GDPGP1 — 68 ClinVar variants
All ClinVar germline GDPGP1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 64 flagged for review →
4 Likely benign · 64 Uncertain significance
Full GDPGP1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 64
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GDPGP1 p.Ala355Thr Uncertain significance Single submitter
- GDPGP1 p.Arg102Cys Uncertain significance Single submitter
- GDPGP1 p.Arg102Pro Uncertain significance Single submitter
- GDPGP1 p.Arg102Ser Uncertain significance Single submitter
- GDPGP1 p.Arg175Gly Uncertain significance Single submitter
- GDPGP1 p.Arg175Leu Uncertain significance Single submitter
- GDPGP1 p.Arg175Ser Uncertain significance Single submitter
- GDPGP1 p.Arg180Cys Uncertain significance Single submitter
- GDPGP1 p.Arg227Thr Uncertain significance Single submitter
- GDPGP1 p.Arg260Cys Uncertain significance Single submitter
- GDPGP1 p.Arg275Gln Uncertain significance Single submitter
- GDPGP1 p.Arg363Gln Uncertain significance Single submitter
- GDPGP1 p.Arg81Leu Uncertain significance Single submitter
- GDPGP1 p.Asn18Ser Uncertain significance Single submitter
- GDPGP1 p.Asn329Ser Uncertain significance Single submitter
- GDPGP1 p.Cys274Phe Uncertain significance Single submitter
- GDPGP1 p.Gln123Glu Uncertain significance Single submitter
- GDPGP1 p.Gln373Arg Uncertain significance Single submitter
- GDPGP1 p.Glu151Gln Uncertain significance Single submitter
- GDPGP1 p.Gly321Glu Uncertain significance Single submitter
- GDPGP1 p.Gly325Ser Uncertain significance Single submitter
- GDPGP1 p.Gly40Arg Uncertain significance Single submitter
- GDPGP1 p.Gly90Asp Uncertain significance Single submitter
- GDPGP1 p.His283Arg Uncertain significance Single submitter
- GDPGP1 p.Ile322Met Uncertain significance Single submitter
- GDPGP1 p.Leu13Val Uncertain significance Single submitter
- GDPGP1 p.Leu154Met Uncertain significance Single submitter
- GDPGP1 p.Leu358Phe Uncertain significance Single submitter
- GDPGP1 p.Leu3Arg Uncertain significance Single submitter
- GDPGP1 p.Lys317Met Uncertain significance Single submitter
- GDPGP1 p.Phe119Ser Uncertain significance Single submitter
- GDPGP1 p.Phe347Tyr Uncertain significance Single submitter
- GDPGP1 p.Pro121Ser Uncertain significance Single submitter
- GDPGP1 p.Pro171Arg Uncertain significance Single submitter
- GDPGP1 p.Pro240Ser Uncertain significance Single submitter
- GDPGP1 p.Pro296Ala Uncertain significance Single submitter
- GDPGP1 p.Pro296Leu Uncertain significance Single submitter
- GDPGP1 p.Ser213Leu Uncertain significance Single submitter
- GDPGP1 p.Ser271Arg Uncertain significance Single submitter
- GDPGP1 p.Thr259Ile Uncertain significance Single submitter
- GDPGP1 p.Thr259Pro Uncertain significance Single submitter
- GDPGP1 p.Val193Glu Uncertain significance Single submitter
- GDPGP1 p.Val230Met Uncertain significance Single submitter
- GDPGP1 p.Val372Ile Uncertain significance Single submitter
Predictors split 20
The independent predictors disagree with each other — read with care.
- GDPGP1 p.Ala233Gly Uncertain significance Single submitter
- GDPGP1 p.Arg137His Uncertain significance Single submitter
- GDPGP1 p.Arg140Gln Uncertain significance Single submitter
- GDPGP1 p.Arg140Trp Uncertain significance Single submitter
- GDPGP1 p.Arg175Pro Uncertain significance Single submitter
- GDPGP1 p.Arg202Cys Uncertain significance Single submitter
- GDPGP1 p.Arg275Trp Uncertain significance Single submitter
- GDPGP1 p.Arg293Gln Uncertain significance Single submitter
- GDPGP1 p.Arg293Trp Uncertain significance Single submitter
- GDPGP1 p.Arg77Cys Uncertain significance Single submitter
- GDPGP1 p.Gly308Arg Uncertain significance Single submitter
- GDPGP1 p.His198Pro Uncertain significance Single submitter
- GDPGP1 p.His245Pro Uncertain significance Single submitter
- GDPGP1 p.His287Tyr Uncertain significance Single submitter
- GDPGP1 p.Pro109Leu Uncertain significance Single submitter
- GDPGP1 p.Pro183Leu Uncertain significance Single submitter
- GDPGP1 p.Thr343Ile Uncertain significance Single submitter
- GDPGP1 p.Val115Met Uncertain significance Single submitter
- GDPGP1 p.Val156Met Likely benign Single submitter
- GDPGP1 p.Val95Met Uncertain significance Single submitter
All GDPGP1 variants
Likely benign 4
- p.Ala185Val Single submitter
- p.Arg81Gly Single submitter
- p.Gly22Asp Single submitter
- p.Val156Met Single submitter ⚠
Uncertain significance 64
- p.Ala233Gly Single submitter ⚠
- p.Ala355Thr Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg102Pro Single submitter ⚠
- p.Arg102Ser Single submitter ⚠
- p.Arg137His Single submitter ⚠
- p.Arg140Gln Single submitter ⚠
- p.Arg140Trp Single submitter ⚠
- p.Arg175Gly Single submitter ⚠
- p.Arg175Leu Single submitter ⚠
- p.Arg175Pro Single submitter ⚠
- p.Arg175Ser Single submitter ⚠
- p.Arg180Cys Single submitter ⚠
- p.Arg202Cys Single submitter ⚠
- p.Arg227Thr Single submitter ⚠
- p.Arg260Cys Single submitter ⚠
- p.Arg275Gln Single submitter ⚠
- p.Arg275Trp Single submitter ⚠
- p.Arg293Gln Single submitter ⚠
- p.Arg293Trp Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg77Cys Single submitter ⚠
- p.Arg81Leu Single submitter ⚠
- p.Asn18Ser Single submitter ⚠
- p.Asn329Ser Single submitter ⚠
- p.Cys274Phe Single submitter ⚠
- p.Gln123Glu Single submitter ⚠
- p.Gln373Arg Single submitter ⚠
- p.Gln97Glu Single submitter
- p.Glu151Gln Single submitter ⚠
- p.Gly308Arg Single submitter ⚠
- p.Gly321Glu Single submitter ⚠
- p.Gly325Ser Single submitter ⚠
- p.Gly40Arg Single submitter ⚠
- p.Gly90Asp Single submitter ⚠
- p.His198Pro Single submitter ⚠
- p.His245Pro Single submitter ⚠
- p.His283Arg Single submitter ⚠
- p.His287Tyr Single submitter ⚠
- p.Ile322Met Single submitter ⚠
- p.Leu13Val Single submitter ⚠
- p.Leu154Met Single submitter ⚠
- p.Leu358Phe Single submitter ⚠
- p.Leu3Arg Single submitter ⚠
- p.Lys317Met Single submitter ⚠
- p.Phe119Ser Single submitter ⚠
- p.Phe347Tyr Single submitter ⚠
- p.Pro109Leu Single submitter ⚠
- p.Pro121Ser Single submitter ⚠
- p.Pro171Arg Single submitter ⚠
- p.Pro183Leu Single submitter ⚠
- p.Pro240Ser Single submitter ⚠
- p.Pro296Ala Single submitter ⚠
- p.Pro296Leu Single submitter ⚠
- p.Ser213Leu Single submitter ⚠
- p.Ser271Arg Single submitter ⚠
- p.Thr259Ile Single submitter ⚠
- p.Thr259Pro Single submitter ⚠
- p.Thr343Ile Single submitter ⚠
- p.Val115Met Single submitter ⚠
- p.Val193Glu Single submitter ⚠
- p.Val230Met Single submitter ⚠
- p.Val372Ile Single submitter ⚠
- p.Val95Met Single submitter ⚠