GCOM1 — 100 ClinVar variants
All ClinVar germline GCOM1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
5 Likely benign · 95 Uncertain significance
Full GCOM1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 76
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
GCOM1 p.Ala109Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ala168Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ala16Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ala288Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ala345Ser
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg117Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg130Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg159Cys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg159His
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg159Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg304Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg308Cys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg308His
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg32Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg350His
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg352Trp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg354Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg408Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg460Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg461His
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg523Trp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Asn187Asp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Asp180Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Asp542Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Asp548Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Asp57Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gln175Pro
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gln196Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gln512Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gln83Pro
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu250Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu265Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu270Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu420Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu457Asp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu62Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gly173Asp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gly533Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Gly70Ala
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.His323Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.His479Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile129Phe
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile192Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile278Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile290Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile306Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile306Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile374Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ile488Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Leu174Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Leu302Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Leu433Pro
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys113Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys113Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys128Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys378Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys418Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Met118Ile
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Met203Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Met225Val
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Met285Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Pro434Arg
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Pro437Ala
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Pro68Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser186Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser261Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser334Tyr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser39Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser407Gly
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser407Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser450Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Thr483Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Tyr90Cys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val179Met
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val35Ile
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val367Ile
Uncertain significance
Single submitter
Inborn genetic diseases
Predictors split 16
The independent predictors disagree with each other — read with care.
-
GCOM1 p.Arg108Thr
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg130Pro
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Arg32Trp
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu393Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Glu404Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys105Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys368Gln
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Lys384Glu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Met101Lys
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser229Pro
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Ser230Phe
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Thr34Asn
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Thr34Ile
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val72Leu
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val75Ala
Uncertain significance
Single submitter
Inborn genetic diseases
-
GCOM1 p.Val89Ala
Uncertain significance
Single submitter
Inborn genetic diseases
All GCOM1 variants
Likely benign 5
- p.Ala511= Single submitter Inborn genetic diseases
- p.Arg523Gln Single submitter Inborn genetic diseases
- p.Gly451Glu Single submitter Inborn genetic diseases
- p.Ile454Val Single submitter Inborn genetic diseases
- p.Lys508= Single submitter Inborn genetic diseases
Uncertain significance 95
- p.Ala109Thr Single submitter Inborn genetic diseases ⚠
- p.Ala168Val Single submitter Inborn genetic diseases ⚠
- p.Ala16Val Single submitter Inborn genetic diseases ⚠
- p.Ala288Thr Single submitter Inborn genetic diseases ⚠
- p.Ala345Ser Single submitter Inborn genetic diseases ⚠
- p.Arg108Thr Single submitter Inborn genetic diseases ⚠
- p.Arg117Gln Single submitter Inborn genetic diseases ⚠
- p.Arg130Leu Single submitter Inborn genetic diseases ⚠
- p.Arg130Pro Single submitter Inborn genetic diseases ⚠
- p.Arg159Cys Single submitter Inborn genetic diseases ⚠
- p.Arg159His Single submitter Inborn genetic diseases ⚠
- p.Arg159Leu Single submitter Inborn genetic diseases ⚠
- p.Arg304Lys Single submitter Inborn genetic diseases ⚠
- p.Arg308Cys Single submitter Inborn genetic diseases ⚠
- p.Arg308His Single submitter Inborn genetic diseases ⚠
- p.Arg32Gln Single submitter Inborn genetic diseases ⚠
- p.Arg32Trp Single submitter Inborn genetic diseases ⚠
- p.Arg350His Single submitter Inborn genetic diseases ⚠
- p.Arg352Trp Single submitter Inborn genetic diseases ⚠
- p.Arg354Lys Single submitter Inborn genetic diseases ⚠
- p.Arg408Met Single submitter Inborn genetic diseases ⚠
- p.Arg460Gln Single submitter Inborn genetic diseases ⚠
- p.Arg461His Single submitter Inborn genetic diseases ⚠
- p.Arg523Trp Single submitter Inborn genetic diseases ⚠
- p.Asn187Asp Single submitter Inborn genetic diseases ⚠
- p.Asp180Asn Single submitter Inborn genetic diseases ⚠
- p.Asp542Asn Single submitter Inborn genetic diseases ⚠
- p.Asp548Asn Single submitter Inborn genetic diseases ⚠
- p.Asp57Gly Single submitter Inborn genetic diseases ⚠
- p.Gln175Pro Single submitter Inborn genetic diseases ⚠
- p.Gln196Arg Single submitter Inborn genetic diseases ⚠
- p.Gln512Glu Single submitter Inborn genetic diseases ⚠
- p.Gln83Pro Single submitter Inborn genetic diseases ⚠
- p.Glu250Gln Single submitter Inborn genetic diseases ⚠
- p.Glu265Lys Single submitter Inborn genetic diseases ⚠
- p.Glu270Gly Single submitter Inborn genetic diseases ⚠
- p.Glu393Lys Single submitter Inborn genetic diseases ⚠
- p.Glu404Lys Single submitter Inborn genetic diseases ⚠
- p.Glu420Lys Single submitter Inborn genetic diseases ⚠
- p.Glu457Asp Single submitter Inborn genetic diseases ⚠
- p.Glu62Val Single submitter Inborn genetic diseases ⚠
- p.Gly173Asp Single submitter Inborn genetic diseases ⚠
- p.Gly533Glu Single submitter Inborn genetic diseases ⚠
- p.Gly70Ala Single submitter Inborn genetic diseases ⚠
- p.Gly70Asp Single submitter Inborn genetic diseases
- p.His260Arg Single submitter Inborn genetic diseases
- p.His323Gln Single submitter Inborn genetic diseases ⚠
- p.His479Gln Single submitter Inborn genetic diseases ⚠
- p.Ile129Phe Single submitter Inborn genetic diseases ⚠
- p.Ile192Met Single submitter Inborn genetic diseases ⚠
- p.Ile278Thr Single submitter Inborn genetic diseases ⚠
- p.Ile290Thr Single submitter Inborn genetic diseases ⚠
- p.Ile306Leu Single submitter Inborn genetic diseases ⚠
- p.Ile306Met Single submitter Inborn genetic diseases ⚠
- p.Ile374Leu Single submitter Inborn genetic diseases ⚠
- p.Ile488Thr Single submitter Inborn genetic diseases ⚠
- p.Leu174Met Single submitter Inborn genetic diseases ⚠
- p.Leu302Val Single submitter Inborn genetic diseases ⚠
- p.Leu433Pro Single submitter Inborn genetic diseases ⚠
- p.Lys105Asn Single submitter Inborn genetic diseases ⚠
- p.Lys113Gln Single submitter Inborn genetic diseases ⚠
- p.Lys113Glu Single submitter Inborn genetic diseases ⚠
- p.Lys128Glu Single submitter Inborn genetic diseases ⚠
- p.Lys368Gln Single submitter Inborn genetic diseases ⚠
- p.Lys378Glu Single submitter Inborn genetic diseases ⚠
- p.Lys384Glu Single submitter Inborn genetic diseases ⚠
- p.Lys418Asn Single submitter Inborn genetic diseases ⚠
- p.Met101Lys Single submitter Inborn genetic diseases ⚠
- p.Met118Ile Single submitter Inborn genetic diseases ⚠
- p.Met203Thr Single submitter Inborn genetic diseases ⚠
- p.Met225Val Single submitter Inborn genetic diseases ⚠
- p.Met285Leu Single submitter Inborn genetic diseases ⚠
- p.Pro434Arg Single submitter Inborn genetic diseases ⚠
- p.Pro437Ala Single submitter Inborn genetic diseases ⚠
- p.Pro68Leu Single submitter Inborn genetic diseases ⚠
- p.Ser186Gly Single submitter Inborn genetic diseases ⚠
- p.Ser229Pro Single submitter Inborn genetic diseases ⚠
- p.Ser230Phe Single submitter Inborn genetic diseases ⚠
- p.Ser261Gly Single submitter Inborn genetic diseases ⚠
- p.Ser334Tyr Single submitter Inborn genetic diseases ⚠
- p.Ser39Thr Single submitter Inborn genetic diseases ⚠
- p.Ser407Gly Single submitter Inborn genetic diseases ⚠
- p.Ser407Thr Single submitter Inborn genetic diseases ⚠
- p.Ser450Asn Single submitter Inborn genetic diseases ⚠
- p.Thr34Asn Single submitter Inborn genetic diseases ⚠
- p.Thr34Ile Single submitter Inborn genetic diseases ⚠
- p.Thr483Met Single submitter Inborn genetic diseases ⚠
- p.Tyr411Cys Single submitter Inborn genetic diseases
- p.Tyr90Cys Single submitter Inborn genetic diseases ⚠
- p.Val179Met Single submitter Inborn genetic diseases ⚠
- p.Val35Ile Single submitter Inborn genetic diseases ⚠
- p.Val367Ile Single submitter Inborn genetic diseases ⚠
- p.Val72Leu Single submitter Inborn genetic diseases ⚠
- p.Val75Ala Single submitter Inborn genetic diseases ⚠
- p.Val89Ala Single submitter Inborn genetic diseases ⚠