GET3 — 31 ClinVar variants
All ClinVar germline GET3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 28 flagged for review →
1 Pathogenic · 1 Likely benign · 29 Uncertain significance
Full GET3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 28
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 24
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GET3 p.Ala112Gly Uncertain significance Single submitter
- GET3 p.Ala112Val Uncertain significance Single submitter
- GET3 p.Arg230His Uncertain significance Single submitter
- GET3 p.Arg65Cys Uncertain significance Single submitter
- GET3 p.Arg65His Uncertain significance Single submitter
- GET3 p.Asp284Asn Uncertain significance Single submitter
- GET3 p.Gln217Arg Uncertain significance Single submitter
- GET3 p.Glu113Gly Uncertain significance Single submitter
- GET3 p.Glu120Gln Uncertain significance Single submitter
- GET3 p.Glu286Lys Uncertain significance Single submitter
- GET3 p.Ile315Val Uncertain significance Single submitter
- GET3 p.Met158Val Uncertain significance Single submitter
- GET3 p.Met207Leu Uncertain significance Single submitter
- GET3 p.Pro285Ser Uncertain significance Single submitter
- GET3 p.Pro319Leu Uncertain significance Single submitter
- GET3 p.Pro344Ser Uncertain significance Single submitter
- GET3 p.Ser29Asn Uncertain significance Single submitter
- GET3 p.Ser346Thr Uncertain significance Single submitter
- GET3 p.Trp8Ser Uncertain significance Single submitter
- GET3 p.Val10Phe Uncertain significance Single submitter
- GET3 p.Val111Met Uncertain significance Single submitter
- GET3 p.Val228Ile Uncertain significance Single submitter
- GET3 p.Val94Ile Uncertain significance Single submitter
-
GET3 p.Pro75Arg
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 4
The independent predictors disagree with each other — read with care.
All GET3 variants
Pathogenic 1
- p.Val163Ala No assertion criteria cardiomyopathy, dilated, 2H
Likely benign 1
- p.Pro344= Single submitter
Uncertain significance 29
- p.Ala112Gly Single submitter ⚠
- p.Ala112Val Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg230His Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg65Cys Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Asp284Asn Single submitter ⚠
- p.Asp304His Single submitter ⚠
- p.Gln217Arg Single submitter ⚠
- p.Glu113Gly Single submitter ⚠
- p.Glu120Gln Single submitter ⚠
- p.Glu286Lys Single submitter ⚠
- p.His323Arg Single submitter ⚠
- p.Ile315Val Single submitter ⚠
- p.Met158Val Single submitter ⚠
- p.Met207Leu Single submitter ⚠
- p.Met213Thr Single submitter
- p.Pro285Ser Single submitter ⚠
- p.Pro319Leu Single submitter ⚠
- p.Pro344Ser Single submitter ⚠
- p.Ser29Asn Single submitter ⚠
- p.Ser346Thr Single submitter ⚠
- p.Trp8Ser Single submitter ⚠
- p.Val10Phe Single submitter ⚠
- p.Val111Met Single submitter ⚠
- p.Val228Ile Single submitter ⚠
- p.Val94Ile Single submitter ⚠
- p.Pro75Arg No assertion criteria prostate cancer ⚠