GFRA2 — 66 ClinVar variants
All ClinVar germline GFRA2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 57 flagged for review →
2 Benign · 1 Likely benign · 63 Uncertain significance
Full GFRA2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 57
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GFRA2 p.Ala230Thr Uncertain significance Single submitter
- GFRA2 p.Ala372Thr Uncertain significance Single submitter
- GFRA2 p.Ala375Gly Uncertain significance Single submitter
- GFRA2 p.Arg18Leu Uncertain significance Single submitter
- GFRA2 p.Arg18Pro Uncertain significance Single submitter
- GFRA2 p.Arg194His Uncertain significance Single submitter
- GFRA2 p.Arg265Trp Uncertain significance Single submitter
- GFRA2 p.Arg267Trp Uncertain significance Single submitter
- GFRA2 p.Arg326His Uncertain significance Single submitter
- GFRA2 p.Arg377Gln Uncertain significance Single submitter
- GFRA2 p.Arg377Trp Uncertain significance Single submitter
- GFRA2 p.Asn186Lys Uncertain significance Single submitter
- GFRA2 p.Asn274Ser Uncertain significance Single submitter
- GFRA2 p.Asn414Ser Uncertain significance Single submitter
- GFRA2 p.Asn428Ser Uncertain significance Single submitter
- GFRA2 p.Asp270His Uncertain significance Single submitter
- GFRA2 p.Asp341Asn Uncertain significance Single submitter
- GFRA2 p.Cys347Phe Uncertain significance Single submitter
- GFRA2 p.Cys8Phe Uncertain significance Single submitter
- GFRA2 p.Glu15Asp Uncertain significance Single submitter
- GFRA2 p.Glu188Lys Uncertain significance Single submitter
- GFRA2 p.Glu344Lys Uncertain significance Single submitter
- GFRA2 p.Glu407Lys Uncertain significance Single submitter
- GFRA2 p.Gly329Arg Uncertain significance Single submitter
- GFRA2 p.Gly367Ala Uncertain significance Single submitter
- GFRA2 p.Gly432Arg Uncertain significance Single submitter
- GFRA2 p.His160Tyr Uncertain significance Single submitter
- GFRA2 p.His32Tyr Uncertain significance Single submitter
- GFRA2 p.Ile189Val Uncertain significance Single submitter
- GFRA2 p.Ile429Val Uncertain significance Single submitter
- GFRA2 p.Ile437Met Uncertain significance Single submitter
- GFRA2 p.Leu455Met Uncertain significance Single submitter
- GFRA2 p.Leu9Phe Uncertain significance Single submitter
- GFRA2 p.Lys435Asn Uncertain significance Single submitter
- GFRA2 p.Phe271Ser Uncertain significance Single submitter
- GFRA2 p.Pro314Ser Uncertain significance Single submitter
- GFRA2 p.Pro382Ser Uncertain significance Single submitter
- GFRA2 p.Pro382Thr Uncertain significance Single submitter
- GFRA2 p.Ser278Ala Uncertain significance Single submitter
- GFRA2 p.Ser441Leu Uncertain significance Single submitter
- GFRA2 p.Thr381Met Uncertain significance Single submitter
- GFRA2 p.Thr426Met Uncertain significance Single submitter
- GFRA2 p.Tyr243Phe Uncertain significance Single submitter
- GFRA2 p.Val211Met Uncertain significance Single submitter
- GFRA2 p.Val257Met Uncertain significance Single submitter
- GFRA2 p.Val454Met Uncertain significance Single submitter
- GFRA2 p.Val6Ile Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- GFRA2 p.Arg259Gln Uncertain significance Single submitter
- GFRA2 p.Arg259Trp Uncertain significance Single submitter
- GFRA2 p.Asn350Ser Uncertain significance Single submitter
- GFRA2 p.Gly299Ala Uncertain significance Single submitter
- GFRA2 p.Lys248Gln Uncertain significance Single submitter
- GFRA2 p.Met331Val Uncertain significance Single submitter
- GFRA2 p.Pro130Leu Uncertain significance Single submitter
- GFRA2 p.Pro249Ser Uncertain significance Single submitter
- GFRA2 p.Thr281Arg Uncertain significance Single submitter
- GFRA2 p.Thr281Met Uncertain significance Single submitter
All GFRA2 variants
Benign 2
- p.Pro443Ser Multiple submitters
- p.Ser449= Multiple submitters
Likely benign 1
- p.Asn434Lys Single submitter
Uncertain significance 63
- p.Ala228Val Single submitter
- p.Ala230Thr Single submitter ⚠
- p.Ala372Thr Single submitter ⚠
- p.Ala375Gly Single submitter ⚠
- p.Arg18Leu Single submitter ⚠
- p.Arg18Pro Single submitter ⚠
- p.Arg194His Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg259Gly Single submitter
- p.Arg259Trp Single submitter ⚠
- p.Arg265Trp Single submitter ⚠
- p.Arg267Trp Single submitter ⚠
- p.Arg276Pro Single submitter
- p.Arg326His Single submitter ⚠
- p.Arg377Gln Single submitter ⚠
- p.Arg377Trp Single submitter ⚠
- p.Asn186Lys Single submitter ⚠
- p.Asn274Ser Single submitter ⚠
- p.Asn308Ser Single submitter
- p.Asn350Ser Single submitter ⚠
- p.Asn414Ser Single submitter ⚠
- p.Asn428Ser Single submitter ⚠
- p.Asp270His Single submitter ⚠
- p.Asp341Asn Single submitter ⚠
- p.Cys347Phe Single submitter ⚠
- p.Cys8Phe Single submitter ⚠
- p.Glu15Asp Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Glu344Lys Single submitter ⚠
- p.Glu407Lys Single submitter ⚠
- p.Gly299Ala Single submitter ⚠
- p.Gly329Arg Single submitter ⚠
- p.Gly367Ala Single submitter ⚠
- p.Gly432Arg Single submitter ⚠
- p.His160Tyr Single submitter ⚠
- p.His32Tyr Single submitter ⚠
- p.Ile189Val Single submitter ⚠
- p.Ile429Val Single submitter ⚠
- p.Ile437Met Single submitter ⚠
- p.Leu455Met Single submitter ⚠
- p.Leu9Phe Single submitter ⚠
- p.Lys248Gln Single submitter ⚠
- p.Lys435Asn Single submitter ⚠
- p.Met331Val Single submitter ⚠
- p.Phe271Ser Single submitter ⚠
- p.Pro130Leu Single submitter ⚠
- p.Pro249Ser Single submitter ⚠
- p.Pro314Ser Single submitter ⚠
- p.Pro382Ser Single submitter ⚠
- p.Pro382Thr Single submitter ⚠
- p.Ser278Ala Single submitter ⚠
- p.Ser441Leu Single submitter ⚠
- p.Ser88Gly Single submitter
- p.Thr281Arg Single submitter ⚠
- p.Thr281Met Single submitter ⚠
- p.Thr381Met Single submitter ⚠
- p.Thr426Met Single submitter ⚠
- p.Tyr243Phe Single submitter ⚠
- p.Tyr279Cys Single submitter
- p.Val211Met Single submitter ⚠
- p.Val257Met Single submitter ⚠
- p.Val454Met Single submitter ⚠
- p.Val6Ile Single submitter ⚠