GALR1 — 58 ClinVar variants
All ClinVar germline GALR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Likely benign · 57 Uncertain significance
Full GALR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 43
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GALR1 p.Ala127Gly Uncertain significance Single submitter
- GALR1 p.Ala171Val Uncertain significance Single submitter
- GALR1 p.Ala199Ser Uncertain significance Single submitter
- GALR1 p.Ala20Val Uncertain significance Single submitter
- GALR1 p.Arg141Leu Uncertain significance Single submitter
- GALR1 p.Arg150Gly Uncertain significance Single submitter
- GALR1 p.Arg323Cys Uncertain significance Single submitter
- GALR1 p.Arg323His Uncertain significance Single submitter
- GALR1 p.Arg60Leu Uncertain significance Single submitter
- GALR1 p.Asn12Ser Uncertain significance Single submitter
- GALR1 p.Gln190Arg Uncertain significance Single submitter
- GALR1 p.Glu2Gln Uncertain significance Single submitter
- GALR1 p.Gly11Asp Uncertain significance Single submitter
- GALR1 p.Gly11Ser Uncertain significance Single submitter
- GALR1 p.Gly41Cys Uncertain significance Single submitter
- GALR1 p.Gly6Arg Uncertain significance Single submitter
- GALR1 p.Gly6Trp Uncertain significance Single submitter
- GALR1 p.His267Pro Uncertain significance Single submitter
- GALR1 p.His348Gln Uncertain significance Single submitter
- GALR1 p.Ile159Asn Uncertain significance Single submitter
- GALR1 p.Leu146Phe Uncertain significance Single submitter
- GALR1 p.Leu3Arg Uncertain significance Single submitter
- GALR1 p.Leu77Arg Uncertain significance Single submitter
- GALR1 p.Leu8Phe Uncertain significance Single submitter
- GALR1 p.Lys197Arg Uncertain significance Single submitter
- GALR1 p.Lys242Arg Uncertain significance Single submitter
- GALR1 p.Pro16Gln Uncertain significance Single submitter
- GALR1 p.Pro16Leu Uncertain significance Single submitter
- GALR1 p.Pro16Ser Uncertain significance Single submitter
- GALR1 p.Pro18Ser Uncertain significance Single submitter
- GALR1 p.Pro194Ser Uncertain significance Single submitter
- GALR1 p.Ser122Asn Uncertain significance Single submitter
- GALR1 p.Ser145Tyr Uncertain significance Single submitter
- GALR1 p.Ser281Ala Uncertain significance Single submitter
- GALR1 p.Ser68Thr Uncertain significance Single submitter
- GALR1 p.Thr70Asn Uncertain significance Single submitter
- GALR1 p.Trp191Gly Uncertain significance Single submitter
- GALR1 p.Val102Met Uncertain significance Single submitter
- GALR1 p.Val156Met Uncertain significance Single submitter
- GALR1 p.Val298Met Uncertain significance Single submitter
- GALR1 p.Val39Met Uncertain significance Single submitter
- GALR1 p.Val54Ala Uncertain significance Single submitter
- GALR1 p.Val5Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GALR1 p.Ala80Thr Uncertain significance Single submitter
- GALR1 p.Arg150Cys Uncertain significance Single submitter
- GALR1 p.Asn12Lys Uncertain significance Single submitter
- GALR1 p.Glu271Ala Uncertain significance Single submitter
- GALR1 p.Gly41Asp Uncertain significance Single submitter
- GALR1 p.Thr185Asn Uncertain significance Single submitter
- GALR1 p.Thr245Ile Uncertain significance Single submitter
- GALR1 p.Trp188Arg Uncertain significance Single submitter
- GALR1 p.Tyr220Cys Uncertain significance Single submitter
- GALR1 p.Val253Ala Uncertain significance Single submitter
All GALR1 variants
Likely benign 1
- p.Arg142= Single submitter
Uncertain significance 57
- p.Ala127Gly Single submitter ⚠
- p.Ala152Thr Single submitter
- p.Ala171Val Single submitter ⚠
- p.Ala199Ser Single submitter ⚠
- p.Ala20Val Single submitter ⚠
- p.Ala80Ser Single submitter
- p.Ala80Thr Single submitter ⚠
- p.Arg141Leu Single submitter ⚠
- p.Arg150Cys Single submitter ⚠
- p.Arg150Gly Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg323His Single submitter ⚠
- p.Arg60Leu Single submitter ⚠
- p.Asn12Lys Single submitter ⚠
- p.Asn12Ser Single submitter ⚠
- p.Cys320Tyr Single submitter
- p.Gln190Arg Single submitter ⚠
- p.Glu271Ala Single submitter ⚠
- p.Glu2Gln Single submitter ⚠
- p.Gly11Asp Single submitter ⚠
- p.Gly11Ser Single submitter ⚠
- p.Gly41Asp Single submitter ⚠
- p.Gly41Cys Single submitter ⚠
- p.Gly6Arg Single submitter ⚠
- p.Gly6Trp Single submitter ⚠
- p.His173Gln Single submitter
- p.His267Pro Single submitter ⚠
- p.His348Gln Single submitter ⚠
- p.Ile159Asn Single submitter ⚠
- p.Leu146Phe Single submitter ⚠
- p.Leu3Arg Single submitter ⚠
- p.Leu77Arg Single submitter ⚠
- p.Leu8Phe Single submitter ⚠
- p.Lys197Arg Single submitter ⚠
- p.Lys242Arg Single submitter ⚠
- p.Pro16Gln Single submitter ⚠
- p.Pro16Leu Single submitter ⚠
- p.Pro16Ser Single submitter ⚠
- p.Pro18Ser Single submitter ⚠
- p.Pro194Ser Single submitter ⚠
- p.Ser122Asn Single submitter ⚠
- p.Ser145Tyr Single submitter ⚠
- p.Ser281Ala Single submitter ⚠
- p.Ser68Thr Single submitter ⚠
- p.Thr185Asn Single submitter ⚠
- p.Thr245Ile Single submitter ⚠
- p.Thr70Asn Single submitter ⚠
- p.Trp188Arg Single submitter ⚠
- p.Trp191Gly Single submitter ⚠
- p.Tyr220Cys Single submitter ⚠
- p.Val102Met Single submitter ⚠
- p.Val156Met Single submitter ⚠
- p.Val253Ala Single submitter ⚠
- p.Val298Met Single submitter ⚠
- p.Val39Met Single submitter ⚠
- p.Val54Ala Single submitter ⚠
- p.Val5Ile Single submitter ⚠