GANC — 112 ClinVar variants
All ClinVar germline GANC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 104 flagged for review →
2 Benign · 6 Likely benign · 104 Uncertain significance
Full GANC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 104
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 74
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GANC p.Ala136Thr Uncertain significance Single submitter
- GANC p.Ala553Thr Uncertain significance Single submitter
- GANC p.Arg369Cys Uncertain significance Single submitter
- GANC p.Arg369His Uncertain significance Single submitter
- GANC p.Arg430His Uncertain significance Single submitter
- GANC p.Arg559Pro Uncertain significance Single submitter
- GANC p.Arg565Ser Uncertain significance Single submitter
- GANC p.Arg631His Uncertain significance Single submitter
- GANC p.Arg673Cys Uncertain significance Single submitter
- GANC p.Arg800Trp Uncertain significance Single submitter
- GANC p.Arg912Cys Uncertain significance Single submitter
- GANC p.Asn137Lys Uncertain significance Single submitter
- GANC p.Asn513Lys Uncertain significance Single submitter
- GANC p.Asn534Ser Uncertain significance Single submitter
- GANC p.Asn63Ser Uncertain significance Single submitter
- GANC p.Asp252His Uncertain significance Single submitter
- GANC p.Asp374Glu Uncertain significance Single submitter
- GANC p.Asp55Glu Uncertain significance Single submitter
- GANC p.Gln35His Uncertain significance Single submitter
- GANC p.Gln455Arg Uncertain significance Single submitter
- GANC p.Gln826His Uncertain significance Single submitter
- GANC p.Glu187Lys Uncertain significance Single submitter
- GANC p.Glu297Ala Uncertain significance Single submitter
- GANC p.Glu539Ala Uncertain significance Single submitter
- GANC p.Glu7Lys Uncertain significance Single submitter
- GANC p.Glu812Asp Uncertain significance Single submitter
- GANC p.Glu89Gly Uncertain significance Single submitter
- GANC p.Gly775Val Uncertain significance Single submitter
- GANC p.Gly790Val Uncertain significance Single submitter
- GANC p.Gly807Ala Uncertain significance Single submitter
- GANC p.His133Arg Uncertain significance Single submitter
- GANC p.His231Arg Uncertain significance Single submitter
- GANC p.His231Gln Uncertain significance Single submitter
- GANC p.Ile122Met Uncertain significance Single submitter
- GANC p.Ile134Leu Uncertain significance Single submitter
- GANC p.Ile151Phe Uncertain significance Single submitter
- GANC p.Ile442Thr Uncertain significance Single submitter
- GANC p.Ile505Thr Uncertain significance Single submitter
- GANC p.Ile599Val Uncertain significance Single submitter
- GANC p.Ile666Thr Uncertain significance Single submitter
- GANC p.Ile762Thr Uncertain significance Single submitter
- GANC p.Ile779Thr Uncertain significance Single submitter
- GANC p.Ile77Thr Uncertain significance Single submitter
- GANC p.Ile86Thr Uncertain significance Single submitter
- GANC p.Ile895Val Uncertain significance Single submitter
- GANC p.Leu121Val Uncertain significance Single submitter
- GANC p.Leu156Pro Uncertain significance Single submitter
- GANC p.Leu425Arg Uncertain significance Single submitter
- GANC p.Leu425Ile Uncertain significance Single submitter
- GANC p.Leu46Val Uncertain significance Single submitter
- GANC p.Leu815Phe Uncertain significance Single submitter
- GANC p.Lys707Arg Uncertain significance Single submitter
- GANC p.Lys749Asn Uncertain significance Single submitter
- GANC p.Lys833Gln Uncertain significance Single submitter
- GANC p.Met262Ile Uncertain significance Single submitter
- GANC p.Met307Thr Uncertain significance Single submitter
- GANC p.Met711Thr Uncertain significance Single submitter
- GANC p.Phe481Ser Uncertain significance Single submitter
- GANC p.Pro418Leu Uncertain significance Single submitter
- GANC p.Pro739Ser Uncertain significance Single submitter
- GANC p.Ser427Thr Uncertain significance Single submitter
- GANC p.Ser777Asn Uncertain significance Single submitter
- GANC p.Ser838Cys Uncertain significance Single submitter
- GANC p.Thr647Asn Uncertain significance Single submitter
- GANC p.Thr732Ile Uncertain significance Single submitter
- GANC p.Thr733Ala Uncertain significance Single submitter
- GANC p.Trp656Cys Uncertain significance Single submitter
- GANC p.Trp699Cys Uncertain significance Single submitter
- GANC p.Tyr392Phe Uncertain significance Single submitter
- GANC p.Tyr685His Uncertain significance Single submitter
- GANC p.Tyr75Cys Uncertain significance Single submitter
- GANC p.Val203Met Uncertain significance Single submitter
- GANC p.Val300Ile Uncertain significance Single submitter
- GANC p.Val470Met Uncertain significance Single submitter
Predictors split 30
The independent predictors disagree with each other — read with care.
- GANC p.Ala731Thr Uncertain significance Single submitter
- GANC p.Arg32His Uncertain significance Single submitter
- GANC p.Arg631Cys Uncertain significance Single submitter
- GANC p.Arg774Gln Uncertain significance Single submitter
- GANC p.Asn534Ile Uncertain significance Single submitter
- GANC p.Glu468Gly Uncertain significance Single submitter
- GANC p.Glu468Val Uncertain significance Single submitter
- GANC p.Glu564Gly Uncertain significance Single submitter
- GANC p.Gly562Glu Uncertain significance Single submitter
- GANC p.Gly659Ala Uncertain significance Single submitter
- GANC p.Ile331Thr Uncertain significance Single submitter
- GANC p.Ile617Met Uncertain significance Single submitter
- GANC p.Ile74Met Uncertain significance Single submitter
- GANC p.Leu556Met Uncertain significance Single submitter
- GANC p.Leu657Arg Uncertain significance Single submitter
- GANC p.Leu901Phe Uncertain significance Single submitter
- GANC p.Lys527Arg Uncertain significance Single submitter
- GANC p.Met792Val Uncertain significance Single submitter
- GANC p.Pro640Ser Uncertain significance Single submitter
- GANC p.Pro770Ser Uncertain significance Single submitter
- GANC p.Ser606Thr Uncertain significance Single submitter
- GANC p.Ser611Cys Uncertain significance Single submitter
- GANC p.Thr750Ile Uncertain significance Single submitter
- GANC p.Thr893Ile Uncertain significance Single submitter
- GANC p.Tyr254Cys Uncertain significance Single submitter
- GANC p.Tyr259Cys Uncertain significance Single submitter
- GANC p.Tyr446Cys Uncertain significance Single submitter
- GANC p.Val486Ile Uncertain significance Single submitter
- GANC p.Val778Met Uncertain significance Single submitter
- GANC p.Val873Met Uncertain significance Single submitter
All GANC variants
Benign 2
- p.Glu88Lys Multiple submitters
- p.Ile166Val Multiple submitters
Likely benign 6
- c.1741+7A>G Single submitter
- p.Asp129Gly Single submitter
- p.Glu660Lys Single submitter
- p.Thr42Ala Single submitter
- p.Thr626Ala Single submitter
- p.Tyr259His Single submitter
Uncertain significance 104
- p.Ala136Thr Single submitter ⚠
- p.Ala553Thr Single submitter ⚠
- p.Ala731Thr Single submitter ⚠
- p.Arg32His Single submitter ⚠
- p.Arg369Cys Single submitter ⚠
- p.Arg369His Single submitter ⚠
- p.Arg430His Single submitter ⚠
- p.Arg559Pro Single submitter ⚠
- p.Arg565Ser Single submitter ⚠
- p.Arg631Cys Single submitter ⚠
- p.Arg631His Single submitter ⚠
- p.Arg673Cys Single submitter ⚠
- p.Arg774Gln Single submitter ⚠
- p.Arg800Trp Single submitter ⚠
- p.Arg912Cys Single submitter ⚠
- p.Asn137Lys Single submitter ⚠
- p.Asn513Lys Single submitter ⚠
- p.Asn534Ile Single submitter ⚠
- p.Asn534Ser Single submitter ⚠
- p.Asn63Ser Single submitter ⚠
- p.Asp252His Single submitter ⚠
- p.Asp374Glu Single submitter ⚠
- p.Asp55Glu Single submitter ⚠
- p.Gln35His Single submitter ⚠
- p.Gln455Arg Single submitter ⚠
- p.Gln826His Single submitter ⚠
- p.Glu187Lys Single submitter ⚠
- p.Glu297Ala Single submitter ⚠
- p.Glu468Gly Single submitter ⚠
- p.Glu468Val Single submitter ⚠
- p.Glu539Ala Single submitter ⚠
- p.Glu564Gly Single submitter ⚠
- p.Glu7Lys Single submitter ⚠
- p.Glu812Asp Single submitter ⚠
- p.Glu89Gly Single submitter ⚠
- p.Gly562Glu Single submitter ⚠
- p.Gly659Ala Single submitter ⚠
- p.Gly775Val Single submitter ⚠
- p.Gly790Val Single submitter ⚠
- p.Gly807Ala Single submitter ⚠
- p.His133Arg Single submitter ⚠
- p.His231Arg Single submitter ⚠
- p.His231Gln Single submitter ⚠
- p.Ile122Met Single submitter ⚠
- p.Ile134Leu Single submitter ⚠
- p.Ile151Phe Single submitter ⚠
- p.Ile331Thr Single submitter ⚠
- p.Ile442Thr Single submitter ⚠
- p.Ile505Thr Single submitter ⚠
- p.Ile599Val Single submitter ⚠
- p.Ile617Met Single submitter ⚠
- p.Ile666Thr Single submitter ⚠
- p.Ile74Met Single submitter ⚠
- p.Ile762Thr Single submitter ⚠
- p.Ile779Thr Single submitter ⚠
- p.Ile77Thr Single submitter ⚠
- p.Ile86Thr Single submitter ⚠
- p.Ile895Val Single submitter ⚠
- p.Leu121Val Single submitter ⚠
- p.Leu156Pro Single submitter ⚠
- p.Leu425Arg Single submitter ⚠
- p.Leu425Ile Single submitter ⚠
- p.Leu46Val Single submitter ⚠
- p.Leu556Met Single submitter ⚠
- p.Leu657Arg Single submitter ⚠
- p.Leu815Phe Single submitter ⚠
- p.Leu901Phe Single submitter ⚠
- p.Lys527Arg Single submitter ⚠
- p.Lys707Arg Single submitter ⚠
- p.Lys749Asn Single submitter ⚠
- p.Lys833Gln Single submitter ⚠
- p.Met262Ile Single submitter ⚠
- p.Met307Thr Single submitter ⚠
- p.Met711Thr Single submitter ⚠
- p.Met792Val Single submitter ⚠
- p.Phe481Ser Single submitter ⚠
- p.Pro418Leu Single submitter ⚠
- p.Pro640Ser Single submitter ⚠
- p.Pro739Ser Single submitter ⚠
- p.Pro770Ser Single submitter ⚠
- p.Ser427Thr Single submitter ⚠
- p.Ser606Thr Single submitter ⚠
- p.Ser611Cys Single submitter ⚠
- p.Ser777Asn Single submitter ⚠
- p.Ser838Cys Single submitter ⚠
- p.Thr647Asn Single submitter ⚠
- p.Thr732Ile Single submitter ⚠
- p.Thr733Ala Single submitter ⚠
- p.Thr750Ile Single submitter ⚠
- p.Thr893Ile Single submitter ⚠
- p.Trp656Cys Single submitter ⚠
- p.Trp699Cys Single submitter ⚠
- p.Tyr254Cys Single submitter ⚠
- p.Tyr259Cys Single submitter ⚠
- p.Tyr392Phe Single submitter ⚠
- p.Tyr446Cys Single submitter ⚠
- p.Tyr685His Single submitter ⚠
- p.Tyr75Cys Single submitter ⚠
- p.Val203Met Single submitter ⚠
- p.Val300Ile Single submitter ⚠
- p.Val470Met Single submitter ⚠
- p.Val486Ile Single submitter ⚠
- p.Val778Met Single submitter ⚠
- p.Val873Met Single submitter ⚠