GDI2 — 43 ClinVar variants
All ClinVar germline GDI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
2 Benign · 1 Likely benign · 40 Uncertain significance
Full GDI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GDI2 p.Arg276His Uncertain significance Single submitter
- GDI2 p.Arg367Thr Uncertain significance Single submitter
- GDI2 p.Arg402Cys Uncertain significance Single submitter
- GDI2 p.Arg402His Uncertain significance Single submitter
- GDI2 p.Asn327Ser Uncertain significance Single submitter
- GDI2 p.Glu50Lys Uncertain significance Single submitter
- GDI2 p.Gly178Ser Uncertain significance Single submitter
- GDI2 p.Ile22Thr Uncertain significance Single submitter
- GDI2 p.Ile22Val Uncertain significance Single submitter
- GDI2 p.Ile244Leu Uncertain significance Single submitter
- GDI2 p.Ile255Val Uncertain significance Single submitter
- GDI2 p.Ile376Val Uncertain significance Single submitter
- GDI2 p.Ile8Val Uncertain significance Single submitter
- GDI2 p.Leu191Val Uncertain significance Single submitter
- GDI2 p.Leu91Gln Uncertain significance Single submitter
- GDI2 p.Lys29Asn Uncertain significance Single submitter
- GDI2 p.Lys57Thr Uncertain significance Single submitter
- GDI2 p.Met434Val Uncertain significance Single submitter
- GDI2 p.Met82Val Uncertain significance Single submitter
- GDI2 p.Phe158Ser Uncertain significance Single submitter
- GDI2 p.Pro155Ala Uncertain significance Single submitter
- GDI2 p.Pro163Leu Uncertain significance Single submitter
- GDI2 p.Pro59Thr Uncertain significance Single submitter
- GDI2 p.Thr166Asn Uncertain significance Single submitter
- GDI2 p.Tyr421Cys Uncertain significance Single submitter
- GDI2 p.Tyr421Phe Uncertain significance Single submitter
- GDI2 p.Val334Ile Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- GDI2 p.Arg169Gln Uncertain significance Single submitter
- GDI2 p.Asp71Glu Uncertain significance Single submitter
- GDI2 p.Cys414Tyr Uncertain significance Single submitter
- GDI2 p.Gln296His Uncertain significance Single submitter
- GDI2 p.Glu374Ala Uncertain significance Single submitter
- GDI2 p.Gly178Asp Uncertain significance Single submitter
- GDI2 p.Ile366Met Uncertain significance Single submitter
- GDI2 p.Phe431Leu Uncertain significance Single submitter
- GDI2 p.Pro201Leu Uncertain significance Single submitter
- GDI2 p.Thr205Ala Uncertain significance Single submitter
- GDI2 p.Tyr111Cys Uncertain significance Single submitter
- GDI2 p.Val287Ile Uncertain significance Single submitter
All GDI2 variants
Benign 2
- c.153+7G>A Multiple submitters
- p.Ile303Val Single submitter
Likely benign 1
- p.Tyr203Cys Single submitter
Uncertain significance 40
- p.Ala148Val Single submitter
- p.Arg169Gln Single submitter ⚠
- p.Arg276His Single submitter ⚠
- p.Arg367Thr Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Asn327Ser Single submitter ⚠
- p.Asp71Glu Single submitter ⚠
- p.Cys414Tyr Single submitter ⚠
- p.Gln296His Single submitter ⚠
- p.Glu374Ala Single submitter ⚠
- p.Glu50Lys Single submitter ⚠
- p.Gly178Asp Single submitter ⚠
- p.Gly178Ser Single submitter ⚠
- p.Ile22Thr Single submitter ⚠
- p.Ile22Val Single submitter ⚠
- p.Ile244Leu Single submitter ⚠
- p.Ile255Val Single submitter ⚠
- p.Ile366Met Single submitter ⚠
- p.Ile376Val Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu191Val Single submitter ⚠
- p.Leu91Gln Single submitter ⚠
- p.Lys29Asn Single submitter ⚠
- p.Lys57Thr Single submitter ⚠
- p.Met434Val Single submitter ⚠
- p.Met82Val Single submitter ⚠
- p.Phe158Ser Single submitter ⚠
- p.Phe431Leu Single submitter ⚠
- p.Pro155Ala Single submitter ⚠
- p.Pro163Leu Single submitter ⚠
- p.Pro201Leu Single submitter ⚠
- p.Pro59Thr Single submitter ⚠
- p.Thr166Asn Single submitter ⚠
- p.Thr205Ala Single submitter ⚠
- p.Tyr111Cys Single submitter ⚠
- p.Tyr421Cys Single submitter ⚠
- p.Tyr421Phe Single submitter ⚠
- p.Val287Ile Single submitter ⚠
- p.Val334Ile Single submitter ⚠