GFRA3 — 52 ClinVar variants
All ClinVar germline GFRA3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 4 Likely benign · 47 Uncertain significance
Full GFRA3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 38
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GFRA3 p.Ala212Glu Uncertain significance Single submitter
- GFRA3 p.Ala221Val Uncertain significance Single submitter
- GFRA3 p.Arg105Gln Uncertain significance Single submitter
- GFRA3 p.Arg124His Uncertain significance Single submitter
- GFRA3 p.Arg177Trp Uncertain significance Single submitter
- GFRA3 p.Arg179Cys Uncertain significance Single submitter
- GFRA3 p.Arg225Trp Uncertain significance Single submitter
- GFRA3 p.Arg253His Uncertain significance Single submitter
- GFRA3 p.Arg290Gln Uncertain significance Single submitter
- GFRA3 p.Arg319Gln Uncertain significance Single submitter
- GFRA3 p.Arg350His Uncertain significance Single submitter
- GFRA3 p.Arg378Lys Uncertain significance Single submitter
- GFRA3 p.Cys169Arg Uncertain significance Single submitter
- GFRA3 p.Gln380Arg Uncertain significance Single submitter
- GFRA3 p.Glu209Gln Uncertain significance Single submitter
- GFRA3 p.Gly188Arg Uncertain significance Single submitter
- GFRA3 p.Gly294Arg Uncertain significance Single submitter
- GFRA3 p.Gly333Ala Uncertain significance Single submitter
- GFRA3 p.His63Asn Uncertain significance Single submitter
- GFRA3 p.Leu171Phe Uncertain significance Single submitter
- GFRA3 p.Met102Ile Uncertain significance Single submitter
- GFRA3 p.Met147Val Uncertain significance Single submitter
- GFRA3 p.Met275Leu Uncertain significance Single submitter
- GFRA3 p.Pro12Thr Uncertain significance Single submitter
- GFRA3 p.Pro259Leu Uncertain significance Single submitter
- GFRA3 p.Pro25Leu Uncertain significance Single submitter
- GFRA3 p.Pro339Ser Uncertain significance Single submitter
- GFRA3 p.Pro7Leu Uncertain significance Single submitter
- GFRA3 p.Ser134Pro Uncertain significance Single submitter
- GFRA3 p.Ser286Tyr Uncertain significance Single submitter
- GFRA3 p.Ser315Thr Uncertain significance Single submitter
- GFRA3 p.Ser66Ala Uncertain significance Single submitter
- GFRA3 p.Thr139Ala Uncertain significance Single submitter
- GFRA3 p.Thr36Lys Uncertain significance Single submitter
- GFRA3 p.Val120Ile Uncertain significance Single submitter
- GFRA3 p.Val2Met Uncertain significance Single submitter
- GFRA3 p.Val383Met Uncertain significance Single submitter
-
GFRA3 p.Pro379Thr
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 7
The independent predictors disagree with each other — read with care.
- GFRA3 p.Arg179Leu Uncertain significance Single submitter
- GFRA3 p.Arg232His Uncertain significance Single submitter
- GFRA3 p.Arg264His Uncertain significance Single submitter
- GFRA3 p.Asn95Ile Uncertain significance Single submitter
- GFRA3 p.Lys180Asn Uncertain significance Single submitter
- GFRA3 p.Phe203Leu Uncertain significance Single submitter
- GFRA3 p.Val82Gly Uncertain significance Single submitter
All GFRA3 variants
Benign 1
- p.Cys316= Single submitter
Likely benign 4
- p.Arg262= Single submitter
- p.Asn238Ser Single submitter
- p.Gly333Glu Single submitter
- p.Thr56Ile Single submitter
Uncertain significance 47
- p.Ala212Glu Single submitter ⚠
- p.Ala221Val Single submitter ⚠
- p.Arg105Gln Single submitter ⚠
- p.Arg124His Single submitter ⚠
- p.Arg177Trp Single submitter ⚠
- p.Arg179Cys Single submitter ⚠
- p.Arg179Leu Single submitter ⚠
- p.Arg225Trp Single submitter ⚠
- p.Arg232His Single submitter ⚠
- p.Arg253His Single submitter ⚠
- p.Arg264His Single submitter ⚠
- p.Arg290Gln Single submitter ⚠
- p.Arg319Gln Single submitter ⚠
- p.Arg350His Single submitter ⚠
- p.Arg378Lys Single submitter ⚠
- p.Asn95Ile Single submitter ⚠
- p.Cys169Arg Single submitter ⚠
- p.Gln199Pro Single submitter
- p.Gln380Arg Single submitter ⚠
- p.Glu209Gln Single submitter ⚠
- p.Gly188Arg Single submitter ⚠
- p.Gly294Arg Single submitter ⚠
- p.Gly333Ala Single submitter ⚠
- p.His273Pro Single submitter
- p.His63Asn Single submitter ⚠
- p.Leu171Phe Single submitter ⚠
- p.Lys180Asn Single submitter ⚠
- p.Met102Ile Single submitter ⚠
- p.Met147Val Single submitter ⚠
- p.Met275Leu Single submitter ⚠
- p.Phe203Leu Single submitter ⚠
- p.Pro12Thr Single submitter ⚠
- p.Pro259Leu Single submitter ⚠
- p.Pro25Leu Single submitter ⚠
- p.Pro339Ser Single submitter ⚠
- p.Pro7Leu Single submitter ⚠
- p.Ser134Pro Single submitter ⚠
- p.Ser286Tyr Single submitter ⚠
- p.Ser315Thr Single submitter ⚠
- p.Ser66Ala Single submitter ⚠
- p.Thr139Ala Single submitter ⚠
- p.Thr36Lys Single submitter ⚠
- p.Val120Ile Single submitter ⚠
- p.Val2Met Single submitter ⚠
- p.Val383Met Single submitter ⚠
- p.Val82Gly Single submitter ⚠
- p.Pro379Thr No assertion criteria prostate cancer ⚠