertain significance Single submitter
- GALNT10 p.Val177Leu Uncertain significance Single submitter
-
GALNT10 p.Tyr401Asp
Uncertain significance
No assertion criteria
GALNT10-related disorder
Predictors split 19
The independent predictors disagree with each other — read with care.
- GALNT10 p.Arg139Cys Uncertain significance Single submitter
- GALNT10 p.Arg189Gln Uncertain significance Single submitter
- GALNT10 p.Arg275Trp Uncertain significance Single submitter
- GALNT10 p.Arg413His Uncertain significance Single submitter
- GALNT10 p.Arg464Gln Likely benign Single submitter
- GALNT10 p.Arg550Cys Uncertain significance Single submitter
- GALNT10 p.Arg550Pro Uncertain significance Single submitter
- GALNT10 p.Asn257Lys Uncertain significance Single submitter
- GALNT10 p.Glu598Gly Uncertain significance Single submitter
- GALNT10 p.Gly383Arg Uncertain significance Single submitter
- GALNT10 p.Ile130Thr Uncertain significance Single submitter
- GALNT10 p.Met200Val Uncertain significance Single submitter
- GALNT10 p.Pro300Leu Uncertain significance Single submitter
- GALNT10 p.Pro456Leu Uncertain significance Single submitter
- GALNT10 p.Ser160Pro Uncertain significance Single submitter
- GALNT10 p.Ser540Arg Uncertain significance Single submitter
- GALNT10 p.Thr592Ala Uncertain significance Single submitter
- GALNT10 p.Thr99Ile Uncertain significance Single submitter
- GALNT10 p.Val453Met Uncertain significance Single submitter
All GALNT10 variants
Benign 1
- p.Lys542= Single submitter
Benign/Likely benign 2
- c.263-138A>T Multiple submitters
- c.263-139G>C Multiple submitters
Likely benign 3
- p.Arg464Gln Single submitter ⚠
- p.Val489Ile Single submitter
- p.Pro452= No assertion criteria GALNT10-related disorder
Uncertain significance 92
- p.Ala228Ser Single submitter ⚠
- p.Ala280Ser Single submitter ⚠
- p.Ala306Asp Single submitter ⚠
- p.Ala402Thr Single submitter ⚠
- p.Ala417Thr Single submitter ⚠
- p.Ala45Gly Single submitter ⚠
- p.Ala48Glu Single submitter ⚠
- p.Ala48Thr Single submitter ⚠
- p.Ala526Thr Single submitter ⚠
- p.Arg139Cys Single submitter ⚠
- p.Arg139His Single submitter ⚠
- p.Arg163Leu Single submitter ⚠
- p.Arg189Gln Single submitter ⚠
- p.Arg214Gln Single submitter ⚠
- p.Arg214Trp Single submitter ⚠
- p.Arg256Gln Single submitter ⚠
- p.Arg258His Single submitter ⚠
- p.Arg275Trp Single submitter ⚠
- p.Arg285Gln Single submitter ⚠
- p.Arg296Trp Single submitter ⚠
- p.Arg34Gln Single submitter ⚠
- p.Arg34Trp Single submitter ⚠
- p.Arg359His Single submitter ⚠
- p.Arg408His Single submitter ⚠
- p.Arg409Gln Single submitter
- p.Arg413His Single submitter ⚠
- p.Arg427Cys Single submitter ⚠
- p.Arg490Gln Single submitter ⚠
- p.Arg490Pro Single submitter ⚠
- p.Arg492His Single submitter ⚠
- p.Arg512Gln Single submitter ⚠
- p.Arg512Trp Single submitter ⚠
- p.Arg550Cys Single submitter ⚠
- p.Arg550Leu Single submitter ⚠
- p.Arg550Pro Single submitter ⚠
- p.Arg7Gln Single submitter ⚠
- p.Arg81Gln Single submitter ⚠
- p.Arg86Cys Single submitter ⚠
- p.Asn170Ser Single submitter ⚠
- p.Asn24Ser Single submitter ⚠
- p.Asn257Lys Single submitter ⚠
- p.Asn579Ser Single submitter ⚠
- p.Asn601Ser Single submitter ⚠
- p.Asp100Asn Single submitter ⚠
- p.Asp105Asn Single submitter ⚠
- p.Asp184Ala Single submitter ⚠
- p.Asp272Asn Single submitter ⚠
- p.Asp73Ala Single submitter ⚠
- p.Gln585Glu Single submitter
- p.Glu175Gln Single submitter ⚠
- p.Glu291Asp Single submitter ⚠
- p.Glu598Gly Single submitter ⚠
- p.Gly383Arg Single submitter ⚠
- p.Gly469Arg Single submitter ⚠
- p.Gly52Ala Single submitter ⚠
- p.Gly52Arg Single submitter ⚠
- p.His557Tyr Single submitter ⚠
- p.Ile130Thr Single submitter ⚠
- p.Ile269Thr Single submitter ⚠
- p.Leu202Phe Single submitter ⚠
- p.Leu251Pro Single submitter ⚠
- p.Leu30Pro Single submitter
- p.Leu332Phe Single submitter ⚠
- p.Leu546Met Single submitter ⚠
- p.Lys448Arg Single submitter ⚠
- p.Met200Val Single submitter ⚠
- p.Met398Arg Single submitter ⚠
- p.Pro248Ser Single submitter ⚠
- p.Pro298Leu Single submitter
- p.Pro300Leu Single submitter ⚠
- p.Pro364Leu Single submitter ⚠
- p.Pro381Leu Single submitter ⚠
- p.Pro456Leu Single submitter ⚠
- p.Pro97Ala Single submitter ⚠
- p.Ser160Pro Single submitter ⚠
- p.Ser172Leu Single submitter ⚠
- p.Ser350Ala Single submitter ⚠
- p.Ser540Arg Single submitter ⚠
- p.Ser55Thr Single submitter ⚠
- p.Thr474Ile Single submitter ⚠
- p.Thr534Met Single submitter ⚠
- p.Thr592Ala Single submitter ⚠
- p.Thr62Arg Single submitter ⚠
- p.Thr99Ile Single submitter ⚠
- p.Trp460Cys Single submitter ⚠
- p.Trp507Cys Single submitter ⚠
- p.Trp74Ser Single submitter ⚠
- p.Val117Ile Single submitter ⚠
- p.Val165Ile Single submitter ⚠
- p.Val177Leu Single submitter ⚠
- p.Val453Met Single submitter ⚠
- p.Tyr401Asp No assertion criteria GALNT10-related disorder ⚠