GALR3 — 68 ClinVar variants
All ClinVar germline GALR3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 63 flagged for review →
3 Likely benign · 65 Uncertain significance
Full GALR3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 63
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 50
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GALR3 p.Ala132Val Uncertain significance Single submitter
- GALR3 p.Ala179Gly Uncertain significance Single submitter
- GALR3 p.Ala220Val Uncertain significance Single submitter
- GALR3 p.Ala223Gly Uncertain significance Single submitter
- GALR3 p.Ala225Glu Uncertain significance Single submitter
- GALR3 p.Ala233Pro Uncertain significance Single submitter
- GALR3 p.Ala268Thr Uncertain significance Single submitter
- GALR3 p.Ala292Gly Uncertain significance Single submitter
- GALR3 p.Ala300Ser Uncertain significance Single submitter
- GALR3 p.Ala316Gly Uncertain significance Single submitter
- GALR3 p.Ala326Val Uncertain significance Single submitter
- GALR3 p.Arg228Lys Uncertain significance Single submitter
- GALR3 p.Arg262Pro Uncertain significance Single submitter
- GALR3 p.Arg318Ser Uncertain significance Single submitter
- GALR3 p.Arg324Cys Uncertain significance Single submitter
- GALR3 p.Arg342Lys Uncertain significance Single submitter
- GALR3 p.Asp10Asn Uncertain significance Single submitter
- GALR3 p.Cys285Tyr Uncertain significance Single submitter
- GALR3 p.Cys70Tyr Uncertain significance Single submitter
- GALR3 p.Gln44Lys Uncertain significance Single submitter
- GALR3 p.Glu177Gln Uncertain significance Single submitter
- GALR3 p.Glu355Ala Uncertain significance Single submitter
- GALR3 p.Gly13Arg Uncertain significance Single submitter
- GALR3 p.Gly205Arg Uncertain significance Single submitter
- GALR3 p.Gly216Arg Uncertain significance Single submitter
- GALR3 p.Gly249Asp Uncertain significance Single submitter
- GALR3 p.Gly335Ala Uncertain significance Single submitter
- GALR3 p.Gly347Val Uncertain significance Single submitter
- GALR3 p.Gly54Asp Uncertain significance Single submitter
- GALR3 p.Leu100Val Uncertain significance Single submitter
- GALR3 p.Leu246Phe Uncertain significance Single submitter
- GALR3 p.Leu254Ile Uncertain significance Single submitter
- GALR3 p.Leu69Phe Uncertain significance Single submitter
- GALR3 p.Leu93Val Uncertain significance Single submitter
- GALR3 p.Met237Val Uncertain significance Single submitter
- GALR3 p.Phe258Cys Uncertain significance Single submitter
- GALR3 p.Pro353Leu Uncertain significance Single submitter
- GALR3 p.Pro357Ala Uncertain significance Single submitter
- GALR3 p.Pro45Ala Uncertain significance Single submitter
- GALR3 p.Pro47Leu Uncertain significance Single submitter
- GALR3 p.Thr84Met Uncertain significance Single submitter
- GALR3 p.Trp248Cys Uncertain significance Single submitter
- GALR3 p.Tyr281Asp Uncertain significance Single submitter
- GALR3 p.Tyr291Cys Uncertain significance Single submitter
- GALR3 p.Val124Met Uncertain significance Single submitter
- GALR3 p.Val15Met Uncertain significance Single submitter
- GALR3 p.Val164Met Uncertain significance Single submitter
- GALR3 p.Val18Met Uncertain significance Single submitter
- GALR3 p.Val20Leu Uncertain significance Single submitter
- GALR3 p.Val41Met Uncertain significance Single submitter
Predictors split 13
The independent predictors disagree with each other — read with care.
- GALR3 p.Ala236Pro Uncertain significance Single submitter
- GALR3 p.Ala245Pro Uncertain significance Single submitter
- GALR3 p.Arg131His Uncertain significance Single submitter
- GALR3 p.Arg322His Uncertain significance Single submitter
- GALR3 p.Asn138Lys Uncertain significance Single submitter
- GALR3 p.Leu133Pro Uncertain significance Single submitter
- GALR3 p.Phe189Leu Uncertain significance Single submitter
- GALR3 p.Ser154Leu Uncertain significance Single submitter
- GALR3 p.Ser8Leu Uncertain significance Single submitter
- GALR3 p.Thr163Ile Uncertain significance Single submitter
- GALR3 p.Thr57Met Uncertain significance Single submitter
- GALR3 p.Tyr161Cys Uncertain significance Single submitter
- GALR3 p.Tyr166Cys Uncertain significance Single submitter
All GALR3 variants
Likely benign 3
- p.Ala221Val Single submitter
- p.Ala319Thr Single submitter
- p.Pro53Ala Single submitter
Uncertain significance 65
- p.Ala132Val Single submitter ⚠
- p.Ala179Gly Single submitter ⚠
- p.Ala220Val Single submitter ⚠
- p.Ala223Gly Single submitter ⚠
- p.Ala225Glu Single submitter ⚠
- p.Ala233Pro Single submitter ⚠
- p.Ala236Pro Single submitter ⚠
- p.Ala245Pro Single submitter ⚠
- p.Ala268Thr Single submitter ⚠
- p.Ala292Gly Single submitter ⚠
- p.Ala300Ser Single submitter ⚠
- p.Ala316Gly Single submitter ⚠
- p.Ala326Val Single submitter ⚠
- p.Arg131His Single submitter ⚠
- p.Arg228Lys Single submitter ⚠
- p.Arg262Pro Single submitter ⚠
- p.Arg318Ser Single submitter ⚠
- p.Arg322His Single submitter ⚠
- p.Arg324Cys Single submitter ⚠
- p.Arg342Lys Single submitter ⚠
- p.Asn138Lys Single submitter ⚠
- p.Asp10Asn Single submitter ⚠
- p.Cys285Tyr Single submitter ⚠
- p.Cys70Tyr Single submitter ⚠
- p.Gln44Lys Single submitter ⚠
- p.Glu177Gln Single submitter ⚠
- p.Glu355Ala Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly205Arg Single submitter ⚠
- p.Gly216Arg Single submitter ⚠
- p.Gly249Asp Single submitter ⚠
- p.Gly335Ala Single submitter ⚠
- p.Gly347Val Single submitter ⚠
- p.Gly54Asp Single submitter ⚠
- p.Leu100Val Single submitter ⚠
- p.Leu133Pro Single submitter ⚠
- p.Leu246Phe Single submitter ⚠
- p.Leu254Ile Single submitter ⚠
- p.Leu69Phe Single submitter ⚠
- p.Leu93Val Single submitter ⚠
- p.Met237Val Single submitter ⚠
- p.Phe189Leu Single submitter ⚠
- p.Phe258Cys Single submitter ⚠
- p.Pro217Leu Single submitter
- p.Pro353Leu Single submitter ⚠
- p.Pro357Ala Single submitter ⚠
- p.Pro45Ala Single submitter ⚠
- p.Pro47Leu Single submitter ⚠
- p.Ser154Leu Single submitter ⚠
- p.Ser8Leu Single submitter ⚠
- p.Thr135Met Single submitter
- p.Thr163Ile Single submitter ⚠
- p.Thr57Met Single submitter ⚠
- p.Thr84Met Single submitter ⚠
- p.Trp248Cys Single submitter ⚠
- p.Tyr161Cys Single submitter ⚠
- p.Tyr166Cys Single submitter ⚠
- p.Tyr281Asp Single submitter ⚠
- p.Tyr291Cys Single submitter ⚠
- p.Val124Met Single submitter ⚠
- p.Val15Met Single submitter ⚠
- p.Val164Met Single submitter ⚠
- p.Val18Met Single submitter ⚠
- p.Val20Leu Single submitter ⚠
- p.Val41Met Single submitter ⚠