GAPDH — 12 ClinVar variants
All ClinVar germline GAPDH variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 9 flagged for review →
1 Benign · 1 Likely benign · 10 Uncertain significance
Full GAPDH gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 9
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 5
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
Predictors split 4
The independent predictors disagree with each other — read with care.
All GAPDH variants
Benign 1
- c.-8C>G Multiple submitters
Likely benign 1
- p.Gly10= Single submitter
Uncertain significance 10
- p.Ala265Thr Single submitter
- p.Arg118Ser Single submitter ⚠
- p.Arg323Lys Single submitter ⚠
- p.Asn304Ser Single submitter ⚠
- p.Asp198Gly Single submitter ⚠
- p.His165Arg Single submitter ⚠
- p.Lys334Gln Single submitter ⚠
- p.Pro252Arg Single submitter ⚠
- p.Val119Phe Single submitter ⚠
- p.Val28Gly Single submitter ⚠