GAR1 — 24 ClinVar variants
All ClinVar germline GAR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
1 Likely benign · 23 Uncertain significance
Full GAR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 12
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GAR1 p.Arg189Gly Uncertain significance Single submitter
- GAR1 p.Asn99Ser Uncertain significance Single submitter
- GAR1 p.Asp147His Uncertain significance Single submitter
- GAR1 p.Asp63Gly Uncertain significance Single submitter
- GAR1 p.Gln64Glu Uncertain significance Single submitter
- GAR1 p.Gly163Asp Uncertain significance Single submitter
- GAR1 p.Ile110Met Uncertain significance Single submitter
- GAR1 p.Lys112Thr Uncertain significance Single submitter
- GAR1 p.Lys128Thr Uncertain significance Single submitter
- GAR1 p.Pro101Thr Uncertain significance Single submitter
- GAR1 p.Pro67Leu Uncertain significance Single submitter
- GAR1 p.Thr89Asn Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GAR1 p.Arg194Thr Uncertain significance Single submitter
- GAR1 p.Glu105Gln Uncertain significance Single submitter
- GAR1 p.Gly15Ser Uncertain significance Single submitter
- GAR1 p.Gly170Ala Uncertain significance Single submitter
- GAR1 p.Gly175Ser Uncertain significance Single submitter
- GAR1 p.Gly199Ala Uncertain significance Single submitter
- GAR1 p.Gly216Glu Uncertain significance Single submitter
- GAR1 p.Gly34Cys Uncertain significance Single submitter
- GAR1 p.Leu120Phe Uncertain significance Single submitter
- GAR1 p.Phe29Leu Uncertain significance Single submitter
All GAR1 variants
Likely benign 1
- p.Gly33Ser Single submitter
Uncertain significance 23
- p.Arg189Gly Single submitter ⚠
- p.Arg194Thr Single submitter ⚠
- p.Asn99Ser Single submitter ⚠
- p.Asp147His Single submitter ⚠
- p.Asp63Gly Single submitter ⚠
- p.Gln64Glu Single submitter ⚠
- p.Glu105Gln Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Gly163Asp Single submitter ⚠
- p.Gly170Ala Single submitter ⚠
- p.Gly175Ser Single submitter ⚠
- p.Gly199Ala Single submitter ⚠
- p.Gly216Glu Single submitter ⚠
- p.Gly34Cys Single submitter ⚠
- p.Gly7Asp Single submitter
- p.Ile110Met Single submitter ⚠
- p.Leu120Phe Single submitter ⚠
- p.Lys112Thr Single submitter ⚠
- p.Lys128Thr Single submitter ⚠
- p.Phe29Leu Single submitter ⚠
- p.Pro101Thr Single submitter ⚠
- p.Pro67Leu Single submitter ⚠
- p.Thr89Asn Single submitter ⚠