Sugi Variant

Sugi Variant/GFAP

GFAP — 552 ClinVar variants

All ClinVar germline GFAP variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 240 flagged for review →

47 Pathogenic · 2 Pathogenic/Likely pathogenic · 27 Likely pathogenic · 35 Conflicting · 37 Benign · 18 Benign/Likely benign · 123 Likely benign · 263 Uncertain significance

Full GFAP gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 240

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 8

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 23

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 151

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 151

Predictors split 58

The independent predictors disagree with each other — read with care.

All GFAP variants

Pathogenic 47

Pathogenic/Likely pathogenic 2

Likely pathogenic 27

Conflicting classifications of pathogenicity 35

Benign 37

Benign/Likely benign 18

Likely benign 123

Uncertain significance 263