GALR2 — 71 ClinVar variants
All ClinVar germline GALR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 60 flagged for review →
2 Benign · 6 Likely benign · 63 Uncertain significance
Full GALR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 60
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GALR2 p.Ala208Thr Uncertain significance Single submitter
- GALR2 p.Ala308Ser Uncertain significance Single submitter
- GALR2 p.Ala325Gly Uncertain significance Single submitter
- GALR2 p.Ala358Pro Uncertain significance Single submitter
- GALR2 p.Arg140Gly Uncertain significance Single submitter
- GALR2 p.Arg183His Uncertain significance Single submitter
- GALR2 p.Arg209His Uncertain significance Single submitter
- GALR2 p.Arg212His Uncertain significance Single submitter
- GALR2 p.Arg212Ser Uncertain significance Single submitter
- GALR2 p.Arg216His Uncertain significance Single submitter
- GALR2 p.Arg274His Uncertain significance Single submitter
- GALR2 p.Arg313Gly Uncertain significance Single submitter
- GALR2 p.Asn171Lys Uncertain significance Single submitter
- GALR2 p.Asn43His Uncertain significance Single submitter
- GALR2 p.Asn66Tyr Uncertain significance Single submitter
- GALR2 p.Asp219Glu Uncertain significance Single submitter
- GALR2 p.Asp71His Uncertain significance Single submitter
- GALR2 p.Gln373His Uncertain significance Single submitter
- GALR2 p.Glu135Gly Uncertain significance Single submitter
- GALR2 p.Glu338Asp Uncertain significance Single submitter
- GALR2 p.Gly204Ala Uncertain significance Single submitter
- GALR2 p.His110Asn Uncertain significance Single submitter
- GALR2 p.His110Gln Uncertain significance Single submitter
- GALR2 p.Ile240Thr Uncertain significance Single submitter
- GALR2 p.Ile256Val Uncertain significance Single submitter
- GALR2 p.Ile27Met Uncertain significance Single submitter
- GALR2 p.Ile306Phe Uncertain significance Single submitter
- GALR2 p.Ile35Thr Uncertain significance Single submitter
- GALR2 p.Leu197Pro Uncertain significance Single submitter
- GALR2 p.Leu198Ile Uncertain significance Single submitter
- GALR2 p.Leu50Arg Uncertain significance Single submitter
- GALR2 p.Leu62Met Uncertain significance Single submitter
- GALR2 p.Leu72Met Uncertain significance Single submitter
- GALR2 p.Met345Arg Uncertain significance Single submitter
- GALR2 p.Phe36Leu Uncertain significance Single submitter
- GALR2 p.Pro370Ser Uncertain significance Single submitter
- GALR2 p.Pro80Leu Uncertain significance Single submitter
- GALR2 p.Ser153Pro Uncertain significance Single submitter
- GALR2 p.Ser281Phe Uncertain significance Single submitter
- GALR2 p.Ser331Arg Uncertain significance Single submitter
- GALR2 p.Ser380Thr Uncertain significance Single submitter
- GALR2 p.Ser4Pro Uncertain significance Single submitter
- GALR2 p.Thr305Ala Uncertain significance Single submitter
- GALR2 p.Val221Leu Uncertain significance Single submitter
- GALR2 p.Val280Leu Uncertain significance Single submitter
- GALR2 p.Val3Ile Uncertain significance Single submitter
- GALR2 p.Val46Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- GALR2 p.Ala118Thr Uncertain significance Single submitter
- GALR2 p.Ala243Glu Uncertain significance Single submitter
- GALR2 p.Arg128Ser Uncertain significance Single submitter
- GALR2 p.Arg229Cys Uncertain significance Single submitter
- GALR2 p.Gly312Ala Uncertain significance Single submitter
- GALR2 p.Ile85Thr Uncertain significance Single submitter
- GALR2 p.Leu211Ser Uncertain significance Single submitter
- GALR2 p.Leu97Pro Uncertain significance Single submitter
- GALR2 p.Phe264Leu Uncertain significance Single submitter
- GALR2 p.Phe32Leu Uncertain significance Single submitter
- GALR2 p.Ser195Asn Uncertain significance Single submitter
- GALR2 p.Ser4Leu Uncertain significance Single submitter
- GALR2 p.Val241Leu Uncertain significance Single submitter
All GALR2 variants
Benign 2
- p.Glu336Ala Multiple submitters
- p.Gly226Ser Multiple submitters
Likely benign 6
- p.Trp249Leu Multiple submitters
- p.Ala117= Single submitter
- p.Ala15Val Single submitter
- p.Ala324Val Single submitter
- p.Arg353Cys Single submitter
- p.Arg353His Single submitter
Uncertain significance 63
- p.Ala118Thr Single submitter ⚠
- p.Ala208Thr Single submitter ⚠
- p.Ala243Glu Single submitter ⚠
- p.Ala308Ser Single submitter ⚠
- p.Ala325Gly Single submitter ⚠
- p.Ala358Pro Single submitter ⚠
- p.Arg128Ser Single submitter ⚠
- p.Arg134Cys Single submitter
- p.Arg140Gly Single submitter ⚠
- p.Arg183His Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg212His Single submitter ⚠
- p.Arg212Ser Single submitter ⚠
- p.Arg216His Single submitter ⚠
- p.Arg229Cys Single submitter ⚠
- p.Arg274His Single submitter ⚠
- p.Arg313Gly Single submitter ⚠
- p.Asn171Lys Single submitter ⚠
- p.Asn43His Single submitter ⚠
- p.Asn66Tyr Single submitter ⚠
- p.Asp219Glu Single submitter ⚠
- p.Asp71His Single submitter ⚠
- p.Gln373His Single submitter ⚠
- p.Glu135Gly Single submitter ⚠
- p.Glu338Asp Single submitter ⚠
- p.Gly204Ala Single submitter ⚠
- p.Gly312Ala Single submitter ⚠
- p.His110Asn Single submitter ⚠
- p.His110Gln Single submitter ⚠
- p.Ile240Thr Single submitter ⚠
- p.Ile256Val Single submitter ⚠
- p.Ile27Met Single submitter ⚠
- p.Ile306Phe Single submitter ⚠
- p.Ile35Thr Single submitter ⚠
- p.Ile85Thr Single submitter ⚠
- p.Leu197Pro Single submitter ⚠
- p.Leu198Ile Single submitter ⚠
- p.Leu211Ser Single submitter ⚠
- p.Leu294Arg Single submitter
- p.Leu50Arg Single submitter ⚠
- p.Leu62Met Single submitter ⚠
- p.Leu72Met Single submitter ⚠
- p.Leu97Pro Single submitter ⚠
- p.Met345Arg Single submitter ⚠
- p.Phe264Leu Single submitter ⚠
- p.Phe32Leu Single submitter ⚠
- p.Phe36Leu Single submitter ⚠
- p.Pro370Ser Single submitter ⚠
- p.Pro80Leu Single submitter ⚠
- p.Ser153Pro Single submitter ⚠
- p.Ser195Asn Single submitter ⚠
- p.Ser281Phe Single submitter ⚠
- p.Ser331Arg Single submitter ⚠
- p.Ser380Thr Single submitter ⚠
- p.Ser4Leu Single submitter ⚠
- p.Ser4Pro Single submitter ⚠
- p.Thr305Ala Single submitter ⚠
- p.Val221Leu Single submitter ⚠
- p.Val241Leu Single submitter ⚠
- p.Val280Leu Single submitter ⚠
- p.Val291Ala Single submitter
- p.Val3Ile Single submitter ⚠
- p.Val46Met Single submitter ⚠