GATD3 — 6 ClinVar variants
All ClinVar germline GATD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 3 flagged for review →
2 Benign · 1 Likely benign · 3 Uncertain significance
Full GATD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 3
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 3
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
All GATD3 variants
Likely benign 1
- p.Ser22= Single submitter
Uncertain significance 3
- p.Ile213Met Single submitter ⚠
- p.Ile60Ser Single submitter ⚠
- p.Lys214Arg Single submitter ⚠