GGCT — 26 ClinVar variants
All ClinVar germline GGCT variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 22 flagged for review →
1 Benign/Likely benign · 3 Likely benign · 22 Uncertain significance
Full GGCT gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 22
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 14
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- GGCT p.Asn90Tyr Uncertain significance Single submitter
- GGCT p.Asp167Asn Uncertain significance Single submitter
- GGCT p.Asp167Glu Uncertain significance Single submitter
- GGCT p.Gly183Ala Uncertain significance Single submitter
- GGCT p.Gly23Ser Uncertain significance Single submitter
- GGCT p.Gly81Val Uncertain significance Single submitter
- GGCT p.Ile163Lys Uncertain significance Single submitter
- GGCT p.Pro134Ser Uncertain significance Single submitter
- GGCT p.Pro165Thr Uncertain significance Single submitter
- GGCT p.Pro75Leu Uncertain significance Single submitter
- GGCT p.Ser56Cys Uncertain significance Single submitter
- GGCT p.Ser93Tyr Uncertain significance Single submitter
- GGCT p.Tyr139Cys Uncertain significance Single submitter
- GGCT p.Tyr156Cys Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- GGCT p.Asn35Ser Uncertain significance Single submitter
- GGCT p.Glu131Gly Uncertain significance Single submitter
- GGCT p.His32Pro Uncertain significance Single submitter
- GGCT p.Ser4Trp Uncertain significance Single submitter
- GGCT p.Ser61Asn Uncertain significance Single submitter
- GGCT p.Val43Gly Uncertain significance Single submitter
- GGCT p.Val43Met Uncertain significance Single submitter
- GGCT p.Val82Ile Uncertain significance Single submitter
All GGCT variants
Benign/Likely benign 1
- p.Pro153= Multiple submitters
Likely benign 3
- p.Asn3= Single submitter
- p.Glu96Lys Single submitter
- p.Ile142= Single submitter
Uncertain significance 22
- p.Asn35Ser Single submitter ⚠
- p.Asn90Tyr Single submitter ⚠
- p.Asp167Asn Single submitter ⚠
- p.Asp167Glu Single submitter ⚠
- p.Glu131Gly Single submitter ⚠
- p.Gly183Ala Single submitter ⚠
- p.Gly23Ser Single submitter ⚠
- p.Gly81Val Single submitter ⚠
- p.His32Pro Single submitter ⚠
- p.Ile163Lys Single submitter ⚠
- p.Pro134Ser Single submitter ⚠
- p.Pro165Thr Single submitter ⚠
- p.Pro75Leu Single submitter ⚠
- p.Ser4Trp Single submitter ⚠
- p.Ser56Cys Single submitter ⚠
- p.Ser61Asn Single submitter ⚠
- p.Ser93Tyr Single submitter ⚠
- p.Tyr139Cys Single submitter ⚠
- p.Tyr156Cys Single submitter ⚠
- p.Val43Gly Single submitter ⚠
- p.Val43Met Single submitter ⚠
- p.Val82Ile Single submitter ⚠